• 产品描述： PS-48 是 phosphoinositide-dependent protein kinase-1 (PDK1) 的变构激活剂

• 靶点： PDK1;PDK

• 体内研究：
  In vivo, the PDK1 agonist PS48 can maintain the bone mass of mice treated with dexamethasone

• 细胞实验： Cell lines: MC3T3-E1 cells Concentrations: 5 μM Incubation Time: -- Method: MC3T3-E1 cells are cultured in an osteogenic differentiation medium containing 4 mM glycerophosphate and 25 μg/mL ascorbic acid until 70% confluency. Dexamethasone (final concentration of ethanol, 0.01%, vol/vol) at different concentrations is then added to the osteogenic differentiation medium for 14 days. The culture medium is replaced every two days. MC3T3-E1 cells are cultured in a culture medium containing 10−7 M dexamethasone supplemented with or without PS48 (5 μM).

• 动物实验： Animal Models: 8-week-old male C57BL/6J mice Dosages: -- Administration: --

• 参考文献：
  1. Valerie Hindie, et al.Nat Chem Biol. 2009 Oct;5(10):758-64. 2. Wen-Ning Xu, et al. Front Endocrinol (Lausanne). 2020 Jan 28;10:922.

• 溶解性： Soluble  in  DMSO、Ethanol

• 保存条件： -20℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	3.487 ml	17.437 ml	34.873 ml
  5 mM	0.697 ml	3.487 ml	6.975 ml
  10 mM	0.349 ml	1.744 ml	3.487 ml
  50 mM	0.07 ml	0.349 ml	0.697 ml

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *