• 介绍：

   Gemcitabine (LY 188011) 是一种嘧啶核苷类似物抗代谢药 (nucleoside antimetabolite/analog) 和抗肿瘤剂。Gemcitabine 抑制 DNA 合成 (DNA synthesis) 和修复，导致细胞自噬 (autophagy) 和凋亡 (apoptosis)

• 熔点： 168.64 °C

• 沸点： 482.7°C at 760 mmHg

• 比旋光度： 365 +425.36°; D +71.51°

• 外观： 粉末

• 溶解性： DMSO  :  250  mg/mL  (949.85  mM;  Need  ultrasonic)
  
  Ethanol  :  12.5  mg/mL  (47.49  mM;  Need  ultrasonic)
  
  H2O  :  6.25  mg/mL  (23.75  mM;  ultrasonic  and  warming  and  heat  to  60°C)

• 储存条件： 2-8℃

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

• 5. [3] Silli Epiphane K. et al."Design optimization of Fucoidan-coating Cationic Liposomes for enhance Gemcitabine delivery."INVESTIGATIONAL NEW DRUGS.2024 Aug;:1-13

• 4. [5.062] Mengfei Li et al."FU-coating pH-sensitive liposomes for improving the release of gemcitabine by endosome escape in pancreatic cancer cells."JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY.2023 Feb;80:104135

• 3. [IF=8.039] Haohao Wang et al."Seco-Lupane Triterpene Derivatives Induce Ferroptosis through GPX4/ACSL4 Axis and Target Cyclin D1 to Block the Cell Cycle."JOURNAL OF MEDICINAL CHEMISTRY.2022;XXXX(XXX):XXX-XXX

• 2. [IF=2.311] Shanshan Jiang et al."Combination treatment of gemcitabine and sorafenib exerts a synergistic inhibitory effect on non‑small cell lung cancer in vitro and in vivo via the epithelial‑to‑mesenchymal transition process."Oncol Lett. 2020 Jul;20(1):346-356

• 1. [IF=6.304] Xiong Qiao et al."Cuprous oxide nanoparticles trigger reactive oxygen species-induced apoptosis through activation of erk-dependent autophagy in bladder cancer."Cell Death Dis. 2020 May;11(5):1-13

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *