丹皮酚 HPLC≥98%

Paeonol

源叶
B20266
552-41-0
C9H10O3
166.17
MFCD00008730
2′-羟基-4′-甲氧基苯乙酮;芍药醇;牡丹酚
品牌 货号 产品规格 价格(RMB) 库存(上海) 北京 武汉 南京 购买数量
源叶 B20266-20mg HPLC≥98% ¥100.00元 >10 1 >10 2
产品介绍 参考文献(58篇) 质检证书(COA) 摩尔浓度计算器 相关产品

产品介绍

Paeonol 是一种从牡丹中提取的活性物质,可抑制 MAO-A 和 MAO-B,IC50 分别为 54.6 μM 和 42.5 μM。

熔点: 48-50°C(lit.)
沸点: 154 °C / 20mmHg
外观: 白色或微黄色有光泽的针状结晶,无色针状结晶(乙醇)。
溶解性: Ethanol  :  50  mg/mL  (300.90  mM;  Need  ultrasonic)

DMSO  :  ≥  38  mg/mL  (228.68  mM)

H2O  :  1  mg/mL  (6.02  mM;  Need  ultrasonic)
储存条件: 2-8℃
注意: 部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。

参考文献(58篇)

53. [IF=4.8] Yao Zhang et al."Paeonol and glycyrrhizic acid in combination ameliorate the recurrent nitroglycerin-induced migraine-like phenotype in rats by regulating the GABBR2/TRPM8/PRKACA/TRPV1 pathway."JOURNAL OF ETHNOPHARMACOLOGY.2024 Jun;:118464 52. [IF=3.8] Deng Bo et al."Paeonol attenuated high glucose-induced apoptosis via up-regulating miR-223-3p in mouse cardiac microvascular endothelial cells."Scientific Reports.2024 Jul;14(1):1-8 51. [IF=6.5] Ziwei Wang et al."Combined metabolomics and bioactivity assays kernelby-productsof two native Chinese cherry species: The sources of bioactive nutraceutical compounds."Food Chemistry-X.2024 Oct;23:101625 50. [IF=2.5] Jing Liu et al."Phytochemical Identification and Anti-Oxidative Stress Effects Study of Cimicifugae Rhizoma Extract and Its Major Component Isoferulic Acid."Separations.2024 Jun;11(6):175 49. [IF=5.4] Guiming Yan et al."Paeonol attenuates nonalcoholic steatohepatitis by regulating intestinal flora and AhR/NLRP3/Caspase-1 metabolic pathway."JOURNAL OF ETHNOPHARMACOLOGY".2024 Apr;:118147 48. [IF=3.4] Yuerong Qian et al."Development of a novel human stratum corneum mimetic phospholipid ­vesicle-based permeation assay models for in vitro permeation studies."DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY.10.1080/03639045.2024.2331242 47. [IF=3.4] Yanhua Jiang et al."Network pharmacology combined with lipidomics to reveal the regulatory effects and mechanisms of Kangzao granules in the hypothalamus of rats with central precocious puberty."JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS".2024 May; 46. [IF=7.9] Meng Zhao et al."Paeonol alleviates ulcerative colitis in mice by increasing short-chain fatty acids derived from Clostridium butyricum."PHYTOMEDICINE.10.1016/j.phymed.2023.155056 45. [IF=1.8] Yue Qian et al."Si Miao San relieves hyperuricemia by regulating intestinal flora."BIOMEDICAL CHROMATOGRAPHY.2023 Dec;:e5807 44. [IF=5.4] Mingxiang Xie et al."Molecular mechanism of PSORI-CM01 for psoriasis by regulating the inflammatory cytokines network."JOURNAL OF ETHNOPHARMACOLOGY.2024 Jan;318:116935 43. [IF=8.1] Ziwei Wang et al."Comparative antioxidant activity and untargeted metabolomic analyses of cherry extracts of two Chinese cherry species based on UPLC-QTOF/MS and machine learning algorithms."FOOD RESEARCH INTERNATIONAL.2023 Sep;171:113059 42. [IF=2.464] Hao Mingxuan et al."Paeonol Inhibits Glioma Growth In Vivo and In Vitro by Inducing Apoptosis and Cell Cycle Arrest."Revista Brasileira de Farmacognosia-Brazilian Journal