产品描述: | PF-4708671 is a potent cell-permeable S6K1 inhibitor with a Ki of 20 nM and IC50 of 160 nM. |
靶点: |
S6K1:160 nM (IC50);S6K1:20 nM (Ki);S6K2:65 μM (IC50);S6Kinase;Autophagy |
体内研究: |
The tumor growth rate in mice treated with the combination of OSI-906+PF-4708671 is significantly slower than that of OSI-906 alone (P=0.0189) or PF4708671 alone (P=0.0165) treated mice. The average tumor volume in the OSI-906+PF-4708671-treated mice is approximately 50% of that in mice treated with OSI-906 (P=0.0056) or PF-4708671 alone (P<0.001) at the end of a 15-day treatment |
参考文献: |
1. Pearce LR, et al. Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1). Biochem J. 2010 Oct 15;431(2):245-55. 2. Zhang Y, et al. Inhibition of p70S6K1 Activation by Pdcd4 Overcomes the Resistance to an IGF-1R/IR Inhibitor in Colon Carcinoma Cells. Mol Cancer Ther. 2015 Mar;14(3):799-809. |
溶解性: |
DMSO : 33.33 mg/mL (85.37 mM; Need ultrasonic) |
保存条件: |
-20℃ |
配置溶液浓度参考: |
|
1mg |
5mg |
10mg |
1 mM |
2.561 ml |
12.807 ml |
25.614 ml |
5 mM |
0.512 ml |
2.561 ml |
5.123 ml |
10 mM |
0.256 ml |
1.281 ml |
2.561 ml |
50 mM |
0.051 ml |
0.256 ml |
0.512 ml |
|
注意: |
部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。 |