| 货号 | 规格 | 价格 | 上海 | 北京 | 武汉 | 南京 | 购买数量 |
|---|---|---|---|---|---|---|---|
S80615-2mg |
99.9% | ￥288.00 | 7 | - | - | - |
|
S80615-5mg |
99.9% | ￥360.00 | 8 | - | - | - |
|
S80615-10mg |
99.9% | ￥450.00 | 7 | - | - | - |
|
S80615-50mg |
99.9% | ￥1200.00 | 7 | - | - | - |
|
S80615-100mg |
99.9% | ￥1900.00 | 4 | - | - | - |
|
CFTR(inh)-172 is a potent and selective blocker of the CFTR chloride channel; reversibly inhibits CFTR short-circuit current in less than 2 minutes with a Ki of 300 nM.
| 产品描述： | CFTR(inh)-172 is a potent and selective blocker of the CFTR chloride channel; reversibly inhibits CFTR short-circuit current in less than 2 minutes with a Ki of 300 nM. | ||||||||||||||||||||
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| 靶点： | Ki: 300 nM (CFTR);CFTR;Autophagy | ||||||||||||||||||||
| 体内研究： | A single intraperitoneal injection of CFTR(inh)-172 (250 μg/kg) in mice reduces by more than 90% cholera toxin–induced fluid secretion in the small intestine over 6 hours. CFTR(inh)-172 is nontoxic at high concentrations in mouse models. CFTRinh-172 significantly reduces fluid secretion to that in saline control loops, whereas an inactive CFTRinh-172 analog does not inhibit fluid secretion | ||||||||||||||||||||
| 参考文献： | 1. Ma T, et al. Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin-induced intestinal fluid secretion. J Clin Invest. 2002 Dec;110(11):1651-8. 2. Taddei A, et al. Altered channel gating mechanism for CFTR inhibition by a high-affinity thiazolidinone blocker. FEBS Lett. 2004 Jan 30;558(1-3):52-6. | ||||||||||||||||||||
| 溶解性： | DMSO : 50 mg/mL (122.13 mM; Need ultrasonic) | ||||||||||||||||||||
| 保存条件： | 2-8℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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