58. [IF=6.8] Feiyan Chen et al."Identification of AIF1 as a protein target of notoginsenosides in brain tissue of mice with intracerebral hemorrhage based on hapten immunoaffinity fishing technique."Journal of Ginseng Research.2025 Apr;: 57. [IF=3.8] Chen Yue et al."Impact of ginsenoside Rb1 on gut microbiome and associated changes in pharmacokinetics in rats."Scientific Reports.2024 Sep;14(1):1-12 56. [IF=3.8] Yuan Liang et al."Ginsenoside CK ameliorates tumor growth in lung cancer mice via inhibiting EGFR."Journal of Functional Foods.2024 Oct;121:106446 55. [IF=1.3] Hong-Ping Wang et al."Screening of GLP-1r agonists from natural products using affinity ultrafiltration screening coupled with UPLC-ESI-Orbitrap-MS technology: a case study of Panax ginseng."JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH. 54. [IF=3.5] Hong Yinan et al."Biotransformation of ginsenoside compound K using β-glucosidase in deep eutectic solvents."BIOPROCESS AND BIOSYSTEMS ENGINEERING.2024 Jun;:1-11 53. [IF=3.9] Chen Jiaxin et al."Ginsenoside compound K induces ferroptosis via the FOXO pathway in liver cancer cells."BMC Complementary Medicine and Therapies".2024 Dec;24(1):1-13 52. [IF=5.2] Yanbo Hu et al."Targeted preparation of six rare ginsenosides using two β-glucosidases from Bifidobacterium adolescentis."Food Bioscience".2024 Jun;59:104192 51. [IF=2.7] Wenjie Su et al."Therapeutic effect of notoginseng saponins before and after fermentation on blood deficiency rats."Experimental and Therapeutic Medicine".2024 Apr;27(4):1-16 50. [IF=5] Xiaoyan You et al."Multifunctional Liposomes Co-Modified with Ginsenoside Compound K and Hyaluronic Acid for Tumor-Targeted Therapy."Polymers".2024 Jan;16(3):405 49. [IF=0.7] Yang Bai et al."Ginsenoside CK Induces the Mitochondrial Apoptosis in Glioma Cells Through the Activation of the p53-Bax-Caspase Pathway."Pharmacognosy Magazine.;(): 48. [IF=1.6] Dai Tingting et al."Prediction of molecular mechanism of processed ginseng in the treatment of heart failure based on network pharmacology and molecular docking technology."MEDICINE.2023 Dec;102(49):e36576 47. [IF=5.8] Ziwei Li et al."Oral liposomes encapsulating ginsenoside compound K for rheumatoid arthritis therapy."INTERNATIONAL JOURNAL OF PHARMACEUTICS.2023 Jul;:123247 46. [IF=7.2] Jinfen Chen et al."20(S)- Protopanaxadiol saponins isolated from Panax notoginseng target the binding of HMGB1 to TLR4 against inflammation in experimental ulcerative colitis."PHYTOTHERAPY RESEARCH.2023 Jul;: 45. [IF=3.2] Yuqing Xu et al."Optimization of Rare Ginsenosides and Antioxidant Activity Quality of Ginseng Jiaosu Based on Probiotic Strains and Fermentation Technology."JOURNAL OF FOOD QUALITY.2023;2023:5686929 44. [IF=5.735] Feiyan Chen et al."Discovery and validation of PURA as a transcription target of 20(S)-protopanaxadiol: Implications for the treatment of cognitive dysfunction."Journal of Ginseng Research.2023 Apr;: 43. [IF=5.223] Xiao-Li Li et al."Effect of ginsenoside CK combined with cisplatin on the proliferation and migration of human cervical cancer HeLa cells via Ras/ERK/MAPK pathway."Journal of Functional Foods.2023 Mar;102:105438 42. [IF=6.751] Xiaodi Niu et al."Antifungal activity of ginsenoside CK against Botrytis cinerea by targeting sterol 14α-demethylase cytochrome P450 (CYP51) and the application on cherry tomato preservation."POSTHARVEST BIOLOGY AND TECHNOLOGY.2023 May;199:112294 41. [IF=3.776] Yuzhu Hou et al."Anti-cancer effects of ginsenoside