货号	规格	价格	上海	北京	武汉	南京
S80534-1mg	98%	￥672.00 S80534-1mg ￥672.00 现货	2 2	-	-	-
S80534-5mg	98%	￥1520.00 S80534-5mg ￥1520.00 现货	4 4	-	-	-
S80534-25mg	98%	￥3840.00 S80534-25mg ￥3840.00 2-3天	0 货期：2-3天	-	-	-

产品介绍

Z-IETD-FMK (Caspase-8 Inhibitor, Z-IE(OMe)TD(OMe)-FMK)是一种特异性Caspase-8抑制剂。Z-IETD-FMK也是颗粒酶B（granzyme B）抑制剂

产品描述：

Z-IETD-FMK (Caspase-8 Inhibitor, Z-IE(OMe)TD(OMe)-FMK)是一种特异性Caspase-8抑制剂。Z-IETD-FMK也是颗粒酶B（granzyme B）抑制剂

靶点：

Caspase-8;Caspase

体外研究：

Z-IETD-FMK, which inhibits the cleavage of caspase-8 and partially inhibits the cleavage of caspase-3 and PARP, prevents the execution of apoptosis in retinal cells exposed to different apoptotic stimuli. Z-IETD-FMK (50 μM) reduces ceramide-induced cardiomyocyte death and significantly inhibits the activation of caspase 3. Inhibition of caspase-8 by Z-IETD-FMK affects the generation of activated/memory T cells and T cell cytokine production, and decreases NF-kappaB responses to TCR:CD3 engagement in T cell cultures.

体内研究：

In vivo, inhibition of caspase-8 by Z-IETD-FMK reduces memory/activated CD4 and CD8 T cells, and increases susceptibility to T. cruzi infection. Z-IETD-FMK promotes neuronal survival and regeneration of injured retinal ganglion cells after CNS injuries.

细胞实验：

Cell lines: Rat neonatal cardiomyocytes Concentrations: 50 µM Incubation Time: 24 h Method: Drugs were added to the cell culture medium simultaneously with ceramide, and surviving cells were counted 24 hours later.

动物实验：

Animal Models: T. cruzi-infected mice Dosages: 0.4 mg/3 days Administration: --

参考文献：

1. Tezel G, et al. Inhibition of caspase activity in retinal cell apoptosis induced by various stimuli in vitro. Invest Ophthalmol Vis Sci. 1999, 40(11), 2660-2667. 2. Wang J, et al. Involvement of caspase 3- and 8-like proteases in ceramide-induced apoptosis of cardiomyocytes. J Card Fail. 2000, 6(3), 243-249. 3. Silva EM, et al. Caspase-8 activity prevents type 2 cytokine responses and is required for protective T cell-mediated immunity against Trypanosoma cruzi infection. J Immunol. 2005, 174(10), 6314-6321. 4. Monnier PP, et al. Involvement of caspase-6 and caspase-8 in neuronal apoptosis and the regenerative failure of injured retinal ganglion cells. J Neurosci. 2011, 31(29), 10494-10505.

溶解性：

soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.527 ml	7.637 ml	15.275 ml
5 mM	0.305 ml	1.527 ml	3.055 ml
10 mM	0.153 ml	0.764 ml	1.527 ml
50 mM	0.031 ml	0.153 ml	0.305 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

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体积

分子摩尔量

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Z-IETD-FMK