| 产品描述： | SU5402 is a potent multi-targeted receptor tyrosine kinase inhibitor with IC50 of 20 nM, 30 nM, and 510 nM for VEGFR2, FGFR1, and PDGF-Rβ, respectively. |
| 靶点： |
FGFR;PDGFR;VEGFR;VEGFR;FGFR;PDGFR |
| 体内研究： |
In mice, SU5416 (25 mg/kg, i.p.) inhibits subcutaneous growth of a panel of tumor cell lines by inhibiting the angiogenic process associated with tumor growth. |
| 细胞实验： |
Tumor cell lines used in the in vitro growth are cultured in media at 37°C in 5–10% CO2. SU5416 is serially diluted in media containing DMSO (<0.5%) and added to cultures of tumor cells 1 day after the initiation of culture. Cell growth is measured after 96 h using the sulforhodamine B method. IC50s are calculated by curve fitting using four-parameter analysis.(Only for Reference) |
| 参考文献： |
1.Li Y, et al. Calcif Tissue Int. 2013, 93(6), 556-5 64. 2.Sun L, et al. J Med Chem. 1999, 42(25), 5120-5130. 3.Lo AK, et al. J Pathol. 2015. doi: 10.12002/path.4575. 4.Fong TA, et al. Cancer Res. 1999, 59(1), 99-106. 5.Trzcińska-Daneluti AM, et al. RNA Interference Screen to Identify Kinases That Suppress Rescue of ΔF508-CFTR. Mol Cell Proteomics. 2015 Jun;14(6):1569-83. |
| 溶解性： |
DMSO:29.6 mg/mL (100 mM) |
| 保存条件： |
2-8℃ |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
3.375 ml |
16.874 ml |
33.747 ml |
| 5 mM |
0.675 ml |
3.375 ml |
6.749 ml |
| 10 mM |
0.337 ml |
1.687 ml |
3.375 ml |
| 50 mM |
0.067 ml |
0.337 ml |
0.675 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京