货号	规格	价格	上海	北京	武汉	南京
S80139-2mg	99.9%	￥100.00 S80139-2mg ￥100.00 现货	4 4	-	-	-
S80139-5mg	99.9%	￥126.00 S80139-5mg ￥126.00 现货	5 5	-	-	-
S80139-10mg	99.9%	￥200.00 S80139-10mg ￥200.00 现货	6 6	-	-	-
S80139-25mg	99.9%	￥425.00 S80139-25mg ￥425.00 现货	5 5	-	-	-
S80139-50mg	≥98%	￥700.00 S80139-50mg ￥700.00 2-3天	0 货期：2-3天	-	-	-
S80139-100mg	≥98%	￥1160.00 S80139-100mg ￥1160.00 2-3天	0 货期：2-3天	-	-	-

大包装询价收藏产品

加入购物车

产品介绍

AZD-2461 is a potent PARP inhibitor, with IC50s of 5 nM, 2 nM and 200 nM for PARP1, PARP2 and PARP3, respectively.

产品描述：

AZD-2461 is a potent PARP inhibitor, with IC50s of 5 nM, 2 nM and 200 nM for PARP1, PARP2 and PARP3, respectively.

靶点：

PARP2:2 nM (IC50);PARP1:5 nM (IC50);PARP3:200 nM (IC50);PARP

体内研究：

AZD-2461 (10 mg/kg, p.o.) enhances the antitumor activity of temozolomide in a mouse colorectal xenograft and exhibits low effect on mouse bone marrow cells. However, the increased bone marrow tolerability of AZD-2461 is not seen in rat models. AZD-2461 (0.5% v/w HPMC, p.o.) increases the survival of mice bearing KB1P tumors after short-term treatment, and long-term treatment is well tolerated, but can not lead to tumor eradication

参考文献：

1. Oplustil O'Connor L, et al. The PARP Inhibitor AZD2461 Provides Insights into the Role of PARP3 Inhibition for Both Synthetic Lethality and Tolerability with Chemotherapy in Preclinical Models. Cancer Res. 2016 Oct 15;76(20):6084-6094. Epub 2016 Aug 22. 2. Węsierska-Gądek J, et al. Differential Potential of Pharmacological PARP Inhibitors for Inhibiting Cell Proliferation and Inducing Apoptosis in Human Breast Cancer Cells. J Cell Biochem. 2015 Dec;116(12):2824-39. 3. Jaspers JE, et al. Loss of 53BP1 causes PARP inhibitor resistance in Brca1-mutated mouse mammary tumors. Cancer Discov. 2013 Jan;3(1):68-81.

溶解性：

DMSO : ≥ 100 mg/mL (252.89 mM)

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.529 ml	12.644 ml	25.289 ml
5 mM	0.506 ml	2.529 ml	5.058 ml
10 mM	0.253 ml	1.264 ml	2.529 ml
50 mM	0.051 ml	0.253 ml	0.506 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

质检证书(COA)

输入产品批号：

如何获取质检证书(COA)?

请输入货号和一个与之匹配的批号。
例如:
批号：JS298415 货号：S20001-25g
在货品标签上如何找到货号和批号?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置