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产品描述： Azasetron (Y-25130) hydrochloride, a benzamide derivative, is a potent and selective 5-HT3 receptor antagonist. Azasetron is used in the study for Chemotherapy-induced nausea and vomiting (CINV) |
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靶点：
5-HT3 Receptor：0.33 nM (IC50);5-HTReceptor |
体内研究：
Azasetron could effectively penetrate through the skin and pass into the systemic circulation |
参考文献：
1. Sato, N., et al., Antagonistic activity of Y-25130 on 5-HT3 receptors. Jpn J Pharmacol, 1992. 59(4): p. 443-8. 2. Haga, K., et al., The effects of orally administered Y-25130, a selective serotonin3-receptor antagonist, on chemotherapeutic agent-induced emesis. Jpn J Pharmacol, 1993. 63(3): p. 377-83. |
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溶解性：
H2O : 20 mg/mL (51.78 mM; Need ultrasonic) DMSO : 2.22 mg/mL (5.75 mM; Need ultrasonic) |
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保存条件：
-20℃ |
配置溶液浓度参考：
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1mg |
5mg |
10mg |
| 1 mM |
2.589 ml |
12.944 ml |
25.889 ml |
| 5 mM |
0.518 ml |
2.589 ml |
5.178 ml |
| 10 mM |
0.259 ml |
1.294 ml |
2.589 ml |
| 50 mM |
0.052 ml |
0.259 ml |
0.518 ml |
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| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
北京