69. [IF=4.7] Yijie Li et al."Anthraquinones of Cassiae Semen alleviate lipid accumulation in obesity by regulating brown adipose tissue and liver function."Chinese Herbal Medicines.2025 Feb;: 68. [IF=1.8] Shu Lianghui et al."Suyin Detoxification Prescription Regulates the Klotho and ERK/NF-κB Signaling Pathways to Alleviate Renal Injury."CELL BIOCHEMISTRY AND BIOPHYSICS.2025 Feb;:1-16 67. [IF=6.1] Jia Guo et al."Discovery of anthraquinones as potent Notum inhibitors for treating osteoporosis by integrating biochemical, phytochemical, computational, and experimental assays."Journal of Pharmaceutical Analysis.2025 Mar;:101256 66. [IF=4.8] Li He et al."Dunhuang Dabupi Decoction and its active components alleviate ulcerative colitis by activating glutathione metabolism and inhibiting JAK-STAT pathway in Drosophila and mice."JOURNAL OF ETHNOPHARMACOLOGY.2025 Apr;346:119717 65. [IF=4.7] Zhengyao Yu et al."Exploring the Therapeutic and Gut Microbiota-Modulating Effects of Qingreliangxuefang on IMQ-Induced Psoriasis."Drug Design Development and Therapy. 64. [IF=3.2] Qin Xin et al."Rhein alleviates MPTP-induced Parkinson’s disease by suppressing neuroinflammation via MAPK/IκB pathway."Frontiers in Neuroscience.2024 Jun;18: 63. [IF=1.4] Sunghanghwa Yuwathida et al."Plasmodium falciparum Lactate Dehydrogenase Inhibitory Activities of Pomegranate and Mangosteen Extracts and their Major Constituents."Revista Brasileira de Farmacognosia-Brazilian Journal of Pharmacognosy.2024 Jul;:1-10 62. [IF=4.9] Xiaoran Zhao et al."Constructing a hydrogel based on self-assembly properties of glycyrrhizic acid: A drug delivery system with digestive tract responsive."COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS.2024 Sep;697:134497 61. [IF=4.1] Xiaoyao Liu et al."The Water Extract of Rhubarb Prevents Ischemic Stroke by Regulating Gut Bacteria and Metabolic Pathways."Metabolites".2024 Apr;14(4):216 60. [IF=4.9] Zhao Xia et al."Comparative transcriptome analysis and identification of candidate R2R3-MYB genes involved in anthraquinone biosynthesis in Rheum palmatum L.."Chinese Medicine".2024 Dec;19(1):1-18 59. [IF=4.7] Xu Zhang et al."Rhein: A potent immunomodulator empowering largemouth bass against MSRV infection."FISH & SHELLFISH IMMUNOLOGY.2024 Jan;144:109284 58. [IF=5.4] Botong Li et al."Protective effect of San Huang Pill and its bioactive compounds against ulcerative colitis in Drosophila via modulation of JAK/STAT, apoptosis, Toll, and Nrf2/Keap1 pathways."JOURNAL OF ETHNOPHARMACOLOGY.2024 Mar;322:117578 57. [IF=2.9] Qi Ying et al."Sanhuang Xiexin Decoction Ameliorates TNBC By Modulating JAK2-STAT3 and Lipid Metabolism."Chinese Journal of Integrative Medicine.2023 Nov;:1-10 56. [IF=3.4] Si Li et al."Active ingredients of Erhuang Quzhi Granules for treating