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产品描述： Nexturastat A is a potent, selective HDAC6 inhibitor. Nexturastat A has inhibitory for HDAC6 with an IC50 of 5 nM. Nexturastat A can be used for the research of multiple myeloma (MM) |
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靶点：
HDAC6:5.02 nM (IC50);HDAC8:0.954 μM (IC50);HDAC1:3.02 μM (IC50);HDAC7:4.46 μM (IC50);HDAC11:5.14 μM (IC50);HDAC3:6.68 μM (IC50);HDAC9:6.72 μM (IC50);HDAC2:6.92 μM (IC50);HDAC10:7.57 μM (IC50);HDAC4:9.39 μM (IC50);HDAC5:11.7 μM (IC50);HDAC |
体内研究：
Nexturastat A (NexA) (every two days, 20 days) inhibits tumor growth in murine xenograft models of MM |
参考文献：
1. Bergman JA, et al. Selective histone deacetylase 6 inhibitors bearing substituted urea linkers inhibit melanoma cell growth. J Med Chem. 2012 Nov 26;55(22):9891-9. 2. Xiaoyang Sun, et al. The selective HDAC6 inhibitor Nexturastat A induces apoptosis, overcomes drug resistance and inhibits tumor growth in multiple myeloma. Biosci Rep. 2019 Mar 22;39(3):BSR20181916. |
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溶解性：
DMSO : ≥ 56 mg/mL (164.03 mM) |
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保存条件：
RT |
配置溶液浓度参考：
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1mg |
5mg |
10mg |
| 1 mM |
2.929 ml |
14.646 ml |
29.291 ml |
| 5 mM |
0.586 ml |
2.929 ml |
5.858 ml |
| 10 mM |
0.293 ml |
1.465 ml |
2.929 ml |
| 50 mM |
0.059 ml |
0.293 ml |
0.586 ml |
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| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
北京