CK on acute myeloid leukemia in vitro and in vivo."Heliyon.2022 Dec;8:e12106 40. [IF=4.927] Qinhua Zheng et al."Protective Effect of Flavonoids from Mulberry Leaf on AAPH-Induced Oxidative Damage in Sheep Erythrocytes."MOLECULES.2022 Jan;27(21):7625 39. [IF=3.268] Jiaxin Chen et al."Ginsenoside compound K induces mitochondrial apoptosis in human hepatoma cells through Bclaf1-mediated modulation of ERK signaling."FOOD AND AGRICULTURAL IMMUNOLOGY 38. [IF=5.168] Pan Wang et al."Discovery and characterization of novel ATP citrate lyase inhibitors from natural products by a luminescence-based assay."CHEMICO-BIOLOGICAL INTERACTIONS.2022 Nov;367:110199 37. [IF=6.055] Baoyu Fu et al."Ginsenosides improve reproductive capability of aged female Drosophila through mechanism dependent on ecdysteroid receptor (ECR) and steroid signaling pathway."Frontiers in Endocrinology.2022; 13: 964069 36. [IF=2.419] Yinping Jin et al."Dynamic changes of ginsenosides in Panax quinquefolius fruit at different development stages measured by UHPLC-Orbitrap MS."Rapid Communications In Mass Spectrometry. 2022 Feb 17 35. [IF=4.432] Shuai Zhang et al."Ginsenoside Rf inhibits human tau proteotoxicity and causes specific LncRNA, miRNA and mRNA expression changes in Caenorhabditis elegans model of tauopathy."Eur J Pharmacol. 2022 May;922:174887 34. [IF=1.632] Wu Song et al."Ginsenoside compound K inhibits oxidative stress and NLRP3 inflammasome activity in mice exposed to chronic unpredictable mild stress."Biotechnol Biotec Eq. 2019;33(1):1372-1379 33. [IF=2.055] Qian Chen et al."Shenyan Kangfu tablet alleviates diabetic kidney disease through attenuating inflammation and modulating the gut microbiota."J Nat Med-Tokyo. 2021 Jan;75(1):84-98 32. [IF=2.629] Zhang Meiyu et al."In Vitro Transformation of Protopanaxadiol Saponins in Human Intestinal Flora and Its Effect on Intestinal Flora."Evid-Based Compl Alt. 2021;2021:1735803 31. [IF=3.21] Ma Zhu et al."Transformation of ginsenoside via deep eutectic solvents based on choline chloride as an enzymatic reaction medium."Bioproc Biosyst Eng. 2020 Jul;43(7):1195-1208 30. [IF=3.978] Weina Li et al."Ginsenoside CK production by commercial snailase immobilized onto carboxylated chitosan-coated magnetic nanoparticles."Biochem Eng J. 2021 Oct;174:108119 29. [IF=5.396] Hui Wang et al."Ginsenoside extract from ginseng extends lifespan and health span in Caenorhabditis elegans."Food Funct. 2021 Aug;12(15):6793-6808 28. [IF=6.023] Chenfei Li et al."Elucidation of interaction between serum albumin and ginsenoside CK along with cytotoxic study."Food Chem Toxicol. 2021 Sep;155:112403 27. [IF=9.642] Xin Han et al."Biocatalytic production of compound K in a deep eutectic solvent based on choline chloride using a substrate fed-batch strategy."Bioresource Technol. 2020 Jun;305:123039 26. [IF=3.06] Xuan Zhang et al."Compound K Induces Endoplasmic Reticulum Stress and Apoptosis in Human Liver Cancer Cells by Regulating STAT3."Molecules. 2018 Jun;23(6):1482 25. [IF=3.935] Shan-Shan Zhou et al."Synchronous characterization of carbohydrates and ginsenosides yields deeper insights into the processing chemistry of ginseng."J Pharmaceut Biomed. 2017 Oct;145:59 24. [IF=3.935] Hong Zhang et al."A multidimensional analytical approach based on time-decoupled online comprehensive two-dimensional liquid chromatography coupled with ion mobility quadrupole time-of-flight mass spectrometry for the analysis of ginsenosides from white a 23. [IF=3.935] Hong-Mei Zhang et al."Holistic quality evaluation of commercial white and red ginseng using a UPLC-QTOF-MS/MS-based metabolomics approach."J Pharmaceut Biomed. 