Taltirelin

    
≥98%

Taltirelin

源叶(MedMol)
S80042 一键复制产品信息
103300-74-9
C17H23N7O5
405.408
他替瑞林;(4S)-N-[(2S)-1-[(2S)-2-氨基甲酰基吡咯烷-1-基]-3-(3H-咪唑-4-基)-1-氧代丙-2-基]-1-甲基-2,6-二氧代-1,3-二氮杂己环-4-甲酰胺;醋酸他替瑞林;1-METHYL-4,5-DIHYDROOROTYL-HIS-PRO-NH2;L-Prolinamide, N-[(hexahydro-1-methyl-2,6-dioxo-4-pyrimidi
货号 规格 价格 上海 北京 武汉 南京 购买数量
S80042-1mg ≥98% ¥170.00 4 - - -
S80042-5mg ≥98% ¥600.00 7 - - -
S80042-10mg ≥98% ¥900.00 6 - - -
S80042-25mg ≥98% ¥1900.00 6 - - -
S80042-50mg ≥98% ¥3300.00 5 - - -
S80042-100mg ≥98% ¥6000.00 3 - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品

产品介绍

Taltirelin is at thyrotropin-releasing hormone receptor (TRH-R) superagonist (IC50 of 910 nM and EC50 of 36 nM for stimulating an increase in cytosolic Ca2+ concentration (Ca2+ release))

产品描述: Taltirelin is at thyrotropin-releasing hormone receptor (TRH-R) superagonist (IC50 of 910 nM and EC50 of 36 nM for stimulating an increase in cytosolic Ca2+ concentration (Ca2+ release))
靶点: Thyroid hormone receptor(THR);Thyroidhormonereceptor(THR)
体内研究: Taltirelin (TAL), in mouse models of CRF.To model fatigue, we used a mouse model of chemotherapy, a mouse model of radiation therapy, and mice bearing colon 26 carcinoma tumors.?We used the treadmill fatigue test to assess fatigue-like behavior after treatment with TAL.Additionally, we used wild-type and TRH receptor knockout mice to determine which TRH receptor was necessary for the actions of TAL.Tumor-bearing mice displayed muscle wasting and all models caused fatigue-like behavior, with mice running a shorter distance in the treadmill fatigue test than controls.?TAL reversed fatigue-like behavior in all three models and the mouse TRH1 receptor was necessary for the effects of TAL.These data suggest that TAL may be useful in alleviating fatigue in all cancer patients and provide further support for evaluating TAL as a potential therapy for CRF in humans
参考文献: 1. Thirunarayanan N, et al. Taltirelin is a superagonist at the human thyrotropin-releasing hormone receptor. Front Endocrinol (Lausanne). 2012 Oct 9;3:120. 2. Dougherty J P , Wolff B S , Cullen M J , et al. Taltirelin alleviates fatigue-like behavior in mouse models of cancer-related fatigue.[J]. Pharmacological Research, 2017, 124:1-8.
溶解性: Soluble  in  DMSO
保存条件: -20℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 2.467 ml 12.333 ml 24.667 ml
5 mM 0.493 ml 2.467 ml 4.933 ml
10 mM 0.247 ml 1.233 ml 2.467 ml
50 mM 0.049 ml 0.247 ml 0.493 ml
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参考文献

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摩尔浓度计算器

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