46. [IF=4.8] Wei Li et al."Kaempferol modulates ɑ2M secretion in bone marrow-derived macrophages by downregulating GR/PER1-mediated lipid metabolism to attenuate the emotional stress-aggravated metastasis of prostate cancer."JOURNAL OF ETHNOPHARMACOLOGY.2025 Jan;339:1 45. [IF=4.1] Shengwei Zhou et al."Suitable concentrations of brassinolide application enhances growth performance and saikosaponin biosynthesis by transcriptional activation of triterpenoid pathway genes in Bupleurum chinense DC."Frontiers in Plant Science.2025 Mar;16 44. [IF=4.4] Nan Li et al."Wuling capsule alleviates hyperuricaemia and protects UA- injured HK-2 cells by regulating uric acid transporter proteins."Frontiers in Pharmacology.2025 Apr;16: 43. [IF=5.4] Ruolan Sun et al."Homotherapy-for-heteropathy of Bupleurum Chinense DC.-Scutellaria baicalensis Georgi in treating depression and colorectal cancer: A network pharmacology and animal model approach."JOURNAL OF ETHNOPHARMACOLOGY".2024 Mar;:118038 42. [IF=3.4] Jiaxin Yin et al."Comprehensive multicomponent characterization and quality assessment of Xiaoyao Wan by UPLC-Q-Orbitrap-MS, HS-SPME-GC-MS and HS-GC-IMS."JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS.2024 Feb;239:115910 41. [IF=4.1] Liangliang He et al."A multi-module structure labelled molecular network orients the chemical profiles of traditional Chinese medicine prescriptions: Xiaoyao San, as an example."JOURNAL OF CHROMATOGRAPHY A.2024 Jan;1715:464613 40. [IF=5.4] Liangxin Zhao et al."UPLC-Q-Exactive/MS based analysis explore the correlation between components variations and anti-influenza virus effect of four quantified extracts of Chaihu Guizhi decoction."JOURNAL OF ETHNOPHARMACOLOGY.2023 Oct;:117318 39. [IF=2.6] Liu Xueqi et al."In Vivo Evaluation of Self-assembled nano-Saikosaponin-a for Epilepsy Treatment."MOLECULAR BIOTECHNOLOGY.2023 Aug;:1-11 38. [IF=4.6] Zhenhuan Wang et al."Quantitative and Differential Analysis between Bupleurum chinense DC. and Bupleurum scorzonerifolium Willd. Using HPLC-MS and GC-MS Coupled with Multivariate Statistical Analysis."MOLECULES.2023 Jan;28(15):5630 37. [IF=3.1] Tian Lan et al."Saikosaponin A triggers cell ferroptosis in hepatocellular carcinoma by inducing endoplasmic reticulum stress-stimulated ATF3 expression."BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS.2023 Sep;674:10 36. [IF=5.4] Jie Tang et al."Study on the mechanism of Shuganzhi Tablet against nonalcoholic fatty liver disease and lipid regulation effects of its main substances in vitro."JOURNAL OF ETHNOPHARMACOLOGY.2023 Nov;316:116780 35. [IF=4.141] Yiqing Peng et al."Assessment of Genetic Diversity in Bupleurum spp. Basing Agronomic Traits, Medicinal Components and ISSR Markers."Genes.2023 Apr;14(4):951 34. [IF=6.656] Minna Huang et al."Saikosaponin A and D attenuate skeletal muscle atrophy in chronic kidney disease by reducing oxidative stress through activation of PI3K/AKT/Nrf2 pathway."PHYTOMEDICINE.2023 Jun;114:154766 33. [IF=3.369] Li Liu et al."Effects of Trichoderma harzianum biofertilizer on growth, yield, and quality of Bupleurum chinense."Plant Direct.2022 Nov;6(11):e461 32. [IF=9.756] Jiling Feng et al."Saikosaponin A enhances Docetaxel efficacy by selectively inducing death of dormant prostate cancer cells through excessive autophagy."CANCER LETTERS.2023 Feb;554:216011 31. [IF=5.168] Pan Wang et al."Discovery and characterization of novel ATP citrate lyase inhibitors from natural products by a luminescence-based assay."CHEMICO-BIOLOGICAL INTERACTIONS.2022 Nov;367:110199 30. [IF=4.927] Linlin Yang et al."Drought Stress Stimulates the Terpenoid Backbone and Triterpenoid Biosynthesis Pathway to Promote the Synthesis of Saikosaponin in Bupleurum chinense DC. Roots."MOLECULES.2022 Jan;27(17):5470 29. [IF=2.977] An-rong Wang et al."Saikosaponin A improved depression-like behavior and inhibited hippocampal neuronal apoptosis after cerebral ischemia through p-CREB/BDNF pathway."Behav Brain Res. 2021 Apr;403:113138 28. [IF=3] Qu Lala et al."Phenotypic assessment and ligand screening of ETA/ETB receptors with label-free dynamic mass redistribution assay."N-S Arch Pharmacol. 