SB 4

    
99%

SB 4

源叶(MedMol)
S23276 一键复制产品信息
100874-08-6
C14H10BrNOS
320.20
BMP signaling agonist sb4
货号 规格 价格 上海 北京 武汉 南京 购买数量
S23276-5mg 99% ¥136.00 8 - - -
S23276-10mg 99% ¥204.00 8 - - -
S23276-25mg 99% ¥360.00 10 - - -
S23276-100mg 99% ¥820.00 7 - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品

产品介绍

SB 4 是一种 bone morphogenetic protein 4 (BMP4) signaling 的有效的选择性激动剂,其EC50值为74 nM。SB 4可增强经典的BMP信号传导并激活 SMAD-1/5/9 磷酸化

产品描述: SB 4 是一种 bone morphogenetic protein 4 (BMP4) signaling 的有效的选择性激动剂,其EC50值为74 nM。SB 4可增强经典的BMP信号传导并激活 SMAD-1/5/9 磷酸化
靶点: BMP4(Cell-free assay):74 nM(EC50);TGF-beta/Smad
体外研究: BMP signaling agonist sb4 (0.05 μM-1 μM; 24 hours) induces phosphorylated SMAD-1/5/9 in a dose-dependent manner in PRECs cells under serum-starved conitions.
BMP signaling agonist sb4 (1 μM; 0-60 mins) enhances the efficacy of signaling at each concentration of rhBMP4 tested. This effect is most pronounced at low concentrations of rhBMP4, whereby sb4 increases BRE-luc expression 2-fold at 0.4 ng/ml of rhBMP4.
细胞实验: Cell lines: Primary mouse kidney epithelial cells (PRECs) Concentrations: 0.05 μM-1 μM Incubation Time: 0-1 h, 24 h Method: The BRE-Luc cells are stimulated with 2 ng/ml rhBMP4 for 1 h, after which the media are removed and replaced with fresh media containing either DMSO or 1 μm SB 4. p-SMAD-1/5/9 levels are then examined after 0, 5, 15, 30, 45, and 60 min of SB 4 treatment and compared with DMSO controls.
参考文献: 1. Bradford STJ, Ranghini EJ, Grimley E, Lee PH, Dressler GR. High-throughput screens for agonists of bone morphogenetic protein (BMP) signaling identify potent benzoxazole compounds. J Biol Chem. 2019 Mar 1;294(9):3125-3136.
溶解性: Soluble  in  DMSO、Ethanol
保存条件: -20℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 3.123 ml 15.615 ml 31.23 ml
5 mM 0.625 ml 3.123 ml 6.246 ml
10 mM 0.312 ml 1.562 ml 3.123 ml
50 mM 0.062 ml 0.312 ml 0.625 ml
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参考文献

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