SB225002

    
99%

SB 225002

源叶(MedMol)
S80486 一键复制产品信息
182498-32-4
C13H10BrN3O4
352.14
N-(2-HYDROXY-4-NITROPHENYL)-N'-(2-BROMOPHENYL)UREA;N-(2-BROMOPHENYL)-N'-(2-HYDROXY-4-NITROPHENYL)UREA
货号 规格 价格 上海 北京 武汉 南京 购买数量
S80486-1mg 99% ¥190.00 8 - - -
S80486-5mg 99% ¥290.00 2 - - -
S80486-10mg 99% ¥408.00 4 - - -
S80486-25mg 99% ¥850.00 3 - - -
S80486-50mg 99% ¥1360.00 4 - - -
S80486-100mg 99% ¥2516.00 4 - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品

产品介绍

SB225002, a potent, selective and non-peptide CXCR2 antagonist, inhibits 125I-IL-8 binding to CXCR2 with an IC50 of 22 nM.

产品描述: SB225002, a potent, selective and non-peptide CXCR2 antagonist, inhibits 125I-IL-8 binding to CXCR2 with an IC50 of 22 nM.
靶点: 125I-IL-8-CXCR2:22 nM (IC50, in CHO cell membrane);CXCR
体内研究: SB225002 (SB 225002) selectively blocks IL-8-induced neutrophil margination in rabbits. CXCR2 is blocked using the selective antagonist SB225002 (2 mg/kg) or neutralizing CXCR2 antiserum. The CXCR2 antagonist SB225002 decreases neutrophil counts in ischemic hemispheres of ApoE−/− mice on Western diet and wildtype mice on normal diet. SB225002 significantly attenuates microglial activation and BBB damage, increases myelination, and reduces astrogliosis in the white matter after LPS-sensitized HI
参考文献: 1. White JR, et al. Identification of a potent, selective non-peptide CXCR2 antagonist that inhibits interleukin-8-induced neutrophil migration. J Biol Chem. 1998 Apr 24;273(17):10095-8. 2. Wang B, et al. A growth-related oncogene/CXC chemokine receptor 2 autocrine loop contributes to cellular proliferation in esophageal cancer. Cancer Res. 2006 Mar 15;66(6):3071-7. 3. Herz J, et al. Role of Neutrophils in Exacerbation of Brain Injury After Focal Cerebral Ischemia in Hyperlipidemic Mice. Stroke. 2015 Oct;46(10):2916-25. 4. Wang LY, et al. CXCL5 signaling is a shared pathway of neuroinflammation and blood-brain barrier injury contributing to white matter injury in the immature brain. J Neuroinflammation. 2016 Jan 6;13:6. 5. Shi ZR, et al. Decrease of galectin-3 in keratinocytes: A potential diagnostic marker and a critical contributor to the pathogenesis of psoriasis. J Autoimmun. 2018 May;89:30-40.
溶解性: DMSO  :  ≥  100  mg/mL  (283.98  mM)
保存条件: -20℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 2.84 ml 14.199 ml 28.398 ml
5 mM 0.568 ml 2.84 ml 5.68 ml
10 mM 0.284 ml 1.42 ml 2.84 ml
50 mM 0.057 ml 0.284 ml 0.568 ml
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参考文献

质检证书(COA)

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摩尔浓度计算器

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