2020 Jun;393(6):937-950 27. [IF=3.205] Jie Tang et al."Metabolite profiling of Shuganzhi tablets in rats and pharmacokinetics study of four bioactive compounds with liquid chromatography combined with electrospray ionization tandem mass spectrometry."J Chromatogr B. 2021 Aug;1179:122827 26. [IF=4.36] Xiaojing Zhang et al."A new discovery: Total Bupleurum saponin extracts can inhibit the proliferation and induce apoptosis of colon cancer cells by regulating the PI3K/Akt/mTOR pathway."J Ethnopharmacol. 2022 Jan;283:114742 25. [IF=4.534] Jikun Du et al."Saikosaponin-A induces apoptosis of cervical cancer through mitochondria- and endoplasmic reticulum stress-dependent pathway in vitro and in vivo: involvement of PI3K/AKT signaling pathway."Cell Cycle. 2021;20(21):2221-2232 24. [IF=5.81] Cui Lihua et al."Chaihu Guizhi Ganjiang Decoction Ameliorates Pancreatic Fibrosis via JNK/mTOR Signaling Pathway."Front Pharmacol. 2021 Jun;0:1369 23. [IF=3.205] Zhuangzhuang Li et al."Simultaneous quantification of fifteen compounds in rat plasma by LC-MS/MS and its application to a pharmacokinetic study of Chaihu-Guizhi decoction."J Chromatogr B. 2019 Jan;1105:15 22. [IF=3.216] Yu Hong et al."Saikosaponin A modulates remodeling of Kv4.2-mediated A-type voltage-gated potassium currents in rat chronic temporal lobe epilepsy."Drug Des Dev Ther. 2018; 12: 2945–2958 21. [IF=4.411] Dan-Dan Tian et al."Pharmacokinetic Evaluation of Clozapine in Concomitant Use of Radix Rehmanniae, Fructus Schisandrae, Radix Bupleuri, or Fructus Gardeniae in Rats."Molecules. 2016 Jun;21(6):696 20. [IF=4.411] Wei Wang et al."In Vitro Effects of Concomitant Use of Herbal Preparations on Cytochrome P450s Involved in Clozapine Metabolism."Molecules. 2016 May;21(5):597 19. Wang, Wei, Dan-Dan Tian, and Zhang-Jin Zhang. "In Vitro Effects of Concomitant Use of Herbal Preparations on Cytochrome P450s Involved in Clozapine Metabolism." Molecules 21.5 (2016): 597.https://doi.org/10.3390/molecules21050597 18. Tian D-D, Wang W, Wang H-N, Sze SCW, Zhang Z-J. Pharmacokinetic Evaluation of Clozapine in Concomitant Use of Radix Rehmanniae, Fructus Schisandrae, Radix Bupleuri, or Fructus Gardeniae in Rats. Molecules. 2016; 21(6):696. https://doi.org/10.3390/molecules 17. 李壮壮, 张静, 赵绍哲,等. 指纹图谱与化学计量学结合优选柴胡桂枝颗粒水提工艺[J]. 中成药, 2018, v.40(08):199-203. 16. 黄湘 陈丰连 曹骋 等. HPLC-ELSD全成分指纹图谱研究疏肝理脾方配伍前后化学成分的变化[J]. 化学与生物工程 2020 037(001):59-64. 15. 杨梦玲, 尤朋涛, 何丽珊,等. 基于UPLC-MS/MS分析胃溃疡模型大鼠口服加味小柴胡颗粒后血浆中8种有效成分的药代动力学[J]. 中国中药杂志, 2018, 43(18). 14. 赵昕彤, 辛国, 辛宇,等. 煎煮时间对柴胡中柴胡皂苷A和柴胡皂苷D含量的影响[J]. 人参研究, 2017. 13. 廖念, 庞雪, 周逸群,等. 正交试验法优选北柴胡麸炒工艺[J]. 中国药师, 2017, 020(004):738-740. 12. 潘龙,牛俊丽,卜登攀,杜洪,程建波,孙先枝,王秀敏,秦俊杰,袁耀明,张幸开.柴胡皂苷对体外发酵参数及细菌数量变化的影响[J].草业学报,2015,24(06):85-91. 11. 朱双龙,陈旭义,段会全,刘迎节,孙中磊,徐云强.柴胡皂苷a影响大鼠急性脊髓损伤后机体炎症水平表达的实验研究[J].天津医科大学学报,2017,23(04):300-303. 10. 朱双龙, 段会全, 刘英富,等. 柴胡皂苷a对大鼠急性脊髓损伤的神经保护作用与机制研究[J]. 中国修复重建外科杂志, 2017, 031(007):825-829. 9. 胡冬蓉, 禤正正, 谢炜,等. 柴胡疏肝汤高效液相指纹图谱的建立及含量测定[J]. 时珍国医国药, 2017(6):1310-1314. 8. 曹雪, 蔡广知, 赵凌,等. 基于复合质量常数的北柴胡饮片等级评价[J]. 中国实验方剂学杂志, 2018(18). 7. 李英, 焦倩, 张天天,等. 基于地形因子的河北省北柴胡生态适宜性区划研究[J]. 中国中药杂志, 2017, 042(022):4402-4407. 6. 郭泰麟 李丹丹 张慧. 南北柴胡HPLC-ELSD指纹图谱的研究[J]. 中国民族民间医药 2020 029(006):19-24. 5. 廖念 庞雪 周逸群 等. 北柴胡麸煨工艺的正交试验法优选[J]. 时珍国医国药 2017(05):96-98. 4. 庞雪 廖念 周逸群 等. 不同炮制方法对北柴胡中柴胡皂苷含量的影响[J]. 时珍国医国药 2016(12):2906-2908. 3. 邱云 苏健 庞雪 等. 不同炮制方法对北柴胡中柴胡皂苷a、d的含量影响[J]. 湖南中医药大学学报 2016(2期):51-53. 2. 宁艳梅 杨秀娟 陈晖 张金保 杨韬 任远.不同比例鳖血炮制柴胡制品中柴胡总皂苷含量测定与比较[J].中兽医医药杂志 2019 38(05):9-13. 1. 辛国 赵昕彤 李文 等. 不同时间煎煮柴胡对五柴胡饮中柴胡皂苷含量及药效学的影响[J]. 长春中医药大学学报 2018(4):641-644.