• 介绍：

  Piperine是从胡椒中分离的天然生物碱，可以抑制P-glycoprotein and CYP3A4的活性，在HeLa细胞中的IC50值为61.94±0.054 μg/mL。

• 熔点： 131-135°C(lit.)

• 沸点： 498.524°C at 760 mmHg

• 外观： 白色晶体粉末

• 溶解性： DMSO  :  50  mg/mL  (175.23  mM;  Need  ultrasonic)

• 敏感性： 对光,湿度,空气敏感

• 储存条件： 2-8℃

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

• 17. [IF=8.2] Kangyun Zhao et al."Investigation of the formation mechanism of the pepper starch-piperine complex."INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES".2024 May;268:131777

• 16. [IF=5.8] Chang Yang et al."Umbilical therapy for promoting transdermal delivery of topical formulations: Enhanced effect and underlying mechanism."INTERNATIONAL JOURNAL OF PHARMACEUTICS.2024 Mar;652:123834

• 15. [6.51] Jiawei Han et al."Mechanistic insight into gel formation of co-amorphous resveratrol and piperine during dissolution process."INTERNATIONAL JOURNAL OF PHARMACEUTICS.2023 Mar;634:122644

• 14. [IF=3.756] Jiawei Han et al."Self-gelation involved in the transformation of resveratrol and piperine from a co-amorphous system into a co-crystal system."CRYSTENGCOMM.2022 Jul;:

• 13. [IF=7.419] Baoyi Chen et al."Protective effect of oxyberberine against acute lung injury in mice via inhibiting RhoA/ROCK signaling pathway."BIOMEDICINE & PHARMACOTHERAPY.2022 Sep;153:113307

• 12. [IF=6.321] Yanjie Liu et al."Crystal Structure, Solubility, and Pharmacokinetic Study on a Hesperetin Cocrystal with Piperine as Coformer."Pharmaceutics. 2022 Jan;14(1):94

• 11. [IF=3.779] Xingming Hou et al."Natural Piperine Improves Lipid Metabolic Profile of High-Fat Diet-Fed Mice by Upregulating SR-B1 and ABCG8 Transporters."J Nat Prod. 2021;84(2):373–381

• 10. [IF=6.023] Maiquan Li et al."Discovery of Keap1−Nrf2 small−molecule inhibitors from phytochemicals based on molecular docking."Food Chem Toxicol. 2019 Nov;133:110758

• 9. [IF=2.419] Tingting Gao et al."Characterization of piperine metabolites in rats by ultra-high-performance liquid chromatography with electrospray ionization quadruple time-of-flight tandem mass spectrometry."Rapid Commun Mass Sp. 2017 Jun;31(11):901-910

• 8. [IF=3.046] Liwei Dong et al."Echinacoside induces apoptotic cancer cell death by inhibiting the nucleotide pool sanitizing enzyme MTH1."Oncotargets Ther. 2015; 8: 3649–3664

• 7. [IF=5.875] Ruoning Wang et al."Involvement of metabolism-permeability in enhancing the oral bioavailability of curcumin in excipient-free solid dispersions co-formed with piperine."Int J Pharmaceut. 2019 Apr;561:9

• 6. Gao, Tingting, et al. "Characterization of piperine metabolites in rats by ultra‐high‐performance liquid chromatography with electrospray ionization quadruple time‐of‐flight tandem mass spectrometry." Rapid Communications in Mass Spectrometry 31.11 (2017):

• 5. 陆昕怡, 韩加伟, 李文,等. 姜黄素/胡椒碱固体分散体的制备及体外评价[J]. 现代中药研究与实践, 2018, 032(003):49-53.

• 4. 黄容, 陆昕怡, 韩加伟,等. 姜黄素-胡椒碱固体分散体的制备与生物利用度研究. 中草药.

• 3. 陈永昆, 姜亭亭, 吉世松,等. 胡椒碱联合硝苯地平对家兔血压的影响[J]. 临床医学研究与实践, 2017, 2(033):10-11.

• 2. 宋思维, 唐艳红. 胡椒碱对缺氧复氧心肌细胞的保护作用及机制研究[J]. 岭南心血管病杂志, 2019, 25(01):113-118.

• 1. 严玉玲, 郭焰, 豆一玲. 胡椒碱分离纯化工艺的研究[J]. 中国农业信息, 2015(17):165.

输入产品批号：

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *