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• 产品描述： Tropisetron (ICS 205-930) is a 5-HT3 receptor antagonist and α7-nicotinic receptor agonist with an IC50 of 70.1 ± 0.9 nM for 5-HT3 receptor

• 靶点： 5-HT3 receptor:5.3 nM(Ki);α7 nAChR:6.9 nM(Ki);5-HTReceptor;AChR

• 体内研究：
  Tropisetron could ameliorate the ischemic brain injury via decreasing myeloperoxidase activity and TNF-α level. Tropisetron elicits anti-inflammatory effects in experimental model of cisplatin-induced nephrotoxicity and these effects were completely 5-HT3-receptor-independent

• 细胞实验： Cell lines: Jurkat cells Concentrations: 10, 25, 50 μg/ml Incubation Time: 30 min Method: Jurkat cells (1 × 106 cells/ml) were stimulated with either TNFα (2 ng/ml) or PMA (20 ng/ml) plus ionomycin (0.5 ug/ml) for p65, JNK, ERK1 + 2, p38 and IκBα proteins in the presence or absence of tropisetron. Cells were then washed with PBS and proteins extracted in 50 μl of lysis buffer containing 0.5% NP-40. Protein concentration was determined by the Bradford assay and 30 μg of proteins were boiled in Laemmli buffer and electrophoresed in 10% SDS/polyacrylamide gels.

• 动物实验： Animal Models: Male albino mice Dosages: 3 mg/kg Administration: i.p.

• 参考文献：
  1. Macor JE, et al. Bioorg Med Chem Lett. 2001, 11(3):319-21. 2. Vega Lde L, et al. Biochem Pharmacol. 2005, 70(3):369-80. 3. Zirak MR, et al. Eur J Pharmacol. 2014, 738:222-9.

• 溶解性： Soluble  in  DMSO、H2O

• 保存条件： 2-8℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	3.517 ml	17.584 ml	35.168 ml
  5 mM	0.703 ml	3.517 ml	7.034 ml
  10 mM	0.352 ml	1.758 ml	3.517 ml
  50 mM	0.07 ml	0.352 ml	0.703 ml

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *