| 产品描述： | Flavopiridol Hydrochloride (Alvocidib Hydrochloride) is a broad inhibitor of CDK, competing with ATP to inhibit CDKs including CDK1, CDK2, CDK4 with IC50s of 30, 170, 100 nM, respectively. |
| 靶点： |
CDK1/Cyc B1:30 nM (IC50);CDK2/Cyc E:170 nM (IC50);CDK4/Cyc D1:100 nM (IC50);MAP:19000 nM (IC50);PKC:14000 nM (IC50);EGFR:22000 nM (IC50);HIVProtease;CDK;Autophagy |
| 参考文献： |
1. Mahoney E, et al. ER stress and autophagy: new discoveries in the mechanism of action and drug resistance of the cyclin-dependent kinase inhibitor flavopiridol.Blood. 2012 Aug 9;120(6):1262-1273. 2. Keskin H, et al. Complex effects of flavopiridol on the expression of primary response genes. Cell Div. 2012 Mar 29;7:11. 3. Kim KS, et al.Thio- and oxoflavopiridols, cyclin-dependent kinase 1-selective inhibitors: synthesis and biological effects. J Med Chem. 2000 Nov 2;43(22):4126-34. |
| 溶解性： |
DMSO : ≥ 20 mg/mL (45.63 mM) H2O : ≥ 20 mg/mL (45.63 mM) DMF : 7.69 mg/mL (17.55 mM; Need ultrasonic) |
| 保存条件： |
-20℃ |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
2.282 ml |
11.408 ml |
22.815 ml |
| 5 mM |
0.456 ml |
2.282 ml |
4.563 ml |
| 10 mM |
0.228 ml |
1.141 ml |
2.282 ml |
| 50 mM |
0.046 ml |
0.228 ml |
0.456 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京