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S28059

Semaglutide

MedMol 98%
  • 英文名:
  • L-Histidyl-2-methylalanyl-L-alpha-glutamylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-alpha-aspartyl-L-valyl-L-seryl-L-seryl-L-tyrosyl-L-leucyl-L-alpha-glutamylglycyl-L-glutaminyl-L-alanyl-L
  • 别名:
  • Semaglutide
  • CAS号:
  • 910463-68-2
  • 分子式:
  • C187H291N45O59
  • 分子量:
  • ~4113.6
货号产品规格市场价(RMB)您的折扣价(RMB)库存(上海) 北京 武汉 南京 数量计量单位 加入购物车...
S28059-1mg 98% ¥2200.00元 ¥935.00元 >10 0 0 0 EA 加入购物车
S28059-5mg 98% ¥6000.00元 ¥2890.00元 >10 0 0 0 EA 加入购物车
S28059-10mg 98% ¥6500.00元 ¥5525.00元 6 0 0 0 EA 加入购物车
S28059-25mg 98% ¥14000.00元 ¥11900.00元 >10 0 0 0 EA 加入购物车
S28059-100mg 98% ¥35000.00元 ¥29750.00元 >10 0 0 0 EA 加入购物车
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  • 产品描述:

    Semaglutide, a long-acting GLP-1 analogue, is a glucagon-like peptide-1 (GLP-1) receptor agonist. Semaglutide has the potential for type 2 diabetes treatment.

  • 靶点: GLP-1 receptor
  • 体外研究: Semaglutide has two amino acid substitutions compared to human GLP-1 (Aib8, Arg34) and is derivatized at lysine 26. The GLP-1R affinity of Semaglutide is 0.38±0.06 nM. Semaglutide is a GLP-1 analogue with 94% sequence omology to human GLP-1.
  • 体内研究: The plasma half-life of Semaglutide is 46h in mini-pigs following i.v. administration and semaglutide has an MRT of 63.6h after s.c. dosing to mini-pigs. Semaglutide improves 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP)-induced motor impairments. In addition, Semaglutide rescues the decrease of tyrosine hydroxylase (TH) levels, alleviates the inflammation response, reduces lipid peroxidation, inhibits the apoptosis pathway, and also increases autophagy- related protein expression, to protect dopaminergic neurons in the substantia nigra and striatum. Moreover, the long-acting GLP-1 analogue semaglutide is superior to NN-2211 in most parameters.
  • 参考文献:
    1. Marso SP, et al. Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes. N Engl J Med. 2016 Nov 10;375(19):1834-1844. 2. Zhang L, et al. Neuroprotective effects of the novel GLP-1 long acting analogue semaglutide in the MPTP Parkinson's disease mouse model. Neuropeptides. 2018 Oct;71:70-80. 3. Dhillon S, et al. Semaglutide: First Global Approval. Drugs. 2018 Feb;78(2):275-284.
  • 溶解性: Soluble  in  DMSO、H2O(用HCL  调节,pH≈1)
  • 保存条件: -20℃
  • 配置溶液浓度参考:
    1mg 5mg 10mg
    1 mM 0 ml 0 ml 0 ml
    5 mM 0 ml 0 ml 0 ml
    10 mM 0 ml 0 ml 0 ml
    50 mM 0 ml 0 ml 0 ml
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