• 介绍：

  Streptozocin 是一种抗生素，可使 DNA 甲基化 (DNA-methylating) 。Streptozocin 引起肝脏，肾脏及胰腺 DNA 甲基化，但脑 DNA 中没有甲基化。

  
  

   

• 熔点： 115℃

• 外观： 淡黄色结晶粉末

• 溶解性： H2O  :  113.3  mg/mL  (427.19  mM;  Need  ultrasonic  and  warming)
  
  DMSO  :  83.33  mg/mL  (314.19  mM;  Need  ultrasonic)，
  
  故需现用现配

• 敏感性： 易吸潮

• 储存条件： -20℃

• 用途： 本品仅供科研，不得用于其它用途。

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

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• 78. [IF=1.6] Chen Xiaoyu et al."Faecal Untargeted Metabolomics Analysis Elucidates the Antihyperglycaemic Effect of Surfactin in High-Fat Diet/Streptozotocin-Induced Type 2 Diabetic Mice."Revista Brasileira de Farmacognosia-Brazilian Journal of Pharmacognosy.2023 Dec;:

• 77. [IF=5.6] Yan Lei et al."Elucidating the pharmacodynamic mechanisms of Yuquan pill in T2DM rats through comprehensive multi-omics analyses."Frontiers in Pharmacology.2023; 14: 1282077

• 76. [IF=6.1] Xiangnan Zhang et al."Effects of Fu brick tea polysaccharides on gut microbiota and fecal metabolites of HFD/STZ-induced type 2 diabetes rats."Food & Function.2023 Nov;:

• 75. [IF=7] Ma Zhouji et al."PDK4 rescues high-glucose-induced senescent fibroblasts and promotes diabetic wound healing through enhancing glycolysis and regulating YAP and JNK pathway."Cell Death Discovery.2023 Nov;9(1):1-15

• 74. [IF=4.1] Xijie Zhou et al."The bone mesenchymal stem cell-derived exosomal miR-146a-5p promotes diabetic wound healing in mice via macrophage M1/M2 polarization."MOLECULAR AND CELLULAR ENDOCRINOLOGY.2023 Oct;:112089

• 73. [IF=2.7] Shuanji Ou et al."Tibial cortex transverse transport potentiates diabetic wound healing via activation of SDF-1/CXCR4 signaling."PeerJ.10.7717/peerj.15894

• 72. [IF=4.8] Zhouji Ma et al."PDK4 facilitates fibroblast functions and diabetic wound healing through regulation of HIF-1α protein stability and gene expression."FASEB JOURNAL.10.1096/fj.202300874RR

• 71. [IF=5.1] Ligen Chen et al."Hyperglycemia symptom amelioration by Ascophyllum nodosum polysaccharides in mice with type 2 diabetes."Algal Research-Biomass Biofuels and Bioproducts.10.1016/j.algal.2023.103278

• 70. [IF=5.8] Jingyu He et al."Guard against internal and external: An antibacterial, anti-inflammation and healing-promoting spray gel based on lyotropic liquid crystals for the treatment of diabetic wound."INTERNATIONAL JOURNAL OF PHARMACEUTICS.10.1016/j.ijpharm.2023.

• 69. [IF=3.222] Pengmin Ji et al."Ginsenoside Rg1 treatment alleviates renal fibrosis by inhibiting the NOX4–MAPK pathway in T2DM mice."RENAL FAILURE.2023;45(1):Article: 2197075

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• 67. [IF=3.2] Han Qingyue et al."Hippocampal transcriptome analysis reveals mechanisms of cognitive impairment in beagle dogs with type 1 diabetes."JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY.2023 Aug;:

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• 63. [IF=7.9] Yinhui Mao et al."Combining transcriptomic analysis and network pharmacology to explore the mechanism by which Shaofu Zhuyu decoction improves diabetes mellitus erectile dysfunction."PHYTOMEDICINE.2023 Oct;119:155006

