• 产品描述： Cidofovir is an anti-CMV drug, It can suppress CMV replication by selective inhibition of viral DNA polymerase and therefore prevention of viral replication and transcription. idofovir is an injectable antiviral medication primarily used as a treatment for cytomegalovirus (CMV) retinitis- an infection of the retina of the eye in people with AIDS

• 体内研究：
  Cidofovir (5 mg/kg/day) subcutaneously for 5 days significantly reduces average virus infectivity titer in blood, spleen, lung and salivary gland in infected guinea pigs. Cidofovir significantly reduces lymphocytosis and average tissue indexe of spleen in infected animals. Cidofovir suppresses all manifestations (skin lesions, paralysis of the hind legs, and mortality) of hairless mice infected intracutaneously with HSV-1 or HSV-2. The most remarkable feature of Cidofovir is that a single administration of the compound, even as late as 4 days after infection, conferees significant protection against HSV-1 or HSV-2 infection. Cidofovir inhibits growth of the highly aggressive melanoma tumor arising from mouse melanoma B16 cells grafted subcutaneously in C57B16/J mice.

• 参考文献：
  1.Redondo P, et al. Br J Dermatol, 2000, 143(4), 741-748. 2.Li SB, et al. Antiviral Res, 1990, 13(5), 237-252. 3.Snoeck R, et al, Antimicrob Agents Chemother, 1988, 32(12), 1839-1844. 4.Chatterjee S, et al. Antiviral Res., 1992, 19(3), 181-192. 5.De Clercq E, et al. Antimicrob Agents Chemother, 1991, 35(4), 701-706.

• 溶解性： H2O:10  mM    DMSO:Insoluble

• 保存条件： 2-8℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	3.582 ml	17.909 ml	35.818 ml
  5 mM	0.716 ml	3.582 ml	7.164 ml
  10 mM	0.358 ml	1.791 ml	3.582 ml
  50 mM	0.072 ml	0.358 ml	0.716 ml

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *