体内研究: |
Cidofovir (5 mg/kg/day) subcutaneously for 5 days significantly reduces average virus infectivity titer in blood, spleen, lung and salivary gland in infected guinea pigs. Cidofovir significantly reduces lymphocytosis and average tissue indexe of spleen in infected animals. Cidofovir suppresses all manifestations (skin lesions, paralysis of the hind legs, and mortality) of hairless mice infected intracutaneously with HSV-1 or HSV-2. The most remarkable feature of Cidofovir is that a single administration of the compound, even as late as 4 days after infection, conferees significant protection against HSV-1 or HSV-2 infection. Cidofovir inhibits growth of the highly aggressive melanoma tumor arising from mouse melanoma B16 cells grafted subcutaneously in C57B16/J mice. |
参考文献: |
1.Redondo P, et al. Br J Dermatol, 2000, 143(4), 741-748. 2.Li SB, et al. Antiviral Res, 1990, 13(5), 237-252. 3.Snoeck R, et al, Antimicrob Agents Chemother, 1988, 32(12), 1839-1844. 4.Chatterjee S, et al. Antiviral Res., 1992, 19(3), 181-192. 5.De Clercq E, et al. Antimicrob Agents Chemother, 1991, 35(4), 701-706. |