VU 0361737 99%

VU 0361737

源叶(MedMol)
S80132
1161205-04-4
C13H11ClN2O2
262.69
MFCD16618402
2-Pyridinecarboxamide, N-(4-chloro-3-methoxyphenyl)-
品牌 货号 产品规格 价格(RMB) 库存(上海) 北京 武汉 南京 购买数量
源叶(MedMol) S80132-2mg 99% ¥125.00元 5 - - -
源叶(MedMol) S80132-5mg 99% ¥240.00元 6 - - -
源叶(MedMol) S80132-10mg 99% ¥275.00元 6 - - -
源叶(MedMol) S80132-25mg 99% ¥600.00元 6 - - -
源叶(MedMol) S80132-50mg 99% ¥1050.00元 预计交期:2-3天 - - -
源叶(MedMol) S80132-100mg 99% ¥2000.00元 预计交期:2-3天 - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品

产品介绍

VU0361737 (ML-128) is a potent, selective and CNS penetrant positive allosteric modulator of metabotropic glutamate receptor 4 (mGluR4 PAM), with EC50s of 240 nM and 110 nM for human and rat mGluR4 receptors, respectively. VU0361737 has neuroprotective effect. VU0361737 is potential for Parkinson's disease research
产品描述: VU0361737 (ML-128) is a potent, selective and CNS penetrant positive allosteric modulator of metabotropic glutamate receptor 4 (mGluR4 PAM), with EC50s of 240 nM and 110 nM for human and rat mGluR4 receptors, respectively. VU0361737 has neuroprotective effect. VU0361737 is potential for Parkinson's disease research
靶点: Human mGlu4:240 nM (EC50);Rat mGlu4:110 nM (EC50);GluR
体内研究: VU0361737 exhibits terminal elimination half-lives (rat 1.9 h) due to high plasma clearance (894 mL/min/kg) following Intraperitoneal injection ( rat 10 mg/kg)
参考文献: 1. Engers DW, et al. Synthesis and evaluation of a series of heterobiarylamides that are centrally penetrant metabotropic glutamate receptor 4 (mGluR4) positive allosteric modulators (PAMs). J Med Chem. 2009 Jul 23;52(14):4115-8. 2. Engers DW, et al. Discovery, synthesis, and structure-activity relationship development of a series of N-(4-acetamido)phenylpicolinamides as positive allosteric modulators of metabotropic glutamate receptor 4 (mGlu(4)) with CNS exposure in rats. J Med Ch 3. Jantas D, et al. Neuroprotective effects of mGluR II and III activators against staurosporine- and doxorubicin-induced cellular injury in SH-SY5Y cells: New evidence for a mechanism involving inhibition of AIF translocation. Neurochem Int. 2015 Sep;88:124
溶解性: DMSO  :  100  mg/mL  (380.68  mM;  Need  ultrasonic)
保存条件: -20℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 3.807 ml 19.034 ml 38.068 ml
5 mM 0.761 ml 3.807 ml 7.614 ml
10 mM 0.381 ml 1.903 ml 3.807 ml
50 mM 0.076 ml 0.381 ml 0.761 ml
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参考文献

质检证书(COA)

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