• 产品描述： Iloperidone (HP 873) is a D2/5-HT2 receptor antagonist. Iloperidone is an atypical antipsychotic for the schizophrenia symptoms

• 靶点： Rat D2 Receptor:54 nM (Ki);Rat 5-HT2 Receptor:3.1 nM (Ki);Rat D1 Receptor:546 nM (Ki);Rat 5-HT1A Receptor:168 nM (Ki);Rat 5-HT6 Receptor:42.7 μM (Ki);Rat 5-HT7 Receptor:21.6 nM (Ki);Human D1 Receptor:216 nM (Ki);Human D3 Receptor:7.1 nM (Ki);Human D4 Receptor:25 nM (Ki);Human D5 Receptor:319 nM (Ki);Human 5-HT2A Receptor:5.6 nM (Ki);Human 5-HT2C Receptor:42.8 nM (Ki);DopamineReceptor;5-HTReceptor;AdrenergicReceptor

• 体内研究：
  Iloperidone is eliminated slowly, with a mean t1/2 of 13.5 to 14.0 hours. Coadministration with food did not significantly affect AUC, tmax, or Cmax. These results indicate that the rate of iloperidone's absorption is decreased, but the overall bioavailability is unchanged, when the drug is taken with food. Orthostatic hypotension, dizziness, and somnolence were the most commonly reported adverse events

• 参考文献：
  1. Kongsamut, S., et al., Iloperidone binding to human and rat dopamine and 5-HT receptors. Eur J Pharmacol, 1996. 317(2-3): p. 417-23. 2. Sainati, S.M., et al., Safety, tolerability, and effect of food on the pharmacokinetics of iloperidone (HP 873), a potential atypical antipsychotic. J Clin Pharmacol, 1995. 35(7): p. 713-20. 3. Albers, L.J., A. Musenga, and M.A. Raggi, Iloperidone: a new benzisoxazole atypical antipsychotic drug. Is it novel enough to impact the crowded atypical antipsychotic market? Expert Opin Investig Drugs, 2008. 17(1): p. 61-75.

• 溶解性： Soluble  in  DMSO

• 保存条件： -20℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	2.345 ml	11.724 ml	23.448 ml
  5 mM	0.469 ml	2.345 ml	4.69 ml
  10 mM	0.234 ml	1.172 ml	2.345 ml
  50 mM	0.047 ml	0.234 ml	0.469 ml

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *