GSK2334470

    99%

GSK2334470

源叶(MedMol)
S80194
1227911-45-6
C25H34N8O
462.59
MFCD21608525
3-Piperidinecarboxamide, 1-[6-(3-amino-1H-indazol-6-yl)-2-(methylamino)-4-pyrimidinyl]-N-cyclohexyl-6-methyl-, (3S,6R)-
品牌 货号 产品规格 价格(RMB) 库存(上海) 北京 武汉 南京 购买数量
源叶(MedMol) S80194-10mg 99% ¥600.00元 3 - - -
源叶(MedMol) S80194-50mg 99% ¥2000.00元 2 - - -
源叶(MedMol) S80194-100mg 99% ¥3600.00元 预计交期:2-3天 - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品

产品介绍

GSK2334470 is a highly specific and potent inhibitor of PDK1 with an IC50 of 10 nM.
产品描述: GSK2334470 is a highly specific and potent inhibitor of PDK1 with an IC50 of 10 nM.
靶点: IC50: 10 nM(PDK1);PDK
体内研究: The efficacy of the PDK1 inhibitor (PDKi) GSK2334470 is tested in newborn BrafV600E::Pten−/−mice subjected to systemic administration of 4-HT. Twice weekly administration of PDK1 results in marked inhibition of pigmented lesions and concomitant melanomagenesis, as well as significant inhibition of lung metastases, seen by H&E staining-based quantification (~80%), and lymph node metastases as by S100 immunostaining, similar to the phenotype seen upon genetic ablation of Pdk1
参考文献: 1. Najafov A, et al. Characterization of GSK2334470, a novel and highly specific inhibitor of PDK1. Biochem J.?2011 Jan 15;433(2):357-69. 2. Qi L, et al. PDK1-mTOR signaling pathway inhibitors reduce cell proliferation in MK2206 resistant neuroblastoma cells. Cancer Cell Int.?2015 Sep 29;15:91. 3. Scortegagna M, et al. Genetic inactivation or pharmacological inhibition of Pdk1 delays development and inhibits metastasis of Braf(V600E)::Pten(-/-) melanoma. Oncogene. 2014 Aug 21;33(34):4330-9.
溶解性: DMSO  :  ≥  50  mg/mL  (108.09  mM)
保存条件: -20℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 2.162 ml 10.809 ml 21.617 ml
5 mM 0.432 ml 2.162 ml 4.323 ml
10 mM 0.216 ml 1.081 ml 2.162 ml
50 mM 0.043 ml 0.216 ml 0.432 ml
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参考文献

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摩尔浓度计算器

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