| 产品描述： | NMS-873 is a potent, selective allosteric VCP/p97 inhibitor with an IC50 value of 30 nM. |
| 靶点： |
IC50: 30 nM;p97 |
| 体外研究： |
NMS-873 has antiproliferative effect on a panel of tumor cell lines with IC50 values in the range of 0.08 μM to 2 μM. For HCT116 and HeLa cells, the IC50 values are 0.4 μM and 0.7 μM, respectively. NMS-873 reduces VCP sensitivity to trypsin digestion, preventing degradation of the linker-D2 domain. NMS-873 induces clear, dose-dependent accumulation of poly-Ub proteins and stabilization of cyclin E and Mcl-1 at doses consistent with its antiproliferative IC50 value |
| 参考文献： |
1. Paola Magnaghi, et al. Covalent and allosteric inhibitors of the ATPATP ase VCP/p97 induce cancer cell death. Nat Chem Biol. 2013 Jul 28. doi: 10.1038/nchembio.1313. |
| 溶解性： |
soluble in DMSO |
| 保存条件： |
-20℃ |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
1.921 ml |
9.603 ml |
19.206 ml |
| 5 mM |
0.384 ml |
1.921 ml |
3.841 ml |
| 10 mM |
0.192 ml |
0.96 ml |
1.921 ml |
| 50 mM |
0.038 ml |
0.192 ml |
0.384 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京