non-alcoholic fatty liver disease based on the NF-κB/NLRP3 pathway."FITOTERAPIA.2023 Dec;171:105704 55. [IF=4.5] Guangtao Pan et al."Dachengqi decoction ameliorates sepsis-induced liver injury by inhibiting the TGF-β1/Smad3 pathways."Journal of Traditional and Complementary Medicine.10.1016/j.jtcme.2023.09.001 54. [IF=4.601] Yuexuan Li et al."Facile and selective separation of anthraquinones by alizarin-modified iron oxide magnetic nanoparticles."JOURNAL OF CHROMATOGRAPHY A.2023 Aug;1702:464088 53. [IF=5.195] Si Li et al."Prediction and verification of the active ingredients and potential targets of Erhuang Quzhi Granules on non-alcoholic fatty liver disease based on network pharmacology."JOURNAL OF ETHNOPHARMACOLOGY.2023 Jul;311:116435 52. [IF=9.429] Su Wenting et al."An intravitreal-injectable hydrogel depot doped borneol-decorated dual-drug-coloaded microemulsions for long-lasting retina delivery and synergistic therapy of wAMD."JOURNAL OF NANOBIOTECHNOLOGY.2023 Dec;21(1):1-19 51. [IF=6.656] Chong Chen et al."Yishen-Qingli-Huoxue Formula attenuates renal fibrosis by inhibiting indoxyl sulfate via AhR/snai1 signaling."PHYTOMEDICINE.2022 Nov;:154546 50. [IF=6.78] Wanqiu Wang et al."Rhein ameliorates septic lung injury and intervenes in macrophage metabolic reprogramming in the inflammatory state by Sirtuin 1."LIFE SCIENCES.2022 Dec;310:121115 49. [IF=19.924] Liguo Jin et al."Interface Polarization Strengthened Microwave Catalysis of MoS2/FeS/Rhein for the Therapy of Bacteria-Infected Osteomyelitis."ADVANCED FUNCTIONAL MATERIALS 48. [IF=0.986] Ji-le Lan et al."Q-marker Prediction Analysis of Rhubarb in Fengyin Decoction Based on Fingerprint and Network Pharmacology:."Nat Prod Commun. 2021;16(8): 47. [IF=1.902] Ting Zhang et al."The influence of essential oils from ZhaLi NuSi Prescription on the pharmacokinetics of its non-volatile components in normal rats."Biomedical Chromatography. 2021 Oct 21 46. [IF=2.104] Jingjing Wang et al."A novel β-cyclodextrin-rhein conjugate for improving the water solubility and bioavailability of rhein."Carbohyd Res. 2020 Apr;490:107958 45. [IF=2.896] Tianming Wang et al."Quantification of prostaglandins E2 and D2 using liquid chromatography-tandem mass spectrometry in a mouse ear edema model."Anal Methods-Uk. 2020 Jun;12(22):2865-2871 44. [IF=3.361] Shen Zhuang et al."Rhein protects against barrier disruption and inhibits inflammation in intestinal epithelial cells."Int Immunopharmacol. 2019 Jun;71:321 43. [IF=3.935] Li Xie et al."Development of an UHPLC-MS/MS method for comparative pharmacokinetics of nine anthraquinones in rats and application to dosage conversion between different Semen Cassiae forms."J Pharmaceut Biomed. 