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• 产品描述： BMS202 (PD-1/PD-L1 inhibitor 2)是一种抑制PD-1/PD-L1相互作用的小分子化合物，IC50为18 nM

• 靶点： PD-1/PD-L1 interaction(Cell-free assay):0.018 μM;Apoptosis;PD-1/PD-L1

• 体外研究：
  BMS-202 inhibits PD-1/PD-L1 binding in SCC-3 and Jurkat cells with IC50 of 15 μM and 10 μM, respectively.

• 体内研究：
  BMS-202 treatment shows a clear antitumor effect compared with the controls, in humanized MHC- dKO NOG mice.

• 细胞实验： Cell lines: SCC-3 and Jurkat cells Concentrations: IC50 of 15 μM and 10 μM Incubation Time: 4 days Method: Cells were treated with various concentrations of drug for 4 days.

• 动物实验： Animal Models: NOG-dKO mice Dosages: 20 mg/kg Administration: i.p.

• 参考文献：
  1. (WO2015034820), COMPOUNDS USEFUL AS IMMUNOMODULATORS. 2. Krzysztof M. Zak, et al. Structural basis for small molecule targeting of the programmed death ligand 1 (PD-L1). Oncotarget. 2016, 7(21): 30323–30335. 3. Ashizawa T, et al. Antitumor activity of the PD-1/PD-L1 binding inhibitor BMS-202 in the humanized MHC-double knockout NOG mouse. Biomed Res. 2019;40(6):243-250.

• 溶解性： Soluble  in  DMSO、Ethanol

• 保存条件： -20℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	2.384 ml	11.918 ml	23.837 ml
  5 mM	0.477 ml	2.384 ml	4.767 ml
  10 mM	0.238 ml	1.192 ml	2.384 ml
  50 mM	0.048 ml	0.238 ml	0.477 ml

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *