S26102 |
PS 48 |
| MedMol | 98% |
- 产品描述： PS-48 是 phosphoinositide-dependent protein kinase-1 (PDK1) 的变构激活剂
- 靶点： PDK1
- 体内研究： In vivo, the PDK1 agonist PS48 can maintain the bone mass of mice treated with dexamethasone
- 细胞实验： Cell lines: MC3T3-E1 cells Concentrations: 5 μM Incubation Time: -- Method: MC3T3-E1 cells are cultured in an osteogenic differentiation medium containing 4 mM glycerophosphate and 25 μg/mL ascorbic acid until 70% confluency. Dexamethasone (final concentration of ethanol, 0.01%, vol/vol) at different concentrations is then added to the osteogenic differentiation medium for 14 days. The culture medium is replaced every two days. MC3T3-E1 cells are cultured in a culture medium containing 10−7 M dexamethasone supplemented with or without PS48 (5 μM).
- 动物实验： Animal Models: 8-week-old male C57BL/6J mice Dosages: -- Administration: --
- 参考文献：
1. Valerie Hindie, et al.Nat Chem Biol. 2009 Oct;5(10):758-64. 2. Wen-Ning Xu, et al. Front Endocrinol (Lausanne). 2020 Jan 28;10:922.
- 溶解性： Soluble in DMSO、Ethanol
- 保存条件： -20℃
- 配置溶液浓度参考：
1mg 5mg 10mg 1 mM 3.487 ml 17.437 ml 34.873 ml 5 mM 0.697 ml 3.487 ml 6.975 ml 10 mM 0.349 ml 1.744 ml 3.487 ml 50 mM 0.07 ml 0.349 ml 0.697 ml
- 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。
输入产品批号：
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)
