S80008 |
Sodium picosulfate |
| MedMol | 99% |
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- 产品描述： Sodium Picosulfate inhibits absorption of water and electrolytes, and increases their secretion.
- 体内研究： Sodium Picosulphate treatment for long-term has no effects on neuropeptide content of the rat colon. Over a 6-month period, daily doses (10 mg/kg/day) or twice-weekly doses (7.5 mg/kg/day) of Sodium Picosulphate do not affect the level of Vasoactive intestinal polypeptide (VIP), somatostatin, and substance P in mucosa, submucosa, or muscularis externa.Sodium Picosulphate has no major influence on ileal and colonic epithelial cell proliferation. In a 12 weeks study, 10 mg/kg Sodium Picosulphate continuously treatment does not influence the labeling index of Brdu (LI) in the ileum and induces no statistically significant increase of the LI when the treated groups are compared with the control group. The proliferative pattern along the crypts remains unchanged with sodium picosulphate treatment throughout the study.Sodium Picosulphate does not induce chronic changes in colonic motility in rats under long-term treatment. 10 mg/kg/day Sodium Picosulphate pretreated for 23 weeks does not induce any significant change in the duration of long spike bursts (LSB) which are associated with phasic contractions, or in LSB frequency in the fasted state or after a 3-gram meal.
- 参考文献：
1.Geboes K, et al. Pharmacology, 1993, 47 Suppl 1, 187-195. 2.Fioramonti J, et al. Pharmacology, 1993, 47 Suppl 1, 155-161. 3.Nishikawa J, et al. Arzneimittelforschung, 1981, 31(2), 321-325. 4.Tzavella K, et al. Eur J Gastroenterol Hepatol, 1995, 7(1), 13-20.
- 溶解性： Ethanol:3 mg/mL (6.23 mM) DMSO:89 mg/mL (184.9 mM) H2O:88 mg/mL (182.8 mM)
- 保存条件： -20℃
- 配置溶液浓度参考：
1mg 5mg 10mg 1 mM 2.077 ml 10.386 ml 20.772 ml 5 mM 0.415 ml 2.077 ml 4.154 ml 10 mM 0.208 ml 1.039 ml 2.077 ml 50 mM 0.042 ml 0.208 ml 0.415 ml
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)
