| 货号 | 规格 | 价格 | 上海 | 北京 | 武汉 | 南京 | 购买数量 |
|---|---|---|---|---|---|---|---|
| S80345-5mg | 98% | ￥130.00 | 8 | - | - | - |
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| S80345-10mg | 98% | ￥200.00 | 9 | - | - | - |
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| S80345-25mg | 98% | ￥400.00 | 货期：2-3天 | - | - | - |
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| S80345-50mg | 98% | ￥700.00 | 7 | - | - | - |
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| S80345-100mg | 98% | ￥940.00 | 货期：2-3天 | - | - | - |
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Kenpaullone is a potent inhibitor of CDK1/cyclin B and GSK-3β, with IC50s of 0.4 μM and 23 nM, and also inhibits CDK2/cyclin A, CDK2/cyclin E, and CDK5/p25 with IC50s of 0.68 μM, 7.5 μM, 0.85 μM, respectively. Kenpaullone, a small molecule inhibitor of KLF4, reduces self-renewal of breast cancer stem cells and cell motility in vitro.
| 产品描述： | Kenpaullone is a potent inhibitor of CDK1/cyclin B and GSK-3β, with IC50s of 0.4 μM and 23 nM, and also inhibits CDK2/cyclin A, CDK2/cyclin E, and CDK5/p25 with IC50s of 0.68 μM, 7.5 μM, 0.85 μM, respectively. Kenpaullone, a small molecule inhibitor of KLF4, reduces self-renewal of breast cancer stem cells and cell motility in vitro. | ||||||||||||||||||||
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| 靶点： | Cdk1/cyclin B：0.4 μM (IC50)；cdk2/cyclin A：0.68 μM (IC50)；CDK5/p35：0.85 μM (IC50)；CDK2/cyclinE：7.5 μM (IC50)；GSK-3β：0.023 μM (IC50)；erk1：20 μM (IC50)；erk2：9 μM (IC50)；c-raf：38 μM (IC50);GSK-3;CDK | ||||||||||||||||||||
| 参考文献： | 1. Zaharevitz DW, et al. Discovery and initial characterization of the paullones, a novel class of small-molecule inhibitors of cyclin-dependent kinases. Cancer Res. 1999 Jun 1;59(11):2566-9. 2. Lyssiotis CA, et al. Reprogramming of murine fibroblasts to induced pluripotent stem cells with chemical complementation of Klf4. Proc Natl Acad Sci U S A. 2009 Jun 2;106(22):8912-7. 3. F Yu, et al. Kruppel-like factor 4 (KLF4) is required for maintenance of breast cancer stem cells and for cell migration and invasion. Oncogene. 2011 May 5;30(18):2161-72. | ||||||||||||||||||||
| 溶解性： | DMSO : ≥ 35 mg/mL (106.97 mM) | ||||||||||||||||||||
| 保存条件： | 2-8℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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