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B20707	雷公藤红素
源叶	分析标准品,HPLC≥98%

英文名：
Celastrol

别名：

CAS号：
34157-83-0

分子式：
C₂₉H₃₈O₄

分子量：
450.61

MDL：
MFCD03424073

核磁/质谱：

品牌	货号	产品规格	价格(RMB)	库存（上海）	北京	武汉	南京	数量	计量单位	加入购物车...
源叶	B20707-20mg	分析标准品,HPLC≥98%	￥400.00元	>10	1	1	4		EA	加入购物车
源叶	B20707-200mg	分析标准品,HPLC≥98%	￥2400.00元	>10	-	-	-		EA	加入购物车

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产品介绍

参考文献(26篇)

质检证书(COA)

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介绍：
Tripterin (Celastrol) 是一种蛋白酶体抑制剂，有效且优先抑制20S 蛋白酶体的胰凝乳蛋白酶样活性，IC50 为2.5 μM。

熔点： 185-200°C

沸点： 645.7 °C at 760 mmHg

外观：红色粉末

溶解性： DMSO : 33.33 mg/mL (73.97 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)

储存条件： -20℃

注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

26. [3.8] Xiu-mei Luan et al."Improvement of polarity-based solvent system for countercurrent chromatography in the guidance of solvent selectivity: n-hexane/ethyl acetate/ alcohol solvents/water as an example."JOURNAL OF CHROMATOGRAPHY A.2024 Nov;1736:465389

25. [13.3] Jiahang Tian et al."Mechanism of Self-Assembled Celastrol-Erianin Nanomedicine for treatment of breast cancer."CHEMICAL ENGINEERING JOURNAL.2024 Sep;:155709

24. [3.3] Kang Wu et al."The anti-cancer mechanism of Celastrol by targeting JAK2/STAT3 signaling pathway in gastric and ovarian cancer."TOXICOLOGY AND APPLIED PHARMACOLOGY.2024 Aug;:117077

23. [IF=10.2] Piao Luo et al."Mechanistic engineering of celastrol liposomes induces ferroptosis and apoptosis by directly targeting VDAC2 in hepatocellular carcinoma."Asian Journal of Pharmaceutical Sciences.2023 Nov;18:100874

22. [IF=3.3] Wan Lei et al."A novel pharmaceutical preparation of Tripterygium wilfordii Hook. f. regulates macrophage polarization to alleviate inflammation in rheumatoid arthritis."JOURNAL OF PHARMACY AND PHARMACOLOGY.10.1093/jpp/rgad078

21. [IF=3] Ling Ye et al."Celastrol attenuates HFD-induced obesity and improves metabolic function independent of adiponectin signaling."ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY.

20. [IF=11.092] Hongwen Liu et al."Copper Increases the Sensitivity of Cholangiocarcinoma Cells to Tripterine by Inhibiting TMX2-Mediated Unfolded Protein Reaction Activation."Advanced Healthcare Materials.2023 Apr;:2300913

19. [IF=6.533] Liying Guo et al."Celastrol attenuates 6-hydroxydopamine-induced neurotoxicity by regulating the miR-146a/PI3K/Akt/mTOR signaling pathways in differentiated rat pheochromocytoma cells."JOURNAL OF AFFECTIVE DISORDERS.2022 Nov;316:233

18. [IF=6.656] Si-wei Wang et al."Celastrol inhibits TXNIP expression to protect pancreatic β cells in diabetic mice."PHYTOMEDICINE.2022 Sep;104:154316

17. [IF=3.981] Qian Kang et al."Application of quality by design approach to formulate and optimize tripterine loaded in nanostructured lipid carriers for transdermal delivery."J Drug Deliv Sci Tec. 2019 Aug;52:1032

16. [IF=6.4] Jinran Li et al."Celastrol Self-Stabilized Nanoparticles for Effective Treatment of Melanoma."Int J Nanomed. 2020; 15: 1205–1214

15. [IF=6.953] Yun Qian et al."Nanoparticles based on polymers modified with pH-sensitive molecular switch and low molecular weight heparin carrying Celastrol and ferrocene for breast cancer treatment."Int J Biol Macromol. 2021 Jul;183:2215

14. Sun, J, Wang, H-J, Yu, J, Li, T, Han, Y. Protective effect of celastrol on type 2 diabetes mellitus with nonalcoholic fatty liver disease in mice. Food Sci Nutr. 2020; 8: 6207– 6216. https://doi.org/10.1002/fsn3.1917

13. Kang, Qian, et al. "Application of quality by design approach to formulate and optimize tripterine loaded in nanostructured lipid carriers for transdermal delivery." Journal of Drug Delivery Science and Technology 52 (2019): 1032-1041.https://doi.org/10.10

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8. 胡绍英, 张振海, 蒋艳荣, et al. 雷公藤红素胶体二氧化硅缓释固体分散体研究[J]. 中草药, 2013(6):692-695.

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6. 夏海建, 2], 张振海,等. 雷公藤红素环糊精与油自组装小珠载药系统的制备及其体外评价[J]. 中草药, 2013, 44(019):2672-2676.

5. 吴章, 吕望, 陈新国,等. 雷公藤红素对高糖诱导的H9C2细胞损伤的保护作用[J]. 温州医科大学学报, 2020(1):24-29.

4. 徐佳, 伍春莲, 彭聪,等. 雷公藤红素对人肺癌细胞增殖与凋亡的影响[J]. 西华师范大学学报(自然科学版), 2014(1):51-56.

3. 王黎,秦桂芳,柯鸿,魏广民.雷公藤红素对人急性早幼粒细胞白血病SCID小鼠移植瘤模型凝血功能的影响[J].中国中医急症,2019,28(02):232-235.

2. 陈小云, 张振海, 胡绍英,等. 基于硬脂酸改性纳米碳酸钙的雷公藤红素缓释固体分散体的研究[J]. 中国药学杂志, 2013, 48(16):1380-1384.

1. 胡绍英, 张振海, 蒋艳荣,等. 基于HPMC-硬脂酸的雷公藤红素缓释固体分散体的研究[J]. 中国中药杂志, 2012, 37(020):3052-3055.