of Pharmacognosy.2023 Mar;:1-9 41. [IF=3.246] Yue Qian et al."A Network Pharmacology Method Combined with Molecular Docking Verification to Explore the Therapeutic Mechanisms Underlying Simiao Pill Herbal Medicine against Hyperuricemia."Biomed Research International.2023;2023:2507683 40. [IF=6.449] Xiaoxiao Wang et al."Physicochemical analysis, sensorial evaluation, astringent component identification and aroma-active compounds of herbaceous Peony (Paeonia lactiflora Pall) black tea."INDUSTRIAL CROPS AND PRODUCTS.2023 Mar;193:116159 39. [IF=3.385] Yaxue Li et al."The effect of dietary paeonol on growth performance, antioxidant enzyme activities and gene expressions of Genetic Improvement of Farmed Tilapia juveniles (Oreochromis niloticus)."Aquaculture Reports.2022 Oct;26:101302 38. [IF=4.996] Yuan Jie et al."Systematic characterization of the components and molecular mechanisms of Jinshui Huanxian granules using UPLC-Orbitrap Fusion MS integrated with network pharmacology."Scientific Reports.2022 Jul;12(1):1-24 37. [IF=5.135] Lijuan Yu et al."Acetylferulic paeonol ester: A new feed additive reduces lipid accumulation in the liver of Nile tilapia (Oreochromis niloticus) by modulating lipid and glucose metabolism."AQUACULTURE.2022 Dec;561:738671 36. [IF=2.952] Shouzhu Xu et al."Paeonol alleviates lipopolysaccharide‑induced hepatocytes injury through alteration of mitochondrial function and NF‑κB translocation."Mol Med Rep. 2021 Nov;24(5):1-9 35. [IF=3] Qu Lala et al."Phenotypic assessment and ligand screening of ETA/ETB receptors with label-free dynamic mass redistribution assay."N-S Arch Pharmacol. 2020 Jun;393(6):937-950 34. [IF=3.512] Yahong Chen et al."Identification of Potential Human Ryanodine Receptor 1 Agonists and Molecular Mechanisms of Natural Small-Molecule Phenols as Anxiolytics."Acs Omega. 2021;XXXX(XXX):XXX-XXX 33. [IF=3.69] Qianni Duan et al."Antiviral effect of Chinese herbal prescription JieZe-1 on adhesion and penetration of VK2/E6E7 with herpes simplex viruses type 2."J Ethnopharmacol. 2020 Mar;249:112405 32. [IF=3.935] Zhengchao Ji et al."Global identification and quantitative analysis of representative components of Xin-Nao-Kang Capsule, a traditional Chinese medicinal formula, by UHPLC-Q-TOF-MS and UHPLC-TQ-MS."J Pharmaceut Biomed. 2021 May;198:114002 31. [IF=3.996] Liu Dong-Hai et al."Anticonvulsant and Neuroprotective Effects of Paeonol in Epileptic Rats."Neurochem Res. 2019 Nov;44(11):2556-2565 30. [IF=3.998] Mei Liyan et al."Paeonol attenuates inflammation by targeting HMGB1 through upregulating miR-339-5p."Sci Rep-Uk. 2019 Dec;9(1):1-15 29. [IF=4.36] Xiaoli Zhao et al."Transcriptomic study of the mechanism by which the Kai Yu Zhong Yu recipe improves oocyte quality in a stressed mouse model."J Ethnopharmacol. 2021 Oct;278:114298 28. [IF=4.53] Du Jikun et al."Paeonol triggers apoptosis in HeLa cervical cancer cells: the role of mitochondria-related caspase pathway."Psychopharmacology. 2021 Mar 12 27. [IF=5.875] Fangyuan Wang et al."Paeonol-loaded PLGA nanoparticles as an oral drug delivery system: Design, optimization and evaluation."Int J Pharmaceut. 