2012 Mar;62:258 22. [IF=4.36] Bin Ma et al."Sulfur fumigation reducing systemic exposure of ginsenosides and weakening immunomodulatory activity of ginseng."J Ethnopharmacol. 2017 Jan;195:222 21. [IF=4.952] Jiali Chen et al."Ginsenosides and amino acids in flavored ginseng chips as affected by food formulation and processing technology."Lwt Food Sci Technol. 2015 Jun;62:517 20. [IF=5.34] Shan-Shan Zhou et al."Stronger anti-obesity effect of white ginseng over red ginseng and the potential mechanisms involving chemically structural/compositional specificity to gut microbiota."Phytomedicine. 2020 Aug;74:152761 19. [IF=6.06] Jiahong Han et al."Compatibility effects of ginseng and Ligustrum lucidum Ait herb pair on hematopoietic recovery in mice with cyclophosphamide-induced myelosuppression and its material basis."J Ginseng Res. 2020 Mar;44:291 18. Joo, Kyung-Mi, et al. "Pharmacokinetic study of ginsenoside Re with pure ginsenoside Re and ginseng berry extracts in mouse using ultra performance liquid chromatography/mass spectrometric method." Journal of pharmaceutical and biomedical analysis 51.1 (20 17. Hong Zhang, Jia-Ming Jiang, Dan Zheng, Ming Yuan, Zhi-Ying Wang, Hong-Mei Zhang, Chang-Wu Zheng, Lian-Bo Xiao, Hong-Xi Xu, A multidimensional analytical approach based on time-decoupled online comprehensive two-dimensional liquid chromatography coupled wit 16. Hong Zhang, Jia-Ming Jiang, Dan Zheng, Ming Yuan, Zhi-Ying Wang, Hong-Mei Zhang, Chang-Wu Zheng, Lian-Bo Xiao, Hong-Xi Xu, A multidimensional analytical approach based on time-decoupled online comprehensive two-dimensional liquid chromatography coupled wit 15. Hong Zhang, Jia-Ming Jiang, Dan Zheng, Ming Yuan, Zhi-Ying Wang, Hong-Mei Zhang, Chang-Wu Zheng, Lian-Bo Xiao, Hong-Xi Xu, A multidimensional analytical approach based on time-decoupled online comprehensive two-dimensional liquid chromatography coupled wit 14. Han, Xin, et al. "Biocatalytic production of compound K in a deep eutectic solvent based on choline chloride using a substrate fed-batch strategy." Bioresource technology 305 (2020): 123039.https://doi.org/10.1016/j.biortech.2020.123039 13. Zhang, Xuan, et al. "Compound K induces endoplasmic reticulum stress and apoptosis in human liver cancer cells by regulating STAT3." Molecules 23.6 (2018): 1482.https://doi.org/10.3390/molecules23061482 12. 赵彩秀,王楠,黄鑫,越皓,郭云龙,刘淑莹.枯草芽孢杆菌JLGA-SD-28转化人参皂苷Rb1的特性及其全基因组测序分析[J].中成药,2021,43(02):518-523. 11. 陈佳欣,闫岩,张学武,张洪江.人参皂苷Compound K通过调控AKT/mTOR通路诱导人肝癌细胞自噬作用的研究[J].时珍国医国药,2020,31(06):1347-1350. 10. 陈佳欣,闫岩,苏杰琳,赵嘉琪,张学武.人参皂苷Compound K通过Bcl-2相关转录因子1诱导人肝癌细胞SMMC-7721自噬的作用[J].延边大学医学学报,2020,43(03):157-161. 9. 夏晚霞, 张尚微, 葛亚中,等. 乳酸菌发酵转化人参皂苷[J]. 现代食品科技, 2018, 34(09):136-142. 8. 李雪晴, 李丽, 刘秀峰,等. 三七皂苷的人肠道菌群体外代谢研究[J]. 药物生物技术, 2017(03):34-39. 7. 韩铭鑫, 李方彤, 张琰,等. 稀有原人参二醇型皂苷的人肠道菌群生物转化[J]. 高等学校化学学报, 2019, 40(7). 6. 钟雅婷 茅仁刚 宋纯清 等. RP-HPLC同时测定西洋参总皂苷转化产物中人参皂苷Rg1 Rh1 Rd Rg3和C-K的含量[J]. 江西中医药 2012 43(8):61-64. 5. 方磊,陈红,余晓斌.高转化人参皂苷菌株筛选鉴定及发酵培养基优化[J].食品与发酵工业,2017,43(04):147-151. 4. 杨伟 滕林 丁家望 等. 人参皂苷compound K对小鼠心肌梗死后心室重构的保护及免疫机制研究[J]. 心肺血管病杂志 2016 35(006):478-481. 3. 魏群 张璇 张学武.人参皂苷CK诱导人肝癌SMMC-7721细胞凋亡的内质网应激作用机制[J].时珍国医国药 2018 29(12):2896-2899. 2. 孟雪 邱智东 王蕾 等. 人参皂苷CK抑制人结肠癌SW480细胞增殖的机制研究[J]. 中草药 2020(6). 1. 陈佳欣 闫岩 张学武 等. 人参皂苷CK抑制STAT3诱导人肝癌细胞凋亡的内质网应激作用机制的研究[J]. 时珍国医国药 2020年31卷4期 796-799页 PKU CSCD CA 2020.