• 介绍：

  根皮素  Phloretin (NSC 407292; RJC 02792) 是一种从苹果中提取的黄酮类化合物，具有抗炎活性。Phloridzin 是一种特异性、竞争性和口服活性的钠/葡萄糖协同转运蛋白 (sodium/glucose cotransporters) 抑制剂，在肠道 (SGLT1) 和肾脏 (SGLT2)。Phloretin 抑制 Yeast-made GLUT1 以及人类红细胞 GLUT1 的 IC50 值分别为 49 μM 和 61 μM。Phloretin 具有潜力用于类风湿性关节炎 (RA) 和过敏性气道炎症的相关研究。

• 熔点： 260-262°C

• 沸点： 534.4 °C at 760 mmHg

• 外观： 淡红色粉末状

• 溶解性： DMSO  :  50  mg/mL  (182.30  mM;  Need  ultrasonic)
  
  H2O  :  0.1  mg/mL  (0.36  mM;  Need  ultrasonic)

• 敏感性： 对热和光敏感

• 储存条件： -20℃

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

• 38. [IF=5.6] Yan Duan et al."UPLC-Q–TOF–MS, network analysis, and molecular docking to investigate the effect and active ingredients of tea-seed oil against bacterial pathogens."Frontiers in Pharmacology.10.3389/fphar.2023.1225515

• 37. [IF=6.1] Jie Li et al."Phloretin alleviates palmitic acid-induced oxidative stress in HUVEC cells by suppressing the expression of LncBAG6-AS."Food & Function.10.1039/D3FO03523A

• 36. [IF=7.9] Qingqing Ruan et al."Phloretin-induced STAT3 inhibition suppresses pancreatic cancer growth and progression via enhancing Nrf2 activity."PHYTOMEDICINE.2023 Sep;118:154990

• 35. [IF=1.7] Zhouyi Zhang et al."Revealing the differences in phenolics in different parts of Taraxacum mongolicum using UPLC-MS/MS."Phytochemistry Letters.2023 Aug;56:13

• 34. [IF=6] Xiaoyue Yang et al."Effect of plant polyphenols with different m-hydroxy and o-hydroxy groups on the inhibition of heterocyclic amines formation in roasted meat."FOOD CONTROL.2023 Jun;:109960

• 33. [IF=1.967] ke Zunli et al."Physicochemical characteristics, polyphenols and antioxidant activities of Dimocarpus longan grown in different geographical locations."ANALYTICAL SCIENCES.2023 Apr;:1-8

• 32. [IF=4.036] Zhongyu Lu et al."Cocrystal of phloretin with isoniazid: preparation, characterization, and evaluation."RSC Advances.2023 Apr;13(16):10914-10922

• 31. [4.927] Wengang Zhang et al."Polyphenol Profile and In Vitro Antioxidant and Enzyme Inhibitory Activities of Different Solvent Extracts of Highland Barley Bran."MOLECULES.2023 Jan;28(4):1665

• 30. [6.317] Qingqing Ma et al."Thinned young apple polyphenol may prevent neuronal apoptosis by up-regulating 5-hydroxymethylcytosine in cerebral cortex of high-fat diet-induced diabetic mice."Food & Function.2023 Feb;:

• 29. [5.581] Li, Yuanyuan et al."Simultaneous Extraction of Flavonoid Glycosides and Flavonoid Aglycones from Discarded Apple Branches by Enzyme-assisted Micelle-mediated Extraction with Cloud Point Enrichment Method."Food and Bioprocess Technology.2022 Dec;:1-13

• 28. [7.31] Dan Song et al."Protective Effect of Phloretin against Hydrogen Peroxide-Induced Oxidative Damage by Enhancing Autophagic Flux in DF-1 Cells."Oxidative Medicine and Cellular Longevity.2022 Dec 30;2022:8359118

• 27. [IF=5.561] Xueshan Yang et al."Effect of Deacidification Treatment on the Flavor Quality of Zaosu Pear–Kiwifruit Wine."Foods.2022 Jan;11(14):2007

• 26. [IF=6.208] Yan Chen et al."Characterization of the Key Bibenzyl Synthase in Dendrobium sinense."INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.2022 Jan;23(12):6780

