| 产品描述： | Idasanutlin (RG7388) is a potent and selective MDM2 antagonist, inhibiting p53-MDM2 binding, with an IC50 of 6 nM. |
| 靶点： |
IC50: 6 nM (p53-MDM2);Mdm2;E1/E2/E3Enzyme |
| 体内研究： |
Idasanutlin (RG7388, 25 mg/kg p.o.) results in tumor growth inhibition and regression, in the mouse SJSA human osteosarcoma xenograft model. Idasanutlin (RG7388) induces induction of apoptosis and antiproliferation, in the SJSA xenograft model |
| 参考文献： |
1. Ding Q, et al. Discovery of RG7388, a potent and selective p53-MDM2 inhibitor in clinical development. J Med Chem. 2013 Jul 25;56(14):5979-83. 2. Higgins B, et al. Preclinical optimization of MDM2 antagonist scheduling for cancer treatment by using a model-based approach. Clin Cancer Res. 2014, 20(14), 3742-3752. |
| 溶解性： |
DMSO : ≥ 45 mg/mL (73.00 mM) |
| 保存条件： |
-20℃ |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
1.622 ml |
8.111 ml |
16.221 ml |
| 5 mM |
0.324 ml |
1.622 ml |
3.244 ml |
| 10 mM |
0.162 ml |
0.811 ml |
1.622 ml |
| 50 mM |
0.032 ml |
0.162 ml |
0.324 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京