Mizolastine 98%

Mizolastine

源叶(MedMol)
S80080
108612-45-9
C24H25FN6O
432.49
4(3H)-Pyrimidinone, 2-[[1-[1-[(4-fluorophenyl)methyl]-1H-benzimidazol-2-yl]-4-piperidinyl]methylamino]-
品牌 货号 产品规格 价格(RMB) 库存(上海) 北京 武汉 南京 购买数量
源叶(MedMol) S80080-100mg 98% ¥340.00元 7 - - -
源叶(MedMol) S80080-500mg 98% ¥850.00元 预计交期:2-3天 - - -
源叶(MedMol) S80080-1g 98% ¥1500.00元 预计交期:2-3天 - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品

产品介绍

Mizolastine is an orally active, high affinity and specific peripheral histamine H1 receptor antagonist (second generation antihistamine). Mizolastine effectively inhibits mRNA expression of VEGF165, VEGF120, TNF-α and KC. Mizolastine can be used in studies of allergic rhinitis and chronic idiopathic urticarial
产品描述: Mizolastine is an orally active, high affinity and specific peripheral histamine H1 receptor antagonist (second generation antihistamine). Mizolastine effectively inhibits mRNA expression of VEGF165, VEGF120, TNF-α and KC. Mizolastine can be used in studies of allergic rhinitis and chronic idiopathic urticarial
靶点: Histamine Receptor;HistamineReceptor
体内研究: Mizolastine (0.3 mg/kg; p.o.; single daily for 7 days) inhibits production of 5-LOX AA (arachidonic acid) metabolite leukotriene B4 (LTB4), and suppresses expression of 5-LOX, cytosolic PLA2 (cPLA2), 5-LOX-activating protein, and LTB4 receptor mRNA in the AA-induced inflammation model
参考文献: 1. Xia Q, et al. The effect of mizolastine on expression of vascular endothelial cell growth factor, tumour necrosis factor-alpha and keratinocyte-derived chemokine in murine mast cells, compared with dexamethasone and loratadine. Clin Exp Dermatol. 2005 Mar 2. Ren X, et al. The anti-inflammatory effects of Yunnan Baiyao are involved in regulation of the phospholipase A2/arachidonic acid metabolites pathways in acute inflammation rat model. Mol Med Rep. 2017 Oct;16(4):4045-4053. 3. Prakash A, et al. Mizolastine: a review of its use in allergic rhinitis and chronic idiopathic urticaria. BioDrugs. 1998 Jul;10(1):41-63.
溶解性: DMSO  :  25  mg/mL  (57.80  mM;  Need  ultrasonic)    H2O  :  1  mg/mL  (2.31  mM;  ultrasonic  and  warming  and  heat  to  80°C)
保存条件: -20℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 2.312 ml 11.561 ml 23.122 ml
5 mM 0.462 ml 2.312 ml 4.624 ml
10 mM 0.231 ml 1.156 ml 2.312 ml
50 mM 0.046 ml 0.231 ml 0.462 ml
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参考文献

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