PF-4708671 99%

PF-4708671

源叶(MedMol)
S80229
1255517-76-0
C19H21F3N6
390.41
MFCD18086922
PF-04708671;1H-Benzimidazole, 2-[[4-(5-ethyl-4-pyrimidinyl)-1-piperazinyl]methyl]-6-(trifluoromethyl)-
品牌 货号 产品规格 价格(RMB) 库存(上海) 北京 武汉 南京 购买数量
源叶(MedMol) S80229-5mg 99% ¥196.00元 4 - - -
源叶(MedMol) S80229-10mg 99% ¥340.00元 7 - - -
源叶(MedMol) S80229-50mg 99% ¥680.00元 2 - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品

产品介绍

PF-4708671 is a potent cell-permeable S6K1 inhibitor with a Ki of 20 nM and IC50 of 160 nM.
产品描述: PF-4708671 is a potent cell-permeable S6K1 inhibitor with a Ki of 20 nM and IC50 of 160 nM.
靶点: S6K1:160 nM (IC50);S6K1:20 nM (Ki);S6K2:65 μM (IC50);S6Kinase;Autophagy
体内研究: The tumor growth rate in mice treated with the combination of OSI-906+PF-4708671 is significantly slower than that of OSI-906 alone (P=0.0189) or PF4708671 alone (P=0.0165) treated mice. The average tumor volume in the OSI-906+PF-4708671-treated mice is approximately 50% of that in mice treated with OSI-906 (P=0.0056) or PF-4708671 alone (P<0.001) at the end of a 15-day treatment
参考文献: 1. Pearce LR, et al. Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1). Biochem J. 2010 Oct 15;431(2):245-55. 2. Zhang Y, et al. Inhibition of p70S6K1 Activation by Pdcd4 Overcomes the Resistance to an IGF-1R/IR Inhibitor in Colon Carcinoma Cells. Mol Cancer Ther. 2015 Mar;14(3):799-809.
溶解性: DMSO  :  33.33  mg/mL  (85.37  mM;  Need  ultrasonic)
保存条件: -20℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 2.561 ml 12.807 ml 25.614 ml
5 mM 0.512 ml 2.561 ml 5.123 ml
10 mM 0.256 ml 1.281 ml 2.561 ml
50 mM 0.051 ml 0.256 ml 0.512 ml
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参考文献

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摩尔浓度计算器

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