| 货号 | 规格 | 价格 | 上海 | 北京 | 武汉 | 南京 | 购买数量 |
|---|---|---|---|---|---|---|---|
S80338-2mg |
99.7% | ￥204.00 | 4 | - | - | - |
|
S80338-5mg |
99.7% | ￥306.00 | 8 | - | - | - |
|
S80338-10mg |
99.7% | ￥578.00 | 9 | - | - | - |
|
S80338-25mg |
99.7% | ￥952.00 | 8 | - | - | - |
|
S80338-50mg |
99.7% | ￥1768.00 | 3 | - | - | - |
|
S80338-100mg |
≥99% | ￥3060.00 | 货期：2-3天 | - | - | - |
|
NMS-873 is a potent, selective allosteric VCP/p97 inhibitor with an IC50 value of 30 nM.
| 产品描述： | NMS-873 is a potent, selective allosteric VCP/p97 inhibitor with an IC50 value of 30 nM. | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | IC50: 30 nM;p97 | ||||||||||||||||||||
| 体外研究： | NMS-873 has antiproliferative effect on a panel of tumor cell lines with IC50 values in the range of 0.08 μM to 2 μM. For HCT116 and HeLa cells, the IC50 values are 0.4 μM and 0.7 μM, respectively. NMS-873 reduces VCP sensitivity to trypsin digestion, preventing degradation of the linker-D2 domain. NMS-873 induces clear, dose-dependent accumulation of poly-Ub proteins and stabilization of cyclin E and Mcl-1 at doses consistent with its antiproliferative IC50 value | ||||||||||||||||||||
| 参考文献： | 1. Paola Magnaghi, et al. Covalent and allosteric inhibitors of the ATPATP ase VCP/p97 induce cancer cell death. Nat Chem Biol. 2013 Jul 28. doi: 10.1038/nchembio.1313. | ||||||||||||||||||||
| 溶解性： | soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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