2019 Sep;174:696 42. [IF=4.36] Li Lin et al."Study on the protection of water extracts of Polygoni Multiflori Radix and Polygoni Multiflori Radix Praeparata against NAFLD and its mechanism."J Ethnopharmacol. 2020 Apr;252:112577 41. [IF=4.759] Yi Zhang et al."Screening of inhibitors against histone demethylation jumonji domain-containing protein 3 by capillary electrophoresis."J Chromatogr A. 2020 Feb;1613:460625 40. [IF=4.759] Yueping Jiang et al."Application of multifold characteristic ion filtering combined with statistical analysis for comprehensive profiling of chemical constituents in anti-renal interstitial fibrosis I decoction by ultra-high performance liquid chromatogra 39. [IF=5.645] Li-Xia Dai et al."Ultrasound-assisted extraction of five anthraquinones from Rheum palmatum water extract residues and the antimicrobial activities."Ind Crop Prod. 2021 Apr;162:113288 38. [IF=9.381] Ya Zhao et al."Polysaccharide from vinegar baked radix bupleuri as efficient solubilizer for water-insoluble drugs of Chinese medicine."Carbohyd Polym. 2020 Feb;229:115473 37. [IF=2.406] Guo Lei et al."Optimized extraction process and identification of antibacterial substances from Rhubarb against aquatic pathogenic Vibrio harveyi."3 Biotech. 2017 Dec;7(6):1-9 36. [IF=3.049] Yan Dai et al."Identification of drug transporters involved in the uptake and efflux of rhein in hepatocytes."Rsc Adv. 2017 Mar;7(25):15236-15245 35. [IF=3.205] Dong-Dong Hu et al."Simultaneous determination of ten compounds in rat plasma by UPLC-MS/MS: Application in the pharmacokinetic study of Ma-Zi-Ren-Wan."J Chromatogr B. 2015 Sep;1000:136 34. [IF=3.361] Yan Cheng et al."Solubility and solution thermodynamics of rhein in eight pure solvents from (288.15 to 313.15) K."Rsc Adv. 2015 Sep;5(98):80548-80552 33. [IF=3.366] Wu Xingqiang et al."A Novel Selective Accelerated Solvent Extraction for Effective Separation and Rapid Simultaneous Determination of Six Anthraquinones in Tartary Buckwheat and Its Products by UPLC–DAD."Food Anal Method. 2015 May;8(5):1124-1132 32. [IF=3.448] Shen Zhuang et al."Rhein ameliorates lipopolysaccharide-induced intestinal barrier injury via modulation of Nrf2 and MAPKs."Life Sci. 2019 Jan;216:168 31. [IF=3.571] Shen Zhuang et al."Rhein from Rheum rhabarbarum Inhibits Hydrogen-Peroxide-Induced Oxidative Stress in Intestinal Epithelial Cells Partly through PI3K/Akt-Mediated Nrf2/HO-1 Pathways."J Agr Food Chem. 2019;67(9):2519–2529 30. [IF=3.738] Selma Houchi et al."Investigation of common chemical components and inhibitory effect on GES-type β-lactamase (GES22) in methanolic extracts of Algerian seaweeds."Microb Pathogenesis. 2019 Jan;126:56 29. Wang, Qian, et al. "Identification and pharmacokinetics of multiple constituents in rat plasma after oral administration of Yinchenzhufu decoction." Journal of ethnopharmacology 153.3 (2014): 714-724.https://doi.org/10.1016/j.jep.2014.03.039 28. Hu, Dong-Dong, et al. "Evaluation of the pharmacokinetics and renal excretion of Ma-Zi-Ren-Wan in health subjects." World Journal of Traditional Chinese Medicine 3.2 (2017): 8.DOI: 10.15806/j.issn.2311-8571.2016.0050 27. Guo, L., Guo, J. & Xu, F. Optimized extraction process and identification of antibacterial substances from Rhubarb against aquatic pathogenic Vibrio harveyi . 3 Biotech 7, 377 (2017). https://doi.org/10.1007/s13205-017-1012-2 26. Shen Zhuang, Jia Zhong, Yifei Bian, Yingsai Fan, Qiyan Chen, Ping Liu, Zhongjie Liu, Rhein ameliorates lipopolysaccharide-induced intestinal barrier injury via modulation of Nrf2 and MAPKs, Life Sciences, Volume 216, 2019, Pages 168-175, ISSN 0024-3205, ht 25. Shen Zhuang, Ruyang Yu, Jia Zhong, Ping Liu, and Zhongjie Liu,Rhein from Rheum rhabarbarum Inhibits Hydrogen-Peroxide-Induced Oxidative Stress in Intestinal Epithelial Cells Partly through PI3K/Akt-Mediated Nrf2/HO-1 Pathways, Journal of Agricultural and F 24. 王盼,储全根,轩云,蔡正银.抵当陷胸汤HPLC-MS指纹图谱研究[J].时珍国医国药,2020,31(12):2937-2940. 23. 兰济乐,阮叶萍,邱璐琦.基于BAS-GA-BP神经网络结合熵权法多指标优化风引汤提取工艺[J].中国中药杂志,2020,45(23):5686-5693. 22. 陆杰,王婷婷,梁琨,安叡,王新宏,陈颖.UPLC-LTQ-Orbitrap-MS法分析大承气汤化学成分[J].中成药,2020,42(12):3275-3280. 21. 王宇卿 李淑娇 姜旭.HPLC-ABTS-DAD-Q-TOF/MS在线检测大黄抗氧化活性成分[J].中国医院药学杂志 2019 39(11):1149-1152. 20. 李蒙蒙,田小杏,马丽娟,蒲晓辉,袁琦,宗兰兰,徐颖峰.薄层色谱法鉴别三黄片中的有效成分[J].河南大学学报(医学版),2016,35(02):81-84+109. 19. 刘全德,唐仕荣,宋慧,王营,邢洪伟.芦荟蒽醌类化合物的超声提取及其抗氧化性研究[J].食品与机械,2011,27(05):68-71. 18. 郭允, 陈永超, 李晓花,等. 牛黄解毒片中6种指标成分的含量测定[J]. 沈阳药科大学学报, 2016(6):454-458. 17. 胡江, 缪菁, 段淑芳,等. 大黄酸对2型糖尿病模型大鼠的保护作用[J]. 中国药房, 2014, 025(023):2113-2116. 16. 杨强 蒲晓辉 李晓花. 一清胶囊中7种指标成分的测定[J]. 华西药学杂志 2017(3). 15. 李晓花 郭允 李佳 袁琦 蒲晓辉 王高峰.RP-HPLC法同时测定三黄片中7种指标成分的含量[J].沈阳药科大学学报 2016 33(08):637-642. 14. 支旭然 刘洪涛 吴茵 等. UPLC-MS/MS法同时测定肾康注射液中7个有效成分[J]. 药物分析杂志 2017 037(001):37-42. 13. 支旭然, 白万军, 王祁民,等. 肾康注射液的配伍稳定性考察[J]. 中国药师, 2016, 19(011):2155-2157. 12. 蔡芳, 任繁栋, 任达兵,等. 整合定性策略用于大黄素代谢物的高通量靶向鉴定[J]. 分析化学, 2019, 047(008):1212-1218. 11. 张雯婧, 于孟飞, 刘贝贝,等. 大黄酸抑制气道平滑肌收缩机制研究[J]. 江汉大学学报(自然科学版), 2019, v.47;No.160(02):62-67. 10. 段淑芳, 胡江. 大黄酸对高糖诱导的大鼠肾脏系膜细胞的PPARγ信号通路的调控[J]. 实用医学杂志, 2018, 034(010):1636-1639. 9. 侍阳, 宋庆伟, 于生才,等. 大黄酸对肝移植大鼠急性排斥反应的影响[J]. 山东医药, 2014, 000(046):30-32. 8. 段淑芳, 胡江, 缪菁,等. 大黄酸对糖尿病大鼠肾脏系膜细胞炎症因子的调控[J]. 浙江中西医结合杂志, 2016(8期):714-716. 7. 胡江, 段淑芳, 缪菁,等. 大黄酸对糖尿病大鼠合并非酒精性脂肪性肝病的保护作用研究[J]. 浙江中医药大学学报, 2014, 38(5):521-525. 6. 段淑芳,胡江. 大黄酸对2型糖尿病大鼠胰腺的保护作用[J]. 浙江实用医学(3期):157-159. 5. 杜睿 翁朝泽 高璐璐 等. 决明子的HPLC指纹图谱及3种游离蒽醌含量的同步测定[J]. 药物生物技术 2014 021(005):445-448. 4. 李宵 吴茵 支旭然 等. UPLC-MS/MS法同时测定苦黄注射液中7种成分的含量[J]. 中国药房 2017 028(015):2108-2112. 3. 李红英 向极钎 龙澜 等. HPLC法测定大黄药材中5种游离蒽醌的含量[J]. 安徽农业科学 2013(12):5278-5279. 2. 魏艳婷 张静宜 张华潭 等. HPLC法同时测定三黄滴丸中5种蒽醌类成分的含量[J]. 中国药房 2015. 1. 支旭然 董占军 吴茵 等. HPLC同时测定肾康注射液中的4种成分[J]. 华西药学杂志 2017(03):297-299.