货号	规格	价格	上海	北京	武汉	南京
S80047-1mg	99%	￥50.00 S80047-1mg ￥50.00 现货	7 7	-	-	-
S80047-2mg	99%	￥80.00 S80047-2mg ￥80.00 现货	4 4	-	-	-
S80047-5mg	99%	￥100.00 S80047-5mg ￥100.00 现货	8 8	-	-	-
S80047-10mg	99%	￥180.00 S80047-10mg ￥180.00 现货	6 6	-	-	-
S80047-50mg	99%	￥710.00 S80047-50mg ￥710.00 现货	6 6	-	-	-
S80047-100mg	99%	￥1290.00 S80047-100mg ￥1290.00 2-3天	0 货期：2-3天	-	-	-

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产品介绍

Bemcentinib (R428) is a potent and selective inhibitor of Axl with an IC50 of 14 nM

产品描述：

Bemcentinib (R428) is a potent and selective inhibitor of Axl with an IC50 of 14 nM

靶点：

IC50: 14 nM (Axl kinase);TAMReceptor

体内研究：

Bemcentinib (R428) (125 mg/kg, p.o.) significantly blocks MDA-MB-231-luc-D3H2LN metastases development in two independent mouse models of breast cancer dissemination, suppresses both tumor angiogenesis and vascular endothelial growth factor (VEGF)-induced corneal neovascularization in vivo. Bemcentinib (R428) (75 mg/kg/day, 25 mg/kg twice daily, p.o.) makes mice keep on a high-fat diet resulted in significantly reduced weight gain and subcutaneous and gonadal fat mass

参考文献：

1. Sensi M, et al. Human cutaneous melanomas lacking MITF and melanocyte differentiation antigens express a functional Axl receptor kinase. J Invest Dermatol. 2011 Dec;131(12):2448-57. 2. Holland SJ, et al. R428, a selective small molecule inhibitor of Axl kinase, blocks tumor spread and prolongs survival in models of metastatic breast cancer. Cancer Res. 2010 Feb 15;70(4):1544-54. 3. Lijnen HR, et al. Growth arrest-specific protein 6 receptor antagonism impairs adipocyte differentiation and adipose tissue development in mice. J Pharmacol Exp Ther. 2011 May;337(2):457-64.

溶解性：

DMSO : 25 mg/mL (49.34 mM; ultrasonic and warming and heat to 60°C)

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.974 ml	9.869 ml	19.738 ml
5 mM	0.395 ml	1.974 ml	3.948 ml
10 mM	0.197 ml	0.987 ml	1.974 ml
50 mM	0.039 ml	0.197 ml	0.395 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

R428 (BGB324)