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产品描述： Selamectin, a semi-synthetic macrocyclic lactone, is a potent parasiticide and anthelminthic. Selamectin activates glutamate-gated chloride channels in neurons and pharyngeal muscles to prevent heartworm, Lymphatic filariae, and nematode infection. Selamectin is also a potent P-glycoprotein substrate and a P-glycoprotein inhibitor with an IC50 of 120 nM |
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靶点：
Parasite;Chloride Channel;P-glycoprotein;Bacterial;Chloridechannel;P-gp;Parasite |
体内研究：
A single administration of 6 mg/kg topical Selamectin given every two months could effectively prevent B. malayi infection in cats. Application of topical Selamectin twice a year could block circulating microfilariae |
参考文献：
1. Patsharaporn T Sarasombath, et al. First study of topical selamectin efficacy for treating cats naturally infected with Brugia malayi and Brugia pahangi under field conditions. Parasitol Res. 2019 Apr;118(4):1289-1297. 2. J Griffin, et al. Selamectin is a potent substrate and inhibitor of human and canine P-glycoprotein. J Vet Pharmacol Ther. 2005 Jun;28(3):257-65. |
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溶解性：
DMSO : ≥ 100 mg/mL (129.88 mM) |
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保存条件：
-20℃ |
配置溶液浓度参考：
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1mg |
5mg |
10mg |
| 1 mM |
1.299 ml |
6.494 ml |
12.988 ml |
| 5 mM |
0.26 ml |
1.299 ml |
2.598 ml |
| 10 mM |
0.13 ml |
0.649 ml |
1.299 ml |
| 50 mM |
0.026 ml |
0.13 ml |
0.26 ml |
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| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
北京