Tenovin 6 98%

Tenovin 6

源叶(MedMol)
S80019
1011557-82-6
C25H34N4O2S
454.63
品牌 货号 产品规格 价格(RMB) 库存(上海) 北京 武汉 南京 购买数量
源叶(MedMol) S80019-1mg 98% ¥435.20元 10 - - -
源叶(MedMol) S80019-5mg 98% ¥760.00元 5 - - -
源叶(MedMol) S80019-10mg 98% ¥1460.00元 6 - - -
源叶(MedMol) S80019-25mg 98% ¥2220.00元 6 - - -
源叶(MedMol) S80019-50mg 98% ¥4420.00元 预计交期:2-3天 - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品

产品介绍

Tenovin-6, an analog of Tenovin-1 (HY-13423), is an activator of p53 transcriptional activity. Tenovin-6 inhibits the protein deacetylase activities of purified human SIRT1, SIRT2, and SIRT3 with IC50s of 21 μM, 10 μM, and 67 μM, respectively. Tenovin-6 also inhibits dihydroorotate dehydrogenase (DHODH)
产品描述: Tenovin-6, an analog of Tenovin-1 (HY-13423), is an activator of p53 transcriptional activity. Tenovin-6 inhibits the protein deacetylase activities of purified human SIRT1, SIRT2, and SIRT3 with IC50s of 21 μM, 10 μM, and 67 μM, respectively. Tenovin-6 also inhibits dihydroorotate dehydrogenase (DHODH)
靶点: SIRT2:10 μM (IC50);SIRT1:21 μM (IC50);SIRT3:67 μM (IC50);HDAC8;MDM-2/p53;Dehydrogenase;Sirtuin;Autophagy
体内研究: Tenovin-6 (50 mg/kg, i.p.) inhibits the growth of tumor in mice
参考文献: 1. Lain S, et al. Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator. Cancer Cell. 2008 May;13(5):454-63. 2. Ladds MJGW, et al. Exploitation of DHODH and p53 activation as therapeutic targets - a case study in polypharmacology [published online ahead of print, 2020 Sep 8]. J Biol Chem. 2020;jbc.RA119.012056. 3. Dai W, et al. Class III-specific HDAC inhibitor Tenovin-6 induces apoptosis, suppresses migration and eliminates cancer stem cells in uveal melanoma. Sci Rep. 2016 Mar 4;6:22622. 4. Yuan H, et al. Tenovin-6 impairs autophagy by inhibiting autophagic flux. Cell Death Dis. 2017 Feb 9;8(2):e2608. 5. Yuan H, et al. Tenovin-6 inhibits proliferation and survival of diffuse large B-cell lymphoma cells by blocking autophagy. Oncotarget. 2017 Feb 28;8(9):14912-14924.
溶解性: DMSO  :  ≥  31  mg/mL  (68.19  mM)
保存条件: 2-8℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 2.2 ml 10.998 ml 21.996 ml
5 mM 0.44 ml 2.2 ml 4.399 ml
10 mM 0.22 ml 1.1 ml 2.2 ml
50 mM 0.044 ml 0.22 ml 0.44 ml
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参考文献

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