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• 58. [6.317] Yunfeng Zhao et al."Onchidium struma polysaccharides exhibit hypoglycemic activity and modulate the gut microbiota in mice with type 2 diabetes mellitus."Food & Function.2023 Jan;:

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• 56. [4.026] Lu, Wenjie et al."Metformin Hydrochloride Mucosal Nanoparticles-Based Enteric Capsule for Prolonged Intestinal Residence Time, Improved Bioavailability, and Hypoglycemic Effect."AAPS PHARMSCITECH.2023 Jan;24(1):1-14

• 55. [8.025] Gang Xiang et al."Antioxidant and hypoglycemic activity of tea polysaccharides with different degrees of fermentation."INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES.2022 Dec;:

• 54. [5.195] Yuli Han et al."Ginsenoside Rg1 attenuates glomerular fibrosis by inhibiting CD36/TRPC6/NFAT2 signaling in type 2 diabetes mellitus mice."JOURNAL OF ETHNOPHARMACOLOGY.2022 Nov;:115923

• 53. [IF=6.317] Zirui Huang et al."Sanghuangporus vaninii mixture ameliorated type 2 diabetes mellitus and altered intestinal microbiota in mice."Food & Function.2022 Oct;:

• 52. [IF=5.223] Zimu Zhang et al."Intestinal microbiology and metabolomics of streptozotocin-induced type 2 diabetes mice by polysaccharide from Cardamine violifolia."Journal of Functional Foods.2022 Oct;97:105251

• 51. [IF=3.246] Qingyue Han et al."Repeated Low-Dose Streptozotocin and Alloxan Induced Long-Term and Stable Type 1 Diabetes Model in Beagle Dogs."Biomed Research International.2022 Aug 08;2022:5422287

• 50. [IF=3.842] Qin Tingyu et al."Downregulation of glycoprotein non-metastatic melanoma protein B prevents high glucose-induced angiogenesis in diabetic retinopathy."MOLECULAR AND CELLULAR BIOCHEMISTRY.2022 Aug;:1-10

• 49. [IF=3.333] Junhao Huang et al."Shen Qi Wan Ameliorates Learning and Memory Impairment Induced by STZ in AD Rats through PI3K/AKT Pathway."Brain Sciences.2022 Jun;12(6):758

• 48. [IF=6.317] Mubai Sun et al."Black bean husk and black rice anthocyanin extracts modulated gut microbiota and serum metabolites for improvement in type 2 diabetic rats."Food & Function.2022 Jun;:

• 47. [IF=6.78] Min Liu et al."3,4-Dihydroxyphenylacetic acid ameliorates gut barrier dysfunction via regulation of MAPK-MLCK pathway in type 2 diabetes mice."LIFE SCIENCES.2022 Sep;305:120742

• 46. [IF=3.639] Min Liu et al."Peanut Skin Procyanidins Ameliorates Insulin resistance via Modulation of Gut Microbiota and Gut Barrier in Type 2 Diabetic Mice."JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

• 45. [IF=6.953] Lan Pang et al."Two glycoproteins from medicinal insect Periplaneta americana (L.) promote diabetic wound healing via macrophage polarization modulation."INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES. 2022 Jun;209:2130

• 44. [IF=6.953] Qian Liao et al."Characterization and diabetic wound healing benefits of protein-polysaccharide complexes isolated from an animal ethno-medicine Periplaneta americana L.."Int J Biol Macromol. 2022 Jan;195:466

• 43. [IF=9.381] Yuanping Hao et al."Carboxymethyl chitosan-based hydrogels containing fibroblast growth factors for triggering diabetic wound healing."Carbohyd Polym. 2022 Jul;287:119336

• 42. [IF=6.843] Shilu Ji et al."An oxygen-sensitive probe and a hydrogel for optical imaging and photodynamic antimicrobial chemotherapy of chronic wounds."Biomater Sci-Uk. 2022 Apr;10(8):2054-2061

• 41. [IF=1.779] Shan-Na Chen et al."Protective effect of LIF-huMSCs on the retina of diabetic model rats."Int J Ophthalmol-Chi. 2021; 14(10): 1508–1517

• 40. [IF=2.952] Yunfeng Zhu et al."Astragaloside IV alleviates liver injury in type 2 diabetes due to promotion of AMPK/mTOR‑mediated autophagy."Mol Med Rep. 2021 Jun;23(6):1-12

• 39. [IF=4.219] Zhenlong Qin et al."Analysis of the analgesic effects of tricyclic antidepressants on neuropathic pain, diabetic neuropathic pain, and fibromyalgia in rat models."Saudi J Biol Sci. 2020 Sep;27:2485

• 38. [IF=4.545] Zhongyuan Wang et al."Protective effects of AS-IV on diabetic cardiomyopathy by improving myocardial lipid metabolism in rat models of T2DM."Biomed Pharmacother. 2020 Jul;127:110081

• 37. [IF=5.037] Mengyuan Fang et al."Asiatic acid attenuates diabetic retinopathy through TLR4/MyD88/NF-κB p65 mediated modulation of microglia polarization."Life Sci. 2021 Jul;277:119567

• 36. [IF=5.396] Yue Ding et al."Combination of honey with metformin enhances glucose metabolism and ameliorates hepatic and nephritic dysfunction in STZ-induced diabetic mice."Food Funct. 2019 Nov;10(11):7576-7587

• 35. [IF=5.396] Jun-ping Liu et al."Antidiabetic activities of glycoprotein from pea (Pisum sativum L.) in STZ-induced diabetic mice."Food Funct. 2021 Jun;12(11):5087-5095

• 34. [IF=5.396] Xiaopeng Li et al."Diabetes diminishes a typical metabolite of litchi pericarp oligomeric procyanidins (LPOPC) in urine mediated by imbalanced gut microbiota."Food Funct. 2021 Jun;12(12):5375-5386

• 33. [IF=1.902] Yukun Feng et al."Validated LC-MS method for simultaneous quantitation of catalpol and harpagide in rat plasma: application to a comparative pharmacokinetic study in normal and diabetic rats after oral administration of Zeng-Ye-Decoction."Biomed Chromatog

• 32. [IF=3.701] Xiaopeng Li et al."A-type procyanidins from litchi pericarp ameliorate hyperglycaemia by regulating hepatic and muscle glucose metabolism in streptozotocin (STZ)-induced diabetic mice fed with high fat diet."J Funct Foods. 2016 Dec;27:711

• 31. [IF=4.192] Xiaopeng Li et al."Attenuated mTOR Signaling and Enhanced Glucose Homeostasis by Dietary Supplementation with Lotus Seedpod Oligomeric Procyanidins in Streptozotocin (STZ)-Induced Diabetic Mice."J Agr Food Chem. 2017;65(19):3801–3810

• 30. [IF=4.451] Xiaopeng Li et al."Dietary supplementation of A-type procyanidins from litchi pericarp improves glucose homeostasis by modulating mTOR signaling and oxidative stress in diabetic ICR mice."J Funct Foods. 2018 May;44:155

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• 25. Li, Xiaopeng, et al. "A-type procyanidins from litchi pericarp ameliorate hyperglycaemia by regulating hepatic and muscle glucose metabolism in streptozotocin (STZ)-induced diabetic mice fed with high fat diet." Journal of Functional Foods 27 (2016): 711-7

• 24. Ding, Yue, et al. "Combination of honey with metformin enhances glucose metabolism and ameliorates hepatic and nephritic dysfunction in STZ-induced diabetic mice." Food & function 10.11 (2019): 7576-7587.https://doi.org/10.1039/C9FO01575B

• 23. Jayachandran, Muthukumaran, Ramachandran Vinayagam, and Baojun Xu. "Guava leaves extract ameliorates STZ induced diabetes mellitus via activation of PI3K/AKT signaling in skeletal muscle of rats." Molecular biology reports 47.4 (2020): 2793-2799.

