S80308 |
EPZ-5676 |
源叶(MedMol) | 99% |
- 提示:详情请下载说明书。
- 产品描述: Pinometostat (EPZ-5676) is a potent DOT1L histone methyltransferase inhibitor with a Ki of 80 pM.
- 靶点: Ki: < 80 pM (DOT1L histone methyltransferase);HistoneMethyltransferase
- 体内研究:
Pinometostat (EPZ-5676) (70 mg/kg, i.p.) causes complete and sustained regression in a rat xenograft model of MLL-rearranged leukemia. Pinometostat (EPZ-5676) (70, 35 mg/kg, i.v.) reduces HOXA9 and MEIS1 mRNA levels of tumors taken from rats, and reduces MLL-fusion target gene expression in vivo
- 参考文献:
1. Daigle SR, et al. Potent inhibition of DOT1L as treatment for MLL-fusion leukemia. Blood. 2013 Jun 25. [Epub ahead of print 2. Klaus CR, et al. DOT1L inhibitor EPZ-5676 displays synergistic antiproliferative activity in combination with standard of care drugs and hypomethylating agents in MLL-rearranged leukemia cells. J Pharmacol Exp Ther. 2014 Sep;350(3):646-56.
- 溶解性: DMSO : 100 mg/mL (177.71 mM; Need ultrasonic) Ethanol : 100 mg/mL (177.71 mM; Need ultrasonic)
- 保存条件: -20℃
- 配置溶液浓度参考:
1mg 5mg 10mg 1 mM 1.777 ml 8.886 ml 17.771 ml 5 mM 0.355 ml 1.777 ml 3.554 ml 10 mM 0.178 ml 0.889 ml 1.777 ml 50 mM 0.036 ml 0.178 ml 0.355 ml
- 注意:部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。
输入产品批号:
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)