• 介绍：

   Tripterin (Celastrol) 是一种蛋白酶体抑制剂，有效且优先抑制20S 蛋白酶体的胰凝乳蛋白酶样活性，IC50 为2.5 μM。

• 熔点： 185-200°C

• 沸点： 645.7 °C at 760 mmHg

• 外观： 红色粉末

• 溶解性： DMSO  :  33.33  mg/mL  (73.97  mM;  Need  ultrasonic)
  
  H2O  :  <  0.1  mg/mL  (ultrasonic;warming;heat  to  60°C)  (insoluble)

• 储存条件： -20℃

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

• 23. [IF=10.2] Piao Luo et al."Mechanistic engineering of celastrol liposomes induces ferroptosis and apoptosis by directly targeting VDAC2 in hepatocellular carcinoma."Asian Journal of Pharmaceutical Sciences.2023 Nov;18:100874

• 22. [IF=3.3] Wan Lei et al."A novel pharmaceutical preparation of Tripterygium wilfordii Hook. f. regulates macrophage polarization to alleviate inflammation in rheumatoid arthritis."JOURNAL OF PHARMACY AND PHARMACOLOGY.10.1093/jpp/rgad078

• 21. [IF=3] Ling Ye et al."Celastrol attenuates HFD-induced obesity and improves metabolic function independent of adiponectin signaling."ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY.

• 20. [IF=11.092] Hongwen Liu et al."Copper Increases the Sensitivity of Cholangiocarcinoma Cells to Tripterine by Inhibiting TMX2-Mediated Unfolded Protein Reaction Activation."Advanced Healthcare Materials.2023 Apr;:2300913

• 19. [IF=6.533] Liying Guo et al."Celastrol attenuates 6-hydroxydopamine-induced neurotoxicity by regulating the miR-146a/PI3K/Akt/mTOR signaling pathways in differentiated rat pheochromocytoma cells."JOURNAL OF AFFECTIVE DISORDERS.2022 Nov;316:233

• 18. [IF=6.656] Si-wei Wang et al."Celastrol inhibits TXNIP expression to protect pancreatic β cells in diabetic mice."PHYTOMEDICINE.2022 Sep;104:154316

• 17. [IF=3.981] Qian Kang et al."Application of quality by design approach to formulate and optimize tripterine loaded in nanostructured lipid carriers for transdermal delivery."J Drug Deliv Sci Tec. 2019 Aug;52:1032

• 16. [IF=6.4] Jinran Li et al."Celastrol Self-Stabilized Nanoparticles for Effective Treatment of Melanoma."Int J Nanomed. 2020; 15: 1205–1214

• 15. [IF=6.953] Yun Qian et al."Nanoparticles based on polymers modified with pH-sensitive molecular switch and low molecular weight heparin carrying Celastrol and ferrocene for breast cancer treatment."Int J Biol Macromol. 2021 Jul;183:2215

• 14. Sun, J, Wang, H-J, Yu, J, Li, T, Han, Y. Protective effect of celastrol on type 2 diabetes mellitus with nonalcoholic fatty liver disease in mice. Food Sci Nutr. 2020; 8: 6207– 6216. https://doi.org/10.1002/fsn3.1917

• 13. Kang, Qian, et al. "Application of quality by design approach to formulate and optimize tripterine loaded in nanostructured lipid carriers for transdermal delivery." Journal of Drug Delivery Science and Technology 52 (2019): 1032-1041.https://doi.org/10.10

• 12. 胡世尚,周圆圆,吴子豪,朱敏,郗雪艳,杜伯雨,喻青青.重楼皂苷Ⅶ对胰腺癌细胞的作用研究[J].湖北医药学院学报,2020,39(06):544-550+528

• 11. 徐佳, 伍春莲, 黄杰. 雷公藤红素通过影响Akt信号通路和整合素表达抑制肺癌细胞的转移[J]. 中国中药杂志, 2015, 40(006):1129-1133.

• 10. 徐佳, 伍春莲. 雷公藤红素诱导非小细胞肺癌H1299细胞凋亡及其机制研究[J]. 中药材, 2015, 38(09):1925-1928.

• 9. 柯波, 万才水, 李安娜,等. 雷公藤红素诱导多发性骨髓瘤H929细胞凋亡[J]. 中国病理生理杂志, 2020(3):487-494.

• 8. 胡绍英, 张振海, 蒋艳荣, et al. 雷公藤红素胶体二氧化硅缓释固体分散体研究[J]. 中草药, 2013(6):692-695.

• 7. 夏海建, 张振海, 贾晓斌. 雷公藤红素缓释滴丸的研究[J]. 中草药, 2013, 44(7):834-838.

• 6. 夏海建, 2], 张振海,等. 雷公藤红素环糊精与油自组装小珠载药系统的制备及其体外评价[J]. 中草药, 2013, 44(019):2672-2676.

• 5. 吴章, 吕望, 陈新国,等. 雷公藤红素对高糖诱导的H9C2细胞损伤的保护作用[J]. 温州医科大学学报, 2020(1):24-29.

• 4. 徐佳, 伍春莲, 彭聪,等. 雷公藤红素对人肺癌细胞增殖与凋亡的影响[J]. 西华师范大学学报(自然科学版), 2014(1):51-56.

• 3. 王黎,秦桂芳,柯鸿,魏广民.雷公藤红素对人急性早幼粒细胞白血病SCID小鼠移植瘤模型凝血功能的影响[J].中国中医急症,2019,28(02):232-235.

• 2. 陈小云, 张振海, 胡绍英,等. 基于硬脂酸改性纳米碳酸钙的雷公藤红素缓释固体分散体的研究[J]. 中国药学杂志, 2013, 48(16):1380-1384.

• 1. 胡绍英, 张振海, 蒋艳荣,等. 基于HPMC-硬脂酸的雷公藤红素缓释固体分散体的研究[J]. 中国中药杂志, 2012, 37(020):3052-3055.

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *