| 产品描述： | PD168393 is a potent, selective and cell-permeable inhibitor of EGFR tyrosine kinase and ErbB2. PD168393 irreversiblely inactivates EGF receptor ( IC50=0.7 nM) and is inactive against insulin receptor, PDGFR, FGFR and PKC |
| 靶点： |
EGFR:0.7 nM (IC50);Apoptosis;EGFR;FGFR;IGF-1R;PDGFR;PKC;Autophagy |
| 体内研究： |
PD168393 (intraperitoneal injection; 58 mg/kg; once daily; days 10-14, 17-21, and 24-28) is effective in vivo, and produces tumor growth inhibition of 115% after 15 days’ treatment in human epidermoid carcinoma xenografts in mice |
| 参考文献： |
1. D W Fry, et al. Specific, irreversible inactivation of the epidermal growth factor receptor and erbB2, by a new class of tyrosine kinase inhibitor. Proc Natl Acad Sci U S A. 1998 Sep 29;95(20):12022-7. |
| 溶解性： |
DMSO : ≥ 30 mg/mL (81.25 mM) |
| 保存条件： |
RT |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
2.708 ml |
13.542 ml |
27.084 ml |
| 5 mM |
0.542 ml |
2.708 ml |
5.417 ml |
| 10 mM |
0.271 ml |
1.354 ml |
2.708 ml |
| 50 mM |
0.054 ml |
0.271 ml |
0.542 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京