货号	规格	价格	上海	北京	武汉	南京
S80229-5mg	99%	￥196.00 S80229-5mg ￥196.00 现货	4 4	-	-	-
S80229-10mg	99%	￥340.00 S80229-10mg ￥340.00 现货	7 7	-	-	-
S80229-50mg	99%	￥680.00 S80229-50mg ￥680.00 现货	2 2	-	-	-

产品介绍

PF-4708671 is a potent cell-permeable S6K1 inhibitor with a Ki of 20 nM and IC50 of 160 nM.

产品描述：

PF-4708671 is a potent cell-permeable S6K1 inhibitor with a Ki of 20 nM and IC50 of 160 nM.

靶点：

S6K1：160 nM (IC50)；S6K1：20 nM (Ki)；S6K2：65 μM (IC50);S6Kinase;Autophagy

体内研究：

The tumor growth rate in mice treated with the combination of OSI-906+PF-4708671 is significantly slower than that of OSI-906 alone (P=0.0189) or PF4708671 alone (P=0.0165) treated mice. The average tumor volume in the OSI-906+PF-4708671-treated mice is approximately 50% of that in mice treated with OSI-906 (P=0.0056) or PF-4708671 alone (P<0.001) at the end of a 15-day treatment

参考文献：

1. Pearce LR, et al. Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1). Biochem J. 2010 Oct 15;431(2):245-55. 2. Zhang Y, et al. Inhibition of p70S6K1 Activation by Pdcd4 Overcomes the Resistance to an IGF-1R/IR Inhibitor in Colon Carcinoma Cells. Mol Cancer Ther. 2015 Mar;14(3):799-809.

溶解性：

DMSO : 33.33 mg/mL (85.37 mM; Need ultrasonic)

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.561 ml	12.807 ml	25.614 ml
5 mM	0.512 ml	2.561 ml	5.123 ml
10 mM	0.256 ml	1.281 ml	2.561 ml
50 mM	0.051 ml	0.256 ml	0.512 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

质检证书(COA)

输入产品批号：

如何获取质检证书(COA)?

请输入货号和一个与之匹配的批号。
例如:
批号：JS298415 货号：S20001-25g
在货品标签上如何找到货号和批号?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

PF-4708671