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• 产品描述： Nexturastat A is a potent, selective HDAC6 inhibitor. Nexturastat A has inhibitory for HDAC6 with an IC50 of 5 nM. Nexturastat A can be used for the research of multiple myeloma (MM)

• 靶点： HDAC6:5.02 nM (IC50);HDAC8:0.954 μM (IC50);HDAC1:3.02 μM (IC50);HDAC7:4.46 μM (IC50);HDAC11:5.14 μM (IC50);HDAC3:6.68 μM (IC50);HDAC9:6.72 μM (IC50);HDAC2:6.92 μM (IC50);HDAC10:7.57 μM (IC50);HDAC4:9.39 μM (IC50);HDAC5:11.7 μM (IC50);HDAC

• 体内研究：
  Nexturastat A (NexA) (every two days, 20 days) inhibits tumor growth in murine xenograft models of MM

• 参考文献：
  1. Bergman JA, et al. Selective histone deacetylase 6 inhibitors bearing substituted urea linkers inhibit melanoma cell growth. J Med Chem. 2012 Nov 26;55(22):9891-9. 2. Xiaoyang Sun, et al. The selective HDAC6 inhibitor Nexturastat A induces apoptosis, overcomes drug resistance and inhibits tumor growth in multiple myeloma. Biosci Rep. 2019 Mar 22;39(3):BSR20181916.

• 溶解性： DMSO  :  ≥  56  mg/mL  (164.03  mM)

• 保存条件： RT

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	2.929 ml	14.646 ml	29.291 ml
  5 mM	0.586 ml	2.929 ml	5.858 ml
  10 mM	0.293 ml	1.465 ml	2.929 ml
  50 mM	0.059 ml	0.293 ml	0.586 ml

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *