Cidofovir

    
98%

Cidofovir

源叶(MedMol)
S80383 一键复制产品信息
149394-66-1
C8H14N3O6P
279.187
西多福韦二水合物;西多福韦 二水;Cidofovir hydrate (1:2);P-[[(1S)-2-(4-Amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)ethoxy]methyl]phosphonic acid hydrate (1:2);Cidofovir hydrate;Drg-0145;Gs-0504;Phosphonic acid, (
货号 规格 价格 上海 北京 武汉 南京 购买数量
S80383-10mg 98% ¥148.00 货期:2-3天 - - -
S80383-50mg 98% ¥290.00 1 - - -
S80383-100mg 98% ¥470.00 货期:2-3天 - - -
S80383-1g 98% ¥1955.00 货期:2-3天 - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品

产品介绍

Cidofovir is an anti-CMV drug, It can suppress CMV replication by selective inhibition of viral DNA polymerase and therefore prevention of viral replication and transcription. idofovir is an injectable antiviral medication primarily used as a treatment for cytomegalovirus (CMV) retinitis- an infection of the retina of the eye in people with AIDS

产品描述: Cidofovir is an anti-CMV drug, It can suppress CMV replication by selective inhibition of viral DNA polymerase and therefore prevention of viral replication and transcription. idofovir is an injectable antiviral medication primarily used as a treatment for cytomegalovirus (CMV) retinitis- an infection of the retina of the eye in people with AIDS
体内研究: Cidofovir (5 mg/kg/day) subcutaneously for 5 days significantly reduces average virus infectivity titer in blood, spleen, lung and salivary gland in infected guinea pigs. Cidofovir significantly reduces lymphocytosis and average tissue indexe of spleen in infected animals. Cidofovir suppresses all manifestations (skin lesions, paralysis of the hind legs, and mortality) of hairless mice infected intracutaneously with HSV-1 or HSV-2. The most remarkable feature of Cidofovir is that a single administration of the compound, even as late as 4 days after infection, conferees significant protection against HSV-1 or HSV-2 infection. Cidofovir inhibits growth of the highly aggressive melanoma tumor arising from mouse melanoma B16 cells grafted subcutaneously in C57B16/J mice.
参考文献: 1.Redondo P, et al. Br J Dermatol, 2000, 143(4), 741-748. 2.Li SB, et al. Antiviral Res, 1990, 13(5), 237-252. 3.Snoeck R, et al, Antimicrob Agents Chemother, 1988, 32(12), 1839-1844. 4.Chatterjee S, et al. Antiviral Res., 1992, 19(3), 181-192. 5.De Clercq E, et al. Antimicrob Agents Chemother, 1991, 35(4), 701-706.
溶解性: H2O:10  mM    DMSO:Insoluble
保存条件: 2-8℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 3.582 ml 17.909 ml 35.818 ml
5 mM 0.716 ml 3.582 ml 7.164 ml
10 mM 0.358 ml 1.791 ml 3.582 ml
50 mM 0.072 ml 0.358 ml 0.716 ml
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参考文献

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