• 25. [IF=6.576] Junkun Pan et al."Inhibition of Dipeptidyl Peptidase-4 by Flavonoids: Structure–Activity Relationship, Kinetics and Interaction Mechanism."Frontiers in Nutrition. 2022; 9: 892426

• 24. [IF=7.514] Jie Meng et al."Conduction of a chemical structure-guided metabolic phenotype analysis method targeting phenylpropane pathway via LC-MS: Ginkgo biloba and soybean as examples."FOOD CHEMISTRY. 2022 Oct;390:133155

• 23. [IF=2.391] Tan Si et al."Effects of three drying methods on polyphenol composition and antioxidant activities of Litchi chinensis Sonn.."Food Sci Biotechnol. 2020 Mar;29(3):351-358

• 22. [IF=4.171] Lin Han et al."Activation of AMPK/Sirt3 pathway by phloretin reduces mitochondrial ROS in vascular endothelium by increasing the activity of MnSOD via deacetylation."Food Funct. 2020 Apr;11(4):3073-3083

• 21. [IF=4.24] Mengzhen Han et al."Effect of mixed Lactobacillus on the physicochemical properties of cloudy apple juice with the addition of polyphenols-concentrated solution."Food Biosci. 2021 Jun;41:101049

• 20. [IF=4.952] Si Tan et al."The effects of drying methods on chemical profiles and antioxidant activities of two cultivars of Psidium guajava fruits."Lwt Food Sci Technol. 2020 Jan;118:108723

• 19. [IF=5.537] Tiantian Tang et al."A difference of enzymatic browning unrelated to PPO from physiology, targeted metabolomics and gene expression analysis in Fuji apples."Postharvest Biol Tec. 2020 Dec;170:111323

• 18. [IF=5.64] Zhang Yuxiang et al."Structure-Dependent Inhibition of Stenotrophomonas maltophilia by Polyphenol and Its Impact on Cell Membrane."Front Microbiol. 2019 Nov;0:2646

• 17. [IF=5.81] Mu Jianfei et al."Determination of Polyphenols in Ilex kudingcha and Insect Tea (Leaves Altered by Animals) by Ultra-high-performance Liquid Chromatography-Triple Quadrupole Mass Spectrometry (UHPLC-QqQ-MS) and Comparison of Their Anti-Aging Effects."Fro

• 16. [IF=7.514] Hongcai Li et al."Study on the nutritional characteristics and antioxidant activity of dealcoholized sequentially fermented apple juice with Saccharomyces cerevisiae and Lactobacillus plantarum fermentation."Food Chem. 2021 Nov;363:130351

• 15. [IF=7.514] Jing Zhao et al."A sensitive and practical ELISA for analyzing naringenin in pummelo and herb samples."Food Chem. 2021 Nov;362:130223

• 14. [IF=7.514] Pei Pu et al."Six flavonoids inhibit the antigenicity of β-lactoglobulin by noncovalent interactions: A spectroscopic and molecular docking study."Food Chem. 2021 Mar;339:128106

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• 12. [IF=3.571] Qing Yang et al."Activation of Nrf2 by Phloretin Attenuates Palmitic Acid-Induced Endothelial Cell Oxidative Stress via AMPK-Dependent Signaling."J Agr Food Chem. 2019;67(1):120–131

• 11. [IF=4.729] Kun Zhou et al."Genome-wide identification of glycosyltransferases converting phloretin to phloridzin in Malus species."Plant Sci. 2017 Dec;265:131

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• 8. [IF=6.953] Lin Han et al."Inhibitory effect of phloretin on α-glucosidase: Kinetics, interaction mechanism and molecular docking."Int J Biol Macromol. 2017 Feb;95:520

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• 6. Pei Pu, Xin Zheng, Linna Jiao, Lang Chen, Han Yang, Yonghong Zhang, Guizhao Liang, Six flavonoids inhibit the antigenicity of β-lactoglobulin by noncovalent interactions: A spectroscopic and molecular docking study, Food Chemistry, Volume 339, 2021, 128106

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• 2. 冉峥, 郭艳丽, 王丽凤,等. 黄诺马苷在MDCK单层细胞模型上的转运机制分析[J]. 中国实验方剂学杂志, 2019(15):155-160.

• 1. 张国文, 宋欣, 曾霓. 根皮素对酪氨酸酶活性与构象的影响[J]. 南昌大学学报:理科版, 2018(6):557-562.

输入产品批号：

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *