Win 55,212-2 Mesylate

    
≥98%(HPLC)

Win 55,212-2 Mesylate

源叶(MedMol)
S80272 一键复制产品信息
131543-23-2
C28H30N2O6S
522.61
(R)-(+)-WIN 55,212-2 甲磺酸盐;(R)-(5-Methyl-3-(morpholinoMethyl)-2,3-Dihydro-[1,4]Oxazino[2,3,4-hi]Indol-6-yl)(Naphthalen-1-yl)Methanone Methanesulfonate
货号 规格 价格 上海 北京 武汉 南京 购买数量
S80272-5mg ≥98%(HPLC) ¥299.00 9 - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品

产品介绍

WIN 55,212-2 Mesylate is a potent aminoalkylindole cannabinoid (CB) receptor agonist with Kis of 62.3 and 3.3 nM for human recombinant CB1 and CB2 receptors, respectively.

产品描述: WIN 55,212-2 Mesylate is a potent aminoalkylindole cannabinoid (CB) receptor agonist with Kis of 62.3 and 3.3 nM for human recombinant CB1 and CB2 receptors, respectively.
靶点: Ki: 62.3 nM (human recombinant CB1), 3.3 nM (human recombinant CB2)
体内研究: In the prefrontal cortex WIN 55,212-2 (0.1 and 1 mg/kg i.p.) increases dialysate glutamate levels from of the awake rat, while the lower (0.01 mg/kg) and the higher (2 mg/kg) doses are ineffective. Furthermore, the WIN 55,212-2 (0.1 mg/kg)- induced increase of dialysate glutamate levels is counteracted by pretreatment with the selective CB(1) receptor antagonist SR141716A (0.1 mg/kg, i.p.) and by the local perfusion with a low-calcium Ringer solution (Ca2+ 0.2 mM). WIN 55,212-2 (0.5, 1, 3, 5, 10 and 15 mg/kg, i.p.) does not alter the seizure threshold at low doses, while higher doses of the drug significantly increases the threshold in a dose-dependent manner. The anticonvulsant effect of WIN 55,212-2, which is observed with doses as high as 5 mg/kg, can be observed with doses as low as 0.5 mg/kg in groups pre-treated with 20 mg/kg of pioglitazone
参考文献: 1. Felder CC, et al. Comparison of the pharmacology and signal transduction of the human cannabinoid CB1 and CB2 receptors. Mol Pharmacol. 1995 Sep;48(3):443-50. 2. Ferraro L, et al. The cannabinoid receptor agonist WIN 55,212-2 regulates glutamate transmission in rat cerebral cortex: an in vivo and in vitro study. Cereb Cortex. 2001 Aug;11(8):728-33. 3. Price TJ, et al. Cannabinoid receptor-independent actions of the aminoalkylindole WIN 55,212-2 on trigeminal sensory neurons. Br J Pharmacol. 2004 May;142(2):257-66. 4. Payandemehr B, et al. Involvement of PPAR receptors in the anticonvulsant effects of a cannabinoid agonist, WIN 55,212-2. Prog Neuropsychopharmacol Biol Psychiatry. 2015 Mar 3;57:140-5
溶解性: DMSO  :  200  mg/mL  (382.69  mM;  Need  ultrasonic)
保存条件: -20℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 1.913 ml 9.567 ml 19.135 ml
5 mM 0.383 ml 1.913 ml 3.827 ml
10 mM 0.191 ml 0.957 ml 1.913 ml
50 mM 0.038 ml 0.191 ml 0.383 ml
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参考文献

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