Kenpaullone

    
98%

8-Bromo-7,12-Dihydro-Indolo[3,2-D][1]-Benzazepin-6(5H)-One

源叶(MedMol)
S80345 一键复制产品信息
142273-20-9
C16H11BrN2O
327.18
肯帕罗酮;9-溴-7,12-二氢吲哚并[3,2-D][1]苯并氮杂卓-6(5H)-酮;9-Bromo-7,12-dihydro-indolo[3,2-d][1]benzazepin-6(5H)-one; 9-bromo-7,12-dihydro-5H-indolo[3,2-d][1]benzazepin-6-one;
货号 规格 价格 上海 北京 武汉 南京 购买数量
S80345-5mg 98% ¥130.00 8 - - -
S80345-10mg 98% ¥200.00 9 - - -
S80345-25mg 98% ¥400.00 货期:2-3天 - - -
S80345-50mg 98% ¥700.00 7 - - -
S80345-100mg 98% ¥940.00 货期:2-3天 - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品

产品介绍

Kenpaullone is a potent inhibitor of CDK1/cyclin B and GSK-3β, with IC50s of 0.4 μM and 23 nM, and also inhibits CDK2/cyclin A, CDK2/cyclin E, and CDK5/p25 with IC50s of 0.68 μM, 7.5 μM, 0.85 μM, respectively. Kenpaullone, a small molecule inhibitor of KLF4, reduces self-renewal of breast cancer stem cells and cell motility in vitro.

产品描述: Kenpaullone is a potent inhibitor of CDK1/cyclin B and GSK-3β, with IC50s of 0.4 μM and 23 nM, and also inhibits CDK2/cyclin A, CDK2/cyclin E, and CDK5/p25 with IC50s of 0.68 μM, 7.5 μM, 0.85 μM, respectively. Kenpaullone, a small molecule inhibitor of KLF4, reduces self-renewal of breast cancer stem cells and cell motility in vitro.
靶点: Cdk1/cyclin B:0.4 μM (IC50);cdk2/cyclin A:0.68 μM (IC50);CDK5/p35:0.85 μM (IC50);CDK2/cyclinE:7.5 μM (IC50);GSK-3β:0.023 μM (IC50);erk1:20 μM (IC50);erk2:9 μM (IC50);c-raf:38 μM (IC50);GSK-3;CDK
参考文献: 1. Zaharevitz DW, et al. Discovery and initial characterization of the paullones, a novel class of small-molecule inhibitors of cyclin-dependent kinases. Cancer Res. 1999 Jun 1;59(11):2566-9. 2. Lyssiotis CA, et al. Reprogramming of murine fibroblasts to induced pluripotent stem cells with chemical complementation of Klf4. Proc Natl Acad Sci U S A. 2009 Jun 2;106(22):8912-7. 3. F Yu, et al. Kruppel-like factor 4 (KLF4) is required for maintenance of breast cancer stem cells and for cell migration and invasion. Oncogene. 2011 May 5;30(18):2161-72.
溶解性: DMSO  :  ≥  35  mg/mL  (106.97  mM)
保存条件: 2-8℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 3.056 ml 15.282 ml 30.564 ml
5 mM 0.611 ml 3.056 ml 6.113 ml
10 mM 0.306 ml 1.528 ml 3.056 ml
50 mM 0.061 ml 0.306 ml 0.611 ml
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参考文献

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