| 产品描述： | Helioxanthin 8-1, an analogue of helioxanthin, exhibits significant in vitro anti-HBV/HCV/HSV-1/HIV activity with EC50 of >5/10/1.4/15 μM. |
| 体外研究： |
The cyclic hydrazide 28(Helioxanthin 8-1) showed the most potent anti-HBV activity among those helioxanthin analogues tested. In addition, compound 28 exhibited moderately potent activity against HIV. It would therefore be promising to study helioxanthin analogues that contain a six-membered ring instead of the five-membered ring found in the lactam. 8-1 exhibited effective inhibition on DHBV replication. The combination of 8-1 with 3TC resulted in the additional anti-DHBV activity. Viral induced cells displayed higher susceptibility to 8-1 treatment than non-induced cells. HBV X protein might not be an essential factor in the initiation of the biological activity of 8-1, as demonstrated by its absence in DHBV |
| 参考文献： |
1. Ying C, et al. Helioxanthin analogue 8-1 inhibits duck hepatitis B virus replication in cell culture. Antivir Chem Chemother. 2010;21(2):97-103. 2. Yeo H, et al. Synthesis and antiviral activity of helioxanthin analogues. J Med Chem. 2005 Jan 27;48(2):534-46. |
| 溶解性： |
soluble in DMSO |
| 保存条件： |
-20℃ |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
2.657 ml |
13.287 ml |
26.573 ml |
| 5 mM |
0.531 ml |
2.657 ml |
5.315 ml |
| 10 mM |
0.266 ml |
1.329 ml |
2.657 ml |
| 50 mM |
0.053 ml |
0.266 ml |
0.531 ml |
|
| 注意： |
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上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京