2021 Jun;602:120617 26. [IF=6.165] Jinpeng Liu et al."Temperature-sensitive lyotropic liquid crystals as systems for transdermal drug delivery."J Mol Liq. 2021 Mar;326:115310 25. [IF=7.514] Lijuan Yu et al."Synthesis and evaluation of acetylferulic paeonol ester and ferulic paeonol ester as potential antioxidants to inhibit fish oil oxidation."Food Chem. 2021 Dec;365:130384 24. [IF=3.361] Xia Liu et al."Paeonol attenuates acute lung injury by inhibiting HMGB1 in lipopolysaccharide-induced shock rats."Int Immunopharmacol. 2018 Aug;61:169 23. [IF=5.076] Huichao Xie et al."An Available Strategy for Nasal Brain Transport of Nanocomposite Based on PAMAM Dendrimers via In Situ Gel."Nanomaterials-Basel. 2019 Feb;9(2):147 22. [IF=6.529] Xing-Yan Liu et al."The activity of Hou-Po-Da-Huang-Tang is improved through intestinal bacterial metabolism and Hou-Po-Da-Huang-Tang selectively stimulate the growth of intestinal bacteria associated with health."Biomed Pharmacother. 2017 Oct;94:794 21. Duan, Qianni, et al. "Antiviral effect of Chinese herbal prescription JieZe-1 on adhesion and penetration of VK2/E6E7 with herpes simplex viruses type 2." Journal of ethnopharmacology 249 (2020): 112405.https://doi.org/10.1016/j.jep.2019.112405 20. Xie H, Li L, Sun Y, Wang Y, Gao S, Tian Y, Ma X, Guo C, Bo F, Zhang L. An Available Strategy for Nasal Brain Transport of Nanocomposite Based on PAMAM Dendrimers via In Situ Gel. Nanomaterials. 2019; 9(2):147. https://doi.org/10.3390/nano9020147 19. Liu, Dong-Hai, et al. "Anticonvulsant and neuroprotective effects of paeonol in epileptic rats." Neurochemical research 44.11 (2019): 2556-2565. 18. 段昆,高霞,耿婷,陈夏霖,曹亮,肖伟,王振中.基于血清代谢组学技术探讨桂枝茯苓胶囊及其主要成分治疗原发性痛经的作用机制[J].中国新药杂志,2020,29(18):2066-2074. 17. 赵秋龙,卞晓坤,钱大玮,宿树兰,郭盛,王团结,段金廒.桂枝茯苓胶囊在原发性痛经模型大鼠血浆、胆汁、尿液和粪便中的代谢产物研究[J].药物分析杂志,2021,41(01):51-63. 16. 代天,杨萍,刘波,张苏川.芍药醇调控miR-122-5p/GSTM1分子轴对缺血再灌注心肌细胞存活的影响[J].中国药师,2021,24(02):232-236. 15. 代天,杨萍,刘波,张苏川.芍药醇调控miR-122-5p/GSTM1分子轴对缺血再灌注心肌细胞存活的影响[J].中国药师,2021,24(02):232-236. 14. 牛琴,钮红丽,翟俊英,王韵一,马志宾,王莉.丹皮酚通过内质网应激和线粒体损伤途径促进卵巢癌细胞凋亡[J].广州中医药大学学报,2020,37(10):1991-1998. 13. 程江雪, 唐志书, 郭东艳, et al. 不同配伍配比对赤芍-当归药对中10个成分溶出量的影响研究[J]. 药物分析杂志, 2019, v.39(09):73-80. 12. 付士朋, 沈宏伟, 王谦博,等. 赤芍饮片加工工艺的优化[J]. 中成药, 2019(8). 11. 王化, 何丹娆, 朱良玉,等. HPLC法同时测定赤芍中9个活性成分的含量[J]. 中草药, 2018, 049(003):708-711. 10. 王秀秀, 李智慧, 石森林,等. 桂枝茯苓浓缩丸多指标成分体外溶出度研究[J]. 中华中医药学刊, 2014, 032(012):2875-2877. 9. 吴素香, 石森林, 葛卫红,等. 桂枝茯苓丸有效成分与物质组的溶出相关性[J]. 中成药, 2016, 38(11):2360-2365. 8. 刘灵改, 支旭然, 吴宗耀,等. 高效液相色谱法测定防芷鼻咽颗粒中7种活性成分的含量[J]. 中国药学杂志, 2014, 49(017):1554-1558. 7. 刘灵改 支旭然 郭进 等. HPLC-MS法同时测定防芷鼻咽颗粒中6个成分的含量[J]. 药物分析杂志 2014(5):830-835. 6. 段昆, 高霞, 耿婷, et al. 桂枝茯苓胶囊及其主要成分对原发性痛经模型大鼠肠道菌群的影响[J]. 中国药房, 2020, v.31;No.677(11):45-51. 5. 张佳欢 李智慧 石森林 等. 不同剂型桂枝茯苓丸的溶出度比较[J]. 浙江中医杂志 2019 v.54;No.582(09):73-74. 4. 赵婷秀 曹迪 茆文莉 等. HPLC-QTOF-MS分析六味地黄丸不同部位的化学成分[J]. 中药新药与临床药理 2018 029(004):489-496. 3. 孙晶, 魏永利, 李克明,等. 高效液相色谱法测定6个不同产地的牡丹叶中丹皮酚和芍药苷含量[J]. 山东科学, 2020, 000(001):24-28. 2. 向极钎, 杨永康, 龙澜,等. 湖北建始丹皮HPLC指纹图谱研究[J]. 湖北农业科学, 2013(22):5521-5524. 1. 张乔 俞洋洋 王勤辉 等. 六味地黄制剂多类型成分快速分析和"一测多评"方法建立[J]. 中国实验方剂学杂志 2014 020(006):81-86.

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