42. [IF=0] Danmeng Bai et al."Rapid formed temperature-sensitive hydrogel for the multi-effective wound healing of deep second-degree burn with shikonin based scar prevention."Biomaterials Advances".2024 Jun;160:213851 41. [IF=6] Yangli Wan et al."Anti Staphylococcus aureus activity of shikonin @ chitosan nanoemulsion and its effect on the storage quality of pork."FOOD CONTROL.2024 Apr;158:110203 40. [IF=4.4] Hongwei Han et al."Novel shikonin derivative suppresses tumor growth and metastasis intervention of Wnt/β-catenin pathway."PROCESS BIOCHEMISTRY.2023 Sep;132:297 39. [IF=4.5] Xudong Zhou et al."Degradation pathways and mechanisms insight of indigo and shikonin with experiments and quantum chemical calculations."DYES AND PIGMENTS.2023 Oct;218:111455 38. [IF=8.025] Sicheng Liang et al."A comparative investigation of catalytic mechanism and domain between catechol-O-methyltransferase isoforms by isomeric shikonin and alkannin."INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES.2023 May;:124758 37. [IF=4.927] Cheng-Zhu Wu et al."Isobavachalcone Induces Multiple Cell Death in Human Triple-Negative Breast Cancer MDA-MB-231 Cells."MOLECULES.2022 Jan;27(20):6787 36. [IF=5.714] Hongyan Lin et al."Natural shikonin and acetyl-shikonin improve intestinal microbial and protein composition to alleviate colitis-associated colorectal cancer."INTERNATIONAL IMMUNOPHARMACOLOGY.2022 Oct;111:109097 35. [IF=2.267] Na Zhao et al."Rapid Qualitative and Quantitative Characterization of Arnebiae Radix by Near-Infrared Spectroscopy (NIRS) with Partial Least Squares—Discriminant Analysis (PLS-DA)."ANALYTICAL LETTERS 34. [IF=5.811] 33. [IF=4.35] Yangli Wan et al."Control of Foodborne Staphylococcus aureus by Shikonin, a Natural Extract."Foods. 2021 Dec;10(12):2954 32. [IF=3.981] Luhua Meng et al."Hyaluronic acid-coated shikonin liposomes for the treatment of triple-negative breast cancer via targeting tumor cells and amplification of oxidative stress."J Drug Deliv Sci Tec. 2022 Apr;70:103193 31. [IF=7.848] Mingyue Zhou et al."Oriented Layered Graphene Oxide Pad Favoring High Loading Capacity and Stability for High-Throughput Chemical Screening."Advanced Materials Technologies. 2022 Mar 11 30. [IF=5.81] Jieli Pan et al.Up-Regulation of p53/miR-628-3p Pathway, a Novel Mechanism of Shikonin on Inhibiting Proliferation and Inducing Apoptosis of A549 and PC-9 Non-Small Cell Lung Cancer Cell Lines.Front Pharmacol. 2021 Nov 16;12:766165 29. [IF=1.312] Xu Wang et al."Microwave-assisted ionic liquid microextraction combined with high performance liquid chromatography for the determination of naphthoquinones from Arnebia euchroma (Royle) Johnst."Journal Of Liquid Chromatography & Related Technologies. 20 28. [IF=1.785] Fang Zhang et al."Non‑cytotoxic doses of shikonin inhibit lipopolysaccharide‑induced TNF‑α expression via activation of the AMP‑activated protein kinase signaling pathway."Exp Ther Med. 2020 Nov;20(5):1-1 27. [IF=2.952] Liying Sha et al."Shikonin inhibits the Warburg effect, cell proliferation, invasion and migration by downregulating PFKFB2 expression in lung cancer."Mol Med Rep. 2021 Aug;24(2):1-10 26. [IF=3.69] Chunfang Liu et al."Anti-angiogenic effect of Shikonin in rheumatoid arthritis by downregulating PI3K/AKT and MAPKs signaling pathways."J Ethnopharmacol. 2020 Oct;260:113039 25. [IF=4.545] Kai Chen et al."Shikonin mitigates ovariectomy-induced bone loss and RANKL-induced osteoclastogenesis via TRAF6-mediated signaling pathways."Biomed Pharmacother. 2020 Jun;126:110067 24. [IF=5.279] Wenqin Li et al."Discovery of Natural Products as Multitarget Inhibitors of Insect Chitinolytic Enzymes through High-Throughput Screening."J Agr Food Chem. 2021;69(37):10830–10837 23. [IF=5.455] He Lianhua et al."Shikonin attenuates rheumatoid arthritis by targeting SOCS1/JAK/STAT signaling pathway of fibroblast like synoviocytes."Chin Med-Uk. 2021 Dec;16(1):1-15 22. [IF=5.81] Liu Yun-zi et al."Pyruvate Kinase M2 Mediates Glycolysis Contributes to Psoriasis by Promoting Keratinocyte Proliferation."Front Pharmacol. 2021 Oct;0:2888 21. [IF=1.312] Qi Zhang et al."Rapid and sensitive determination of shikonin and its derivatives in the roots of Arnebia euchroma (Royle) Johnst using matrix solid-phase dispersion extraction and ultrahigh-performance liquid chromatography with photodiode array detecto 20. [IF=2.896] Lu Wang et al."Rapid assay for testing superoxide anion radical scavenging activities to natural pigments by ultra-high performance liquid chromatography-diode-array detection method."Anal Methods-Uk. 2015 Feb;7(4):1535-1542 19. [IF=2.985] Chao Yang et al."Shikonin exerts anti-inflammatory effects in LPS-induced mastitis by inhibiting NF-κB signaling pathway."Biochem Bioph Res Co. 2018 Oct;505:1 18. [IF=3.06] Xianchun Wen et al."Anticancer Efficacy of Targeted Shikonin Liposomes Modified with RGD in Breast Cancer Cells."Molecules. 2018 Feb;23(2):268 17. [IF=3.547] Heyong Wang et al."Shikonin attenuates lung cancer cell adhesion to extracellular matrix and metastasis by inhibiting integrin β1 expression and the ERK1/2 signaling pathway."Toxicology. 2013 Jun;308:104 16. Chunfang Liu, Lianhua He, Jingxia Wang, Qianqian Wang, Congcong Sun, Yiqun Li, Kexin Jia, Jinxia Wang, Tengteng Xu, Ruirui Ming, Qingwen Wang, Na Lin, Anti-angiogenic effect of Shikonin in rheumatoid arthritis by downregulating PI3K/AKT and MAPKs signaling 15. Han Y, Shen M, Tang LY, Tan G, Yang QC, Ye L, Ye LH, Jiang N, Gao GP, Shao Y, Shao Y, et al: Antiangiogenic effects of catalpol on rat corneal neovascularization. Mol Med Rep 17: 2187-2194, 2018 14. Wen, Xianchun, et al. "Anticancer efficacy of targeted shikonin liposomes modified with RGD in breast cancer cells." Molecules 23.2 (2018): 268.https://doi.org/10.3390/molecules23020268 13. Heyong Wang, Chunlian Wu, Shengbang Wan, Huijun Zhang, Songwen Zhou, Gentao Liu, Shikonin attenuates lung cancer cell adhesion to extracellular matrix and metastasis by inhibiting integrin β1 expression and the ERK1/2 signaling pathway, Toxicology, Volume 12. Chao Yang, Pei Liu, Shuang Wang, Gan Zhao, Tao Zhang, Shuai Guo, KangFeng Jiang, HaiChong Wu, Ganzhen Deng, Shikonin exerts anti-inflammatory effects in LPS-induced mastitis by inhibiting NF-κB signaling pathway, Biochemical and Biophysical Research Commun 11. 崔伟亮. 丹参酒炙前后HPLC指纹图谱色谱峰归属比较[J]. 辽宁中医杂志, v.46;No.507(08):1707-1709. 10. 牛敏 刘红燕 刘谦 等. 4个栽培年限丹参颜色与9种活性成分含量的相关性[J]. 中成药 2017(1):131-135. 9. 孙健文 温宪春 蔡德富 等. RP-HPLC法同时测定新疆紫草中紫草素、乙酰紫草素、β β-二甲基丙烯酰紫草素的含量[J]. 中国药房 2018 v.29;No.622(04):455-457. 8. 徐翊雯, 袁瑞娟, 董洁,等. 紫草素锌配合物的合成及其对人宫颈癌HeLa细胞的抑制作用[J]. 中医学报, 2016(3):316-318. 7. 路京, 陈子龙, 闵朕,等. 紫草素逆转由肝细胞生长因子诱导的肺癌吉非替尼耐药[J]. 中国病理生理杂志, 2019, 35(01):68-73. 6. 王媛, 刘莉, 陆远,等. 紫草素逆转埃克替尼对肺癌EGFR-TKI耐药及其机制的研究[J]. 现代生物医学进展, 2016, 16(016):3044-3047. 5. 魏玉, 康冰亚, 张明昊,等. 紫草素纳米乳的制备及其稳定性考察[J]. 时珍国医国药, 2018, 29(12):2932-2935. 4. 赵莎, 潘敏, 陈菲菲,等. 紫草素对银屑病样动物模型Th17细胞相关因子的影响[J]. 临床皮肤科杂志, 2016, 045(005):323-327. 3. 周海, 伍春莲, 徐佳,等. 紫草素对人结肠癌细胞Lovo增殖与凋亡的影响[J]. 西华师范大学学报(自然科学版), 2014, 35(002):135-139. 2. 李发凯, 张芳, 陆远,等. 紫草素促进肺癌A549细胞凋亡[J]. 现代生物医学进展, 2018, 018(009):1611-1615,1673. 1. 顾依 周琴 刘馨 刁和芳 陈志鹏 陈瑞 朱辰奇.丹参聚多巴胺纳米递药系统的构建及对H_2O_2诱导心肌细胞氧化损伤的保护作用研究[J].中草药 2020 51(14):3655-3662.