货号	规格	价格	上海	北京	武汉	南京
S80250-100mg	98%	￥1100.00 S80250-100mg ￥1100.00 现货	8 8	-	-	-
S80250-250mg	98%	￥1500.00 S80250-250mg ￥1500.00 现货	1 1	-	-	-
S80250-1g	98%	￥4000.00 S80250-1g ￥4000.00 现货	1 1	-	-	-

产品介绍

Bivalirudin is a reversible inhibitor of α- and ζ-thrombin (Kis = 2.56 and 1.84 nM, respectively), enzymes that exhibit high fibrinogen-clotting activities.

产品描述：

Bivalirudin is a reversible inhibitor of α- and ζ-thrombin (Kis = 2.56 and 1.84 nM, respectively), enzymes that exhibit high fibrinogen-clotting activities.

靶点：

Thrombin

体内研究：

Deposition in aspirin-treated groups receiving low-, medium-, and high-dose Bivalirudin decreased in a dose-dependent manner by 37%, 44%, and 56%, respectively. As the dose of Bivalirudin was increased, the plasma Bivalirudin levels and activated partial thromboplastin time ratios (final: initial) also increased in a dose-dependent manner. The mean plasma Bivalirudin levels ranged from 0.74 micrograms/ml in the low-dose Bivalirudin group to 2.55 micrograms/ml in the high-dose Bivalirudin group, and the corresponding activated partial thromboplastin time ratios were 1.5 and 3.3

动物实验：

Animals were randomly assigned to one of five groups: control (no aspirin or hirulog); aspirin alone (10 mg/kg); aspirin plus low-dose hirulog (0.2 mg/kg bolus followed by 0.5 mg/kg/hr); aspirin plus medium-dose hirulog (0.4 mg/kg bolus followed by 1.0 mg/kg/hr); or aspirin plus high-dose hirulog (0.6 mg/kg bolus followed by 1.5 mg/kg/hr). Hirulog was infused before surgery and continued until termination of the experiment 30 minutes after endarterectomy

参考文献：

1.Hamelink JK, et al. Inhibition of platelet deposition by combined hirulog and aspirin in a rat carotid endarterectomy model. J Vasc Surg. 1995 Mar;21(3):492-8. 2.Witting JI, et al. Thrombin-specific inhibition by and slow cleavage of hirulog-1. Biochem J. 1992 May 1;283 ( Pt 3):737-43. 3.Ofosu FA, et al. Inhibition of the amplification reactions of blood coagulation by site-specific inhibitors of alpha-thrombin. Biochem J. 1992 May 1;283 ( Pt 3):893-7.

溶解性：

DMSO:10 mM

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	0.459 ml	2.293 ml	4.587 ml
5 mM	0.092 ml	0.459 ml	0.917 ml
10 mM	0.046 ml	0.229 ml	0.459 ml
50 mM	0.009 ml	0.046 ml	0.092 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献(1篇)

1. 钟苗, 雷艳, 谭赫,等. 水提取法和仿生提取法研究菲牛蛭不同炮制品的体外抗凝活性[J]. 中国现代中药, 2020, v.22(03):75-79+93.

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

Bivalirudin