• 介绍：

   是一种口服有效、能透过血脑屏障的半合成四环素类抗生素。Minocycline hydrochloride 是一种缺氧诱导因子 (HIF-1α) 抑制剂。Minocycline hydrochloride 具有抗癌(anti-cancer)，抗炎(anti-inflammatory) 和谷氨酸 (glutamate) 拮抗作用。Minocycline hydrochloride 降低谷氨酸神经传递，显示神经保护特性和抗抑郁作用。Minocycline hydrochloride 通过与细菌核糖体30S亚基结合，抑制细菌蛋白的合成，从而产生抑菌 (bacteriostatic) 作用。

• 熔点： 205-210° (d°C)

• 沸点： 659.4°C at 760mmHg

• 外观： 嫩黄色至橙色非晶形固体

• 溶解性： DMSO  :  19.23  mg/mL  (38.93  mM;  Need  ultrasonic)
  
  H2O  :  10  mg/mL  (20.25  mM;  Need  ultrasonic)

• 敏感性： 对光敏感

• 储存条件： 2-8℃

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

• 18. [5.9] Xingdu Chen et al."Biotransformation of minocycline by a novel strain Kluyvera sp. DM13 isolated from municipal sludge: Performances, removal pathways, and toxicity."Journal of Environmental Sciences.2024 Jul;:

• 17. [IF=4.3] Pengfei Gao et al."A rapid solid-phase extraction purification combined with UPLCMS/MS used for simultaneous determination of eight tetracyclines and three metabolite in chicken and pork."JOURNAL OF FOOD COMPOSITION AND ANALYSIS".2024 Aug;132:106317

• 16. [IF=15.1] Meng-Yan Deng et al."Dexamethasone attenuates neuropathic pain through spinal microglial expression of dynorphin A via the cAMP/PKA/p38 MAPK/CREB signaling pathway."BRAIN BEHAVIOR AND IMMUNITY".2024 Jul;119:36

• 15. [IF=2.032] Xu Han et al."Minocycline induces tolerance to dendritic cell production probably by targeting the SOCS1/ TLR4/NF-κB signaling pathway."TRANSPLANT IMMUNOLOGY.2023 Aug;79:101856

• 14. [9.043] Chun-Yan Le et al."Hinokitiol Selectively Enhances the Antibacterial Activity of Tetracyclines against Staphylococcus aureus."Microbiology Spectrum.

• 13. [IF=3.631] Zhiya Yang et al."5-aminolevulinic acid-photodynamic therapy ameliorates cutaneous granuloma by killing drug-resistant Mycobacterium marinum."Photodiagn Photodyn. 2022 Mar;:102839

• 12. [IF=3.093] Huang Sheng-Nan et al."Bulleyaconitine A Inhibits Visceral Nociception and Spinal Synaptic Plasticity through Stimulation of Microglial Release of Dynorphin A."Neural Plast. 2020;2020:1484087

• 11. [IF=3.575] Xueqi Tang et al."The GLP-1 receptor herbal agonist morroniside attenuates neuropathic pain via spinal microglial expression of IL-10 and β-endorphin."Biochem Bioph Res Co. 2020 Sep;530:494

• 10. [IF=3.599] Ma Le et al."Microglial Activation of GLP-1R Signaling in Neuropathic Pain Promotes Gene Expression Adaption Involved in Inflammatory Responses."Neural Plast. 2021;2021:9923537

• 9. [IF=4.223] Yuan et al."Efficient degradation of minocycline by natural bornite-activated hydrogen peroxide and persulfate: kinetics and mechanisms."Environmental Science And Pollution Research. 2021 Jul 22

• 8. [IF=4.545] Usman Ali et al."Low frequency electroacupuncture alleviates neuropathic pain by activation of spinal microglial IL-10/β-endorphin pathway."Biomed Pharmacother. 2020 May;125:109898

• 7. [IF=5.243] Le Ma et al."Spinal microglial β‐endorphin signaling mediates IL‐10 and exenatide‐induced inhibition of synaptic plasticity in neuropathic pain."Cns Neurosci Ther. 2021 Oct; 27(10): 1157–1172

• 6. [IF=5.81] Zhao Meng-Jing et al."Bulleyaconitine A Inhibits Morphine-Induced Withdrawal Symptoms, Conditioned Place Preference, and Locomotor Sensitization Via Microglial Dynorphin A Expression."Front Pharmacol. 2021 Feb;0:92

• 5. [IF=5.858] Meng-Yan Deng et al."Thalidomide alleviates neuropathic pain through microglial IL-10/β-endorphin signaling pathway."Biochem Pharmacol. 2021 Oct;192:114727

• 4. [IF=7.217] Khalil Ali Ahmad et al."Microglial IL-10 and β-endorphin expression mediates gabapentinoids antineuropathic pain."Brain Behav Immun. 2021 Jul;95:344

• 3. [IF=8.322] Apryani Evhy et al."The spinal microglial IL-10/β-endorphin pathway accounts for cinobufagin-induced mechanical antiallodynia in bone cancer pain following activation of α7-nicotinic acetylcholine receptors."J Neuroinflamm. 2020 Dec;17(1):1-18

• 2. [IF=4.36] Qian Huang et al."Concurrent bullatine A enhances morphine antinociception and inhibits morphine antinociceptive tolerance by indirect activation of spinal κ-opioid receptors."J Ethnopharmacol. 2017 Jan;196:151

• 1. [IF=6.17] Qian Huang et al."Cynandione A attenuates neuropathic pain through p38β MAPK-mediated spinal microglial expression of β-endorphin."Brain Behav Immun. 2017 May;62:64

输入产品批号：

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *