品牌	货号	产品规格	价格(RMB)	库存（上海）	北京	武汉	南京
源叶(MedMol)	S23457-5mg	98%	￥300.00元	4	-	-	-
源叶(MedMol)	S23457-25mg	98%	￥500.00元	3	-	-	-
源叶(MedMol)	S23457-100mg	98%	￥950.00元	9	-	-	-

品牌

货号

产品规格

价格(RMB)

库存（上海）

北京

武汉

南京

购买数量

源叶(MedMol)

S23457-5mg

98%

￥300.00元

源叶(MedMol)

S23457-25mg

98%

￥500.00元

源叶(MedMol)

S23457-100mg

98%

￥950.00元

产品介绍

MMP-9-IN-1 is a specific matrix metalloproteinase-9 (MMP-9) inhibitor, which selectively target the hemopexin (PEX) domain of MMP-9, but not other MMPs

产品描述：

MMP-9-IN-1 is a specific matrix metalloproteinase-9 (MMP-9) inhibitor, which selectively target the hemopexin (PEX) domain of MMP-9, but not other MMPs

靶点：

MMP-9;MMP

体外研究：

MMP-9-IN-1 (compound 2; 100 μM; 14 hours) does not cause notable cytotoxicity.

MMP-9-IN-1 (compound 2; 10 μM) significantly inhibits cell proliferation of HT-1080 and MDA-MB-435 cells.

体内研究：

MMP-9-IN-1 (compound 2; 20 mg/kg; intraperitoneal and intratumoral injection alternately; 6 days/week; for 14 weeks) results in a profound delay in tumor growth in NCR-Nu mice bearing MDA-MB-435/GFP tumor.

MMP-9-IN-1 inhibits cancer cell metastasis in vivo. Animal Model: 4-5 week-old female NCR-Nu mice bearing MDA-MB-435/GFP tumor Dosage: 20 mg/kg Administration: Intraperitoneal and intratumoral injection alternately; 6 days/week; for 14 weeks, Result: Resulted in a profound delay in tumor growth. Inhibited cancer cell metastasis.

参考文献：

1. Dufour A, et al. Small-molecule anticancer compounds selectively target the hemopexin domain of matrix metalloproteinase-9. Cancer Res. 2011 Jul 15;71(14):4977-88.

2. Alford VM, Kamath A, Ren X, et al. Targeting the Hemopexin-like Domain of Latent Matrix Metalloproteinase-9 (proMMP-9) with a Small Molecule Inhibitor Prevents the Formation of Focal Adhesion Junctions. ACS Chem Biol. 2017;12(11):2788-2803.

溶解性：

Soluble in DMSO

保存条件：

2-8℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.707 ml	13.536 ml	27.072 ml
5 mM	0.541 ml	2.707 ml	5.414 ml
10 mM	0.271 ml	1.354 ml	2.707 ml
50 mM	0.054 ml	0.271 ml	0.541 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

质检证书(COA)

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

MMP-9-IN-1 98%

N-(4-(Difluoromethoxy)phenyl)-2-((6-oxo-4-propyl-1,6-dihydropyrimidin-2-yl)thio)acetamide

产品介绍

参考文献

质检证书(COA)

如何获取质检证书(COA)?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

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