• 22. Wei Xu, Qing Zhou, Jiao-jiao Yin, Yong Yao, Jiu-liang Zhang, Anti-diabetic effects of polysaccharides from Talinum triangulare in streptozotocin (STZ)-induced type 2 diabetic male mice, International Journal of Biological Macromolecules, Volume 72, 2015, P

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• 19. 闫爽,李光耀,戴丛书,崔昊震,柳振宇,林长青.人参皂苷CK对2型糖尿病大鼠肝损伤的保护机制[J].食品工业科技,2021,42(02):310-315.

• 18. 随风,时昭红.胰高血糖样肽1对非酒精性脂肪肝大鼠CFHR1～5表达的影响[J].中国免疫学杂志,2021,37(01):36-40.

• 17. 季天娇. 黄芪甲苷调节PI3K/Akt通路来改善2型糖尿病大鼠肝糖代谢异常的分子机制[D].安徽医科大学,2020.

• 16. 马可可,鞠营辉,陈清青,李维祖,李卫平.黄芪甲苷对2型糖尿病肾病大鼠肾组织PI3K/Akt/FoxO1信号调控的影响[J].中国实验方剂学杂志,2019,25(02):74-81.

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• 13. 张哲滔,车念聪,郑亚琳,田甜,魏晓艺,刘晔.菖蒲郁金汤化裁方对2型糖尿病合并非酒精性脂肪肝大鼠SREBP-1c表达和胰岛素抵抗的影响[J].北京中医药,2019,38(01):17-20+97.

• 12. 王海生, 谢永财, 李长征,等. 石斛合剂对高脂高糖糖尿病大鼠心肌细胞Ca2+代谢的影响[J]. 福建中医药, 2020, 051(001):47-50.

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• 10. 伏瑶,周继栋,桑晓宇,孙笛洋,赵启韬,傅风华.瓜蒌薤白半夏汤对2型糖尿病合并急性心肌缺血大鼠造血干细胞的保护作用机制[J].中华中医药杂志,2020,35(05):2613-2617.

• 9. 汤陈鹏, 吕峰, 刘伊娜. 孔石莼多糖锌对Ⅰ型糖尿病小鼠糖脂代谢及体内抗氧化的干预作用[J]. 食品工业科技, 2020, v.41;No.441(01):301-306+315.

• 8. 胡江, 缪菁, 段淑芳,等. 大黄酸对2型糖尿病模型大鼠的保护作用[J]. 中国药房, 2014, 025(023):2113-2116.

• 7. 杨文超, 顾正位, 路其康,等. 复方葛根片对糖尿病肾病模型大鼠肾组织的保护作用[J]. 中国药房, 2015(34).

• 6. 孙昕, 刘卫. 复方川芎滴丸对糖尿病肾病模型大鼠血液流变学及血气的影响[J]. 中国药房, 2017(7).

• 5. 崔祥,尚尔鑫,江曙,钱大玮,段金廒.基于响应曲面法对黄芩-黄连配伍改善2型糖尿病糖脂代谢紊乱的相互作用研究[J].药学学报,2018,53(04):630-635.

• 4. 张文锦 方朝晖 赵媛媛 等. 启元胶囊对糖尿病模型大鼠周围神经病变干预机制[J]. 中医药临床杂志 2019 v.31(11):120-123.

• 3. 吉艳梅 文彩铃.六味地黄丸联合胰岛素对妊娠糖尿病大鼠血清皮质酮及胎盘11β-羟基类固醇脱氢酶表达的影响[J].解放军药学学报 2018 34(03):221-224+253.

• 2. 周国佩 吴帆 朱金华 et al. 乌梅丸对2型糖尿病模型大鼠肠道菌群 炎性因子及短链脂肪酸的影响[J]. 中国实验方剂学杂志 2020(10).

• 1. 朱戈丽 伍军 张艳霞 等. miR-21介导PTEN/SMAD7信号传导通路调控糖尿病肾病大鼠肾纤维化作用研究[J]. 临床误诊误治 2020年33卷7期 104-108页 ISTIC 2020.

输入产品批号：

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *