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• 产品描述： BTB06584 is a selective and IF1-dependent mitochondrial F1Fo-ATPase inhibitor without compromising ATP synthesis. BTB06584 can delays ischaemic cell death

• 靶点： Mitochondrial F1Fo-ATPase;RAAS;ATPase

• 体外研究：
  In HL-1 cells, BTB06584 (100 μM) inhibits F1Fo-ATPase activity with no effect on the mitochondrial membrane potential (ΔΨm ) or O2 consumption. BTB06584 (100 μM) pretreatmet protects against ischaemic cell death in HL-1 cells prior to a period of ischaemia. ATP consumption is decreased following inhibition of respiration, and ischaemic cell death is reduced. BTB06584 efficiency is increased by IF1 overexpression and reduced by silencing the protein

• 体内研究：
  BTB06584 (1 μM; 24 hours) treatment rescued defective haemoglobin synthesis in zebrafish pinotage (pnt) mutants in which expression of the Atpif1a gene is lost. The concentrations of BTB06584 that restore haemoglobin biosynthesis also alter mitochondrial bioenergetics in living fish

• 参考文献：
  1. Ivanes F, et al. The compound BTB06584 is an IF1 -dependent selective inhibitor of the mitochondrial F1 Fo-ATPase. Br J Pharmacol. 2014 Sep;171(18):4193-4206.

• 溶解性： soluble  in  DMSO

• 保存条件： -20℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	2.393 ml	11.967 ml	23.934 ml
  5 mM	0.479 ml	2.393 ml	4.787 ml
  10 mM	0.239 ml	1.197 ml	2.393 ml
  50 mM	0.048 ml	0.239 ml	0.479 ml

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *