S80079 |
Pyridostatin trifluoroacetate salt |
| 源叶(MedMol) | 98% |
- 英文名：
- Pyridostatin trifluoroacetate salt
- 别名：
- 4-(2-Aminoethoxy)-N2,N6-bis[4-(2-aminoethoxy)-2-quinolinyl]-2,6-pyridinedicarboxamide trifluoroacetate salt, RR82 trifluoroacetate salt
- CAS号：
- 1472611-44-1
- 分子式：
- C31H32N8O5·xC2HF3O2
- 分子量：
- 596.64 (free base basis)
- 核磁/质谱：
-
产品介绍
参考文献
质检证书(COA)
摩尔浓度计算器
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- 提示：详情请下载说明书。
- 产品描述： Pyridostatin Trifluoroacetate Salt is a G-quadruplexe stabilizer with Kd of 490 nM in a cell-free assay, which targets a series of proto-oncogenes including c-kit, K-ras and Bcl-2.
- 靶点： DNA/RNA Synthesis;DNA/RNASynthesis
- 细胞实验： Cell lines: MRC-5–SV40 cells and various cancer cell linesConcentrations: 10 μMIncubation Time: 48 hMethod: Cells are plated at equal confluence and are left either untreated or were treated with 2 μM pyridostatin continually during the indicated time before harvesting the cells. Cells from individual plates are trypsinized and counted in a Coulter counter. Graphs represent the total cell numbers at each time interval, and the error bars represent the s.e.m. Data represent three independent experiments.
- 参考文献：
1.Rodriguez R,etal. Small-molecule-induced DNA damage identifies alternative DNA structures in human genes.Nat Chem Biol. 2012 Feb 5;8(3):301-10. 2.Murat P,etal.G-quadruplexes regulate Epstein-Barr virus-encoded nuclear antigen 1 mRNA translation.Nat Chem Biol. 2014 May;10(5):358-64. 3.Koirala D,etal.A single-molecule platform for investigation of interactions between G-quadruplexes and small-molecule ligands.Nat Chem. 2011 Aug 28;3(10):782-7.
- 溶解性： DMSO:90 mg/mL (95.88 mM)
- 保存条件： -20℃
- 配置溶液浓度参考：
1mg 5mg 10mg 1 mM 0 ml 0 ml 0 ml 5 mM 0 ml 0 ml 0 ml 10 mM 0 ml 0 ml 0 ml 50 mM 0 ml 0 ml 0 ml
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