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S80337

Exendin-4

源叶(MedMol) 98%
  • 英文名:
  • Exendin-4
  • 别名:
  • 艾塞那肽;HIS-GLY-GLU-GLY-THR-PHE-THR-SER-ASP-LEU-SER-LYS-GLN-MET-GLU-GLU-GLU-ALA-VAL-ARG-LEU-PHE-ILE-GLU-TRP-LEU-LYS-ASN-GLY-GLY-PRO-SER-;H-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-
  • CAS号:
  • 141758-74-9
  • 分子式:
  • C184H282N50O60S1
  • 分子量:
  • 4186.57
品牌货号产品规格价格(RMB) 库存(上海) 北京 武汉 南京 数量计量单位 加入购物车...
源叶(MedMol) S80337-1mg 98% ¥560.00元 >10 - - - EA 加入购物车
源叶(MedMol) S80337-5mg 98% ¥1280.00元 >10 - - - EA 加入购物车
源叶(MedMol) S80337-25mg 98% ¥2880.00元 >10 - - - EA 加入购物车
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  • 提示:详情请下载说明书。
  • 产品描述: Exendin-4 (Exenatide), a 39 amino acid peptide, is a long-acting glucagon-like peptide-1 receptor agonist with an IC50 of 3.22 nM.
  • 靶点: IC50: 3.22 nM (glucagon-like peptide-1 receptor);GlucagonReceptor
  • 体内研究:
    Both low- and high-dose exendin-4 treatment in ob/ob mice improve serum ALT and reduce serum glucose, and calculated HOMA scores compared with control. Exendin-4-treated ob/ob mice sustain a marked reduction in the net weight gain in the final 4 weeks of the study period. Animals treated with exendin-4 have more pancreatic acinar inflammation, more pyknotic nuclei and weigh significantly less than control rats. Exendin-4 treatment is associated with lower leptin levels as well as lower HOMA values in rats. Exenatide causes dose-dependent relaxation of rat thoracic aorta, which is evoked via the GLP-1 receptor and is mediated mainly by H2S but also by NO and CO.
  • 参考文献:
    1. Doyle ME, et al. The importance of the nine-amino acid C-terminal sequence of exendin-4 for binding to the GLP-1 receptor and for biological activity. Regul Pept. 2003 Jul 15;114(2-3):153-8. 2. Wei R, et al. Exenatide exerts direct protective effects on endothelial cells through the AMPK/Akt/eNOS pathway in a GLP-1 receptor-dependent manner. Am J Physiol Endocrinol Metab. 2016 Jun 1;310(11):E947-57. 3. Fidan-YaylalI G, et al. Antidiabetic exendin-4 activates apoptotic pathway and inhibits growth of breast cancer cells. Tumour Biol. 2016 Feb;37(2):2647-53. 4. Ding X, et al. Exendin-4, a glucagon-like protein-1 (GLP-1) receptor agonist, reverses hepatic steatosis in ob/obmice. Hepatology. 2006 Jan;43(1):173-81. 5. Nachnani JS, et al. Biochemical and histological effects of exendin-4 (exenatide) on the rat pancreas. Diabetologia. 2010 Jan;53(1):153-9. 6. Selley E, et al. Exenatide induces aortic vasodilation increasing hydrogen sulphide, carbon monoxide and nitric oxide production. Cardiovasc Diabetol. 2014 Apr 2;13:69.
  • 溶解性: H2O  :  33.33  mg/mL  (7.96  mM;  Need  ultrasonic)    DMSO  :  ≥  32  mg/mL  (7.64  mM)    Ethanol  :  <  1  mg/mL  (ultrasonic;warming;heat  to  60°C)  (insoluble)
  • 保存条件: -20℃
  • 配置溶液浓度参考:
    1mg 5mg 10mg
    1 mM 0.239 ml 1.194 ml 2.389 ml
    5 mM 0.048 ml 0.239 ml 0.478 ml
    10 mM 0.024 ml 0.119 ml 0.239 ml
    50 mM 0.005 ml 0.024 ml 0.048 ml
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