• 熔点： 226-227°C

• 沸点： 601.7 °C at 760 mmHg

• 比旋光度： D25 -154°

• 外观： 白色或微黄的结晶

• 溶解性： 难溶于水，溶于甲醇、乙酸乙酯、氯仿等。

• 储存条件： 2-8℃

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

• 56. [IF=2.9] Hanping Liang et al."Triptolide inhibits esophageal squamous cell carcinoma progression by regulating the circNOX4/miR-153-3p/SATB1 signaling pathway."Thoracic Cancer.2024 Jan;:

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• 54. [IF=5.1] Wang Qian et al."HSP90 Exacerbates Bone Destruction in Rheumatoid Arthritis by Activating TRAF6/NFATc1 Signaling."INFLAMMATION.2023 Oct;:1-13

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• 52. [IF=7.9] Zhiyan Qin et al."Mitigation of triptolide-induced testicular Sertoli cell damage by melatonin via regulating the crosstalk between SIRT1 and NRF2."PHYTOMEDICINE.2023 Sep;118:154945

• 51. [3.222] Chenlei Lv et al."Triptolide protects against podocyte injury in diabetic nephropathy by activating the Nrf2/HO-1 pathway and inhibiting the NLRP3 inflammasome pathway."RENAL FAILURE.2023;45(1):Article: 2165103

• 50. [9.417] Yunan Zhao et al."Engineering adipocytes for targeting delivery of triptolide derivative and Ce6 for malignant melanoma cytotoxic-PDT synergistic strategy."MATERIALS & DESIGN.2023 Apr;228:111860

• 49. [2.626] Ma, Rui-jiao et al."Kunxian Capsule Extract Inhibits Angiogenesis in Zebrafish Embryos via PI3K/AKT-MAPK-VEGF Pathway."Chinese Journal of Integrative Medicine.2022 Dec;:1-9

• 48. [IF=3.685] Guoyao Tan et al."MitoQ alleviates triptolide-induced cardiotoxicity via activation of p62/Nrf2 axis in H9c2 cells."TOXICOLOGY IN VITRO.2023 Feb;86:105487

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• 46. [IF=2.984] Linluo Zhang et al."Protection of catalpol against triptolide-induced hepatotoxicity by inhibiting excessive autophagy via the PERK-ATF4-CHOP pathway."Peerj. 2022 Jan;10:e12759

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• 44. [IF=3.411] Zhou Yuyan et al."Arctiin Antagonizes Triptolide-Induced Hepatotoxicity via Activation of Nrf2 Pathway."Biomed Res Int. 2020;2020:2508952

• 43. [IF=4.617] Li Zhe et al."γ-Cyclodextrin metal–organic framework as a carrier to deliver triptolide for the treatment of hepatocellular carcinoma."Drug Delivery and Translational Research. 2021 Apr 15

• 42. [IF=5.914] Bo Ma et al."Luteolin Ameliorates Testis Injury and Blood–Testis Barrier Disruption through the Nrf2 Signaling Pathway and by Upregulating Cx43."Mol Nutr Food Res. 2019 May;63(10):1800843

• 41. [IF=6.419] Yanwen Zheng et al."Membrane protein-chimeric liposome-mediated delivery of triptolide for targeted hepatocellular carcinoma therapy."Drug Deliv. 2021;28(1):2033-2043

• 40. [IF=6.684] Yi-Sheng Song et al."Validation, Optimization, and Application of the Zebrafish Developmental Toxicity Assay for Pharmaceuticals Under the ICH S5(R3) Guideline."Front Cell Dev Biol. 2021; 9: 721130

• 39. [IF=9.229] Liangdi Jiang et al."Engineering Exosomes Endowed with Targeted Delivery of Triptolide for Malignant Melanoma Therapy."Acs Appl Mater Inter. 2021;13(36):42411–42428

• 38. [IF=2.303] Ingrid Elisia et al."Comparison of RAW264.7, human whole blood and PBMC assays to screen for immunomodulators."J Immunol Methods. 2018 Jan;452:26

• 37. [IF=3.347] Jiamin Kong et al."Triptolide induces mitochondria-mediated apoptosis of Burkitt's lymphoma cell via deacetylation of GSK-3β by increased SIRT3 expression."Toxicol Appl Pharm. 2018 Mar;342:1

• 36. [IF=3.585] Jie Zhang et al."MitoQ ameliorates testis injury from oxidative attack by repairing mitochondria and promoting the Keap1-Nrf2 pathway."Toxicol Appl Pharm. 2019 May;370:78

• 35. [IF=5.875] Yongwei Gu et al."Transdermal drug delivery of triptolide-loaded nanostructured lipid carriers: Preparation, pharmacokinetic, and evaluation for rheumatoid arthritis."Int J Pharmaceut. 2019 Jan;554:235

• 34. [IF=6.4] Li Zhang et al."Fabrication of a triptolide-loaded and poly-γ-glutamic acid-based amphiphilic nanoparticle for the treatment of rheumatoid arthritis."Int J Nanomed. 2018; 13: 2051–2064

• 33. [IF=10.435] Yang Meng et al."Development of triptolide-nanoemulsion gels for percutaneous administration: physicochemical, transport, pharmacokinetic and pharmacodynamic characteristics."J Nanobiotechnol. 2017 Dec;15(1):1-15

• 32. [IF=10.435] Gu Yongwei et al."Lipid nanoparticles loading triptolide for transdermal delivery: mechanisms of penetration enhancement and transport properties."J Nanobiotechnol. 2018 Dec;16(1):1-14

• 31. Elisia, Ingrid, et al. "Comparison of RAW264. 7, human whole blood and PBMC assays to screen for immunomodulators." Journal of immunological methods 452 (2018): 26-31.https://doi.org/10.1016/j.jim.2017.10.004

• 30. Shan, Qian-Qian, et al. "Cubic and hexagonal liquid crystals as drug carriers for the transdermal delivery of triptolide." Drug delivery 26.1 (2019): 490-498.https://doi.org/10.1080/10717544.2019.1602796

• 29. Yang, Meng, et al. "Development of triptolide-nanoemulsion gels for percutaneous administration: physicochemical, transport, pharmacokinetic and pharmacodynamic characteristics." Journal of nanobiotechnology 15.1 (2017): 1-15.https://doi.org/10.1186/s12951

• 28. Zhang, Jie, et al. "MitoQ ameliorates testis injury from oxidative attack by repairing mitochondria and promoting the Keap1-Nrf2 pathway." Toxicology and applied pharmacology 370 (2019): 78-92.https://doi.org/10.1016/j.taap.2019.03.001

• 27. 汪五清,贺燕妮,曾义斌,张彤,朱瑞政,左付国.雷公藤甲素固体脂质纳米粒的制备及其抗慢性皮炎湿疹的作用研究[J].上海医药,2021,42(01):14-18+31.

• 26. 周玉燕,陆萧雅,夏丽,姚伟强,秦国正,王国栋.牛蒡子苷通过抑制炎症通路降低雷公藤甲素所致肾毒性[J].南方医科大学学报,2020,40(10):1399-1405.

• 25. 曾晶,朱龙.响应曲面法优化雷公藤甲素的微波萃取工艺[J].生物化工,2020,6(04):1-4.

• 24. 陈琪,周静威,孙满强,李世超,周欢欢,李岩.地黄水提物减轻雷公藤甲素所致肝脏氧化应激损伤的实验研究[J].世界中西医结合杂志,2020,15(12):2241-2245+2251.

• 23. 周玉燕, 孙玉, 李萍,等. 莫诺苷通过抗氧化应激保护雷公藤甲素所致肝细胞凋亡[J]. 南方医科大学学报, 2018, 038(008):949-955.

• 22. 臧勇, 田园, 李卫东. 雷公藤甲素通过调节TGF-β1信号通路和Hippo信号通路影响肾小管上皮细胞的上皮-间充质转化[J]. 天津医科大学学报, 2019, 025(003):205-209,224.

• 21. 方妍妍,万磊,董文哲,文建庭,刘健.雷公藤甲素通过调控VEGFA,SDF-1,CXCR4通路改善强直性脊柱炎患者血小板活化的机制[J].中国中药杂志,2019,44(16):3520-3525.

• 20. 王爱利, 王蓓蓓, 罗光伟. 雷公藤甲素通过IL-10/Th17细胞调节哮喘小鼠气道炎症[J]. 内科急危重症杂志, 2019, 25(4).

• 19. 万磊,刘健,黄传兵,张晓军,王亚黎,章平衡,孙玥,刘磊.雷公藤甲素调节佐剂关节炎大鼠滑膜、脾脏、胸腺组织细胞自噬的实验研究[J].四川大学学报(医学版),2017,48(04):520-525.

• 18. 罗国平, 孟会宁, 闫梦茹,等. 雷公藤甲素热敏醇质体的制备工艺[J]. 化工科技, 2020, 028(002):46-51.

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• 16. 李文,杨莉莉,王东明,何翔,丁佩军,贺旭锋,边风华,赵晓娴,陈文君,张慧敏.雷公藤甲素对黑色素瘤A375细胞EMT通路及侵袭能力的作用研究[J].上海中医药杂志,2020,54(S1):153-155.

• 15. 李文化, 白雪梅, 吴耀东,等. 雷公藤甲素对早期2型糖尿病大鼠肾脏的保护作用[J]. 河北北方学院学报(自然科学版), 2015, 000(005):77-80.

• 14. 万磊, 刘健, 黄传兵,等. 雷公藤甲素对关节炎大鼠心功能的影响及其作用机制探讨[J]. 四川大学学报(医学版), 2020, v.51(02):82-87.

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• 10. 范兆峰, 归小龙, 黄赛杰. 用LC/MS法测定雷公藤甲素纳米乳中雷公藤甲素的含量[J]. 药学服务与研究, 2018, v.18(06):50-53.

• 9. 汪文强, 邓奇, 肖安菊. 湖北黄石野生驯化扦插雷公藤芽、叶中雷公藤甲素的含量分析[J]. 广州中医药大学学报, 2016, 33(006):868-871.

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• 7. 周玉燕, 王明艳, 潘学娟,等. 斑蝥酸钠协同雷公藤甲素诱导肝癌细胞株7721凋亡[J]. 中南大学学报(医学版), 2016, 41(9):911-917.

• 6. 黄国东,淮国丽,杨洪吉,王轶,向少伟,覃振林,庞健丽,罗欢,张亚萍,刘振威,许健,吕建珍.复方仙草颗粒对人肾足细胞保护作用的研究[J].北京中医药,2017,36(05):410-415+481.

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• 2. 曾晶 朱龙.响应曲面法优化雷公藤甲素的微波萃取工艺[J].生物化工 2020 6(04):1-4.

• 1. 赵东晓 陈弘磊 孟冠敏 等. 低浓度雷公藤甲素联合顺铂对肝癌细胞HepG2活性的影响[J]. 浙江中西医结合杂志 2017年27卷5期 366